These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 18948269)

  • 1. RalA functions as an indispensable signal mediator for the nutrient-sensing system.
    Maehama T; Tanaka M; Nishina H; Murakami M; Kanaho Y; Hanada K
    J Biol Chem; 2008 Dec; 283(50):35053-9. PubMed ID: 18948269
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
    Sato T; Nakashima A; Guo L; Tamanoi F
    J Biol Chem; 2009 May; 284(19):12783-91. PubMed ID: 19299511
    [TBL] [Abstract][Full Text] [Related]  

  • 3. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
    Oshiro N; Takahashi R; Yoshino K; Tanimura K; Nakashima A; Eguchi S; Miyamoto T; Hara K; Takehana K; Avruch J; Kikkawa U; Yonezawa K
    J Biol Chem; 2007 Jul; 282(28):20329-39. PubMed ID: 17517883
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
    Sato T; Umetsu A; Tamanoi F
    Methods Enzymol; 2008; 438():307-20. PubMed ID: 18413257
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Alkaline intracellular pH (pHi) increases PI3K activity to promote mTORC1 and mTORC2 signaling and function during growth factor limitation.
    Kazyken D; Lentz SI; Wadley M; Fingar DC
    J Biol Chem; 2023 Sep; 299(9):105097. PubMed ID: 37507012
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.
    Smith EM; Finn SG; Tee AR; Browne GJ; Proud CG
    J Biol Chem; 2005 May; 280(19):18717-27. PubMed ID: 15772076
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
    Tamai T; Yamaguchi O; Hikoso S; Takeda T; Taneike M; Oka T; Oyabu J; Murakawa T; Nakayama H; Uno Y; Horie K; Nishida K; Sonenberg N; Shah AM; Takeda J; Komuro I; Otsu K
    J Biol Chem; 2013 Apr; 288(14):10176-10187. PubMed ID: 23426372
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.
    Wu D; Chapman JR; Wang L; Harris TE; Shabanowitz J; Hunt DF; Fu Z
    J Biol Chem; 2012 Apr; 287(15):12510-9. PubMed ID: 22356909
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1).
    Xu L; Salloum D; Medlin PS; Saqcena M; Yellen P; Perrella B; Foster DA
    J Biol Chem; 2011 Jul; 286(29):25477-86. PubMed ID: 21622984
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.
    Wang X; Fonseca BD; Tang H; Liu R; Elia A; Clemens MJ; Bommer UA; Proud CG
    J Biol Chem; 2008 Nov; 283(45):30482-92. PubMed ID: 18676370
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The late endosome is essential for mTORC1 signaling.
    Flinn RJ; Yan Y; Goswami S; Parker PJ; Backer JM
    Mol Biol Cell; 2010 Mar; 21(5):833-41. PubMed ID: 20053679
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.
    Fonseca BD; Smith EM; Lee VH; MacKintosh C; Proud CG
    J Biol Chem; 2007 Aug; 282(34):24514-24. PubMed ID: 17604271
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
    Karassek S; Berghaus C; Schwarten M; Goemans CG; Ohse N; Kock G; Jockers K; Neumann S; Gottfried S; Herrmann C; Heumann R; Stoll R
    J Biol Chem; 2010 Oct; 285(44):33979-91. PubMed ID: 20685651
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tumorigenic activity and therapeutic inhibition of Rheb GTPase.
    Mavrakis KJ; Zhu H; Silva RL; Mills JR; Teruya-Feldstein J; Lowe SW; Tam W; Pelletier J; Wendel HG
    Genes Dev; 2008 Aug; 22(16):2178-88. PubMed ID: 18708578
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
    Garami A; Zwartkruis FJ; Nobukuni T; Joaquin M; Roccio M; Stocker H; Kozma SC; Hafen E; Bos JL; Thomas G
    Mol Cell; 2003 Jun; 11(6):1457-66. PubMed ID: 12820960
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.
    Wagner RJ; Martin KA; Powell RJ; Rzucidlo EM
    Am J Physiol Cell Physiol; 2010 Jul; 299(1):C119-27. PubMed ID: 20375271
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.
    Yu J; Henske EP
    Cancer Res; 2006 Oct; 66(19):9461-6. PubMed ID: 17018601
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
    Sancak Y; Bar-Peled L; Zoncu R; Markhard AL; Nada S; Sabatini DM
    Cell; 2010 Apr; 141(2):290-303. PubMed ID: 20381137
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.
    Lee MN; Ha SH; Kim J; Koh A; Lee CS; Kim JH; Jeon H; Kim DH; Suh PG; Ryu SH
    Mol Cell Biol; 2009 Jul; 29(14):3991-4001. PubMed ID: 19451232
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.