BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

258 related articles for article (PubMed ID: 18937395)

  • 1. Design of small-molecule peptidic and nonpeptidic Smac mimetics.
    Sun H; Nikolovska-Coleska Z; Yang CY; Qian D; Lu J; Qiu S; Bai L; Peng Y; Cai Q; Wang S
    Acc Chem Res; 2008 Oct; 41(10):1264-77. PubMed ID: 18937395
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bivalent SMAC Mimetics for Treating Cancer by Antagonizing Inhibitor of Apoptosis Proteins.
    Zhu H; Li Y; Liu Y; Han B
    ChemMedChem; 2019 Dec; 14(23):1951-1962. PubMed ID: 31692274
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design of small-molecule Smac mimetics as IAP antagonists.
    Wang S
    Curr Top Microbiol Immunol; 2011; 348():89-113. PubMed ID: 21072626
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
    Sun H; Nikolovska-Coleska Z; Lu J; Meagher JL; Yang CY; Qiu S; Tomita Y; Ueda Y; Jiang S; Krajewski K; Roller PP; Stuckey JA; Wang S
    J Am Chem Soc; 2007 Dec; 129(49):15279-94. PubMed ID: 17999504
    [TBL] [Abstract][Full Text] [Related]  

  • 5. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.
    Lu J; Bai L; Sun H; Nikolovska-Coleska Z; McEachern D; Qiu S; Miller RS; Yi H; Shangary S; Sun Y; Meagher JL; Stuckey JA; Wang S
    Cancer Res; 2008 Nov; 68(22):9384-93. PubMed ID: 19010913
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
    Corti A; Milani M; Lecis D; Seneci P; de Rosa M; Mastrangelo E; Cossu F
    FEBS J; 2018 Sep; 285(17):3286-3298. PubMed ID: 30055105
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.
    Sun H; Liu L; Lu J; Bai L; Li X; Nikolovska-Coleska Z; McEachern D; Yang CY; Qiu S; Yi H; Sun D; Wang S
    J Med Chem; 2011 May; 54(9):3306-18. PubMed ID: 21462933
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.
    Benetatos CA; Mitsuuchi Y; Burns JM; Neiman EM; Condon SM; Yu G; Seipel ME; Kapoor GS; Laporte MG; Rippin SR; Deng Y; Hendi MS; Tirunahari PK; Lee YH; Haimowitz T; Alexander MD; Graham MA; Weng D; Shi Y; McKinlay MA; Chunduru SK
    Mol Cancer Ther; 2014 Apr; 13(4):867-79. PubMed ID: 24563541
    [TBL] [Abstract][Full Text] [Related]  

  • 9. IAP Proteins Antagonist: An Introduction and Chemistry of Smac Mimetics under Clinical Development.
    Ali R; Singh S; Haq W
    Curr Med Chem; 2018; 25(31):3768-3795. PubMed ID: 29532750
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression.
    Petersen SL; Peyton M; Minna JD; Wang X
    Proc Natl Acad Sci U S A; 2010 Jun; 107(26):11936-41. PubMed ID: 20547836
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
    Welsh K; Milutinovic S; Ardecky RJ; Gonzalez-Lopez M; Ganji SR; Teriete P; Finlay D; Riedl S; Matsuzawa S; Pinilla C; Houghten R; Vuori K; Reed JC; Cosford ND
    PLoS One; 2016; 11(9):e0161952. PubMed ID: 27617834
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design of potent, conformationally constrained Smac mimetics.
    Sun H; Nikolovska-Coleska Z; Yang CY; Xu L; Liu M; Tomita Y; Pan H; Yoshioka Y; Krajewski K; Roller PP; Wang S
    J Am Chem Soc; 2004 Dec; 126(51):16686-7. PubMed ID: 15612682
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.
    Dai Y; Liu M; Tang W; Li Y; Lian J; Lawrence TS; Xu L
    BMC Cancer; 2009 Nov; 9():392. PubMed ID: 19895686
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
    Allensworth JL; Sauer SJ; Lyerly HK; Morse MA; Devi GR
    Breast Cancer Res Treat; 2013 Jan; 137(2):359-71. PubMed ID: 23225169
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP).
    Sun H; Stuckey JA; Nikolovska-Coleska Z; Qin D; Meagher JL; Qiu S; Lu J; Yang CY; Saito NG; Wang S
    J Med Chem; 2008 Nov; 51(22):7169-80. PubMed ID: 18954041
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.
    Bockbrader KM; Tan M; Sun Y
    Oncogene; 2005 Nov; 24(49):7381-8. PubMed ID: 16044155
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.
    Cossu F; Mastrangelo E; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Seneci P; Scolastico C; Bolognesi M
    Biochem Biophys Res Commun; 2009 Jan; 378(2):162-7. PubMed ID: 18992220
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
    Zobel K; Wang L; Varfolomeev E; Franklin MC; Elliott LO; Wallweber HJ; Okawa DC; Flygare JA; Vucic D; Fairbrother WJ; Deshayes K
    ACS Chem Biol; 2006 Sep; 1(8):525-33. PubMed ID: 17168540
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis.
    Yang C; Ran Q; Zhou Y; Liu S; Zhao C; Yu X; Zhu F; Ji Y; Du Q; Yang T; Zhang W; He S
    Apoptosis; 2020 Jun; 25(5-6):441-455. PubMed ID: 32418059
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Small molecule inhibitor of apoptosis proteins antagonists: a patent review.
    Hird AW; Aquila BM; Hennessy EJ; Vasbinder MM; Yang B
    Expert Opin Ther Pat; 2015 Jul; 25(7):755-74. PubMed ID: 25980951
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.