BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 18949455)

  • 1. Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells.
    Farrelly AM; Wobser H; Bonner C; Anguissola S; Rehm M; Concannon CG; Prehn JH; Byrne MM
    Diabetologia; 2009 Jan; 52(1):136-44. PubMed ID: 18949455
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells.
    Farrelly AM; Kilbride SM; Bonner C; Prehn JH; Byrne MM
    Apoptosis; 2011 Nov; 16(11):1128-37. PubMed ID: 21874357
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function.
    Wobser H; Bonner C; Nolan JJ; Byrne MM; Prehn JH
    Diabetologia; 2006 Mar; 49(3):519-26. PubMed ID: 16440211
    [TBL] [Abstract][Full Text] [Related]  

  • 4. INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.
    Bonner C; Bacon S; Concannon CG; Rizvi SR; Baquié M; Farrelly AM; Kilbride SM; Dussmann H; Ward MW; Boulanger CM; Wollheim CB; Graf R; Byrne MM; Prehn JH
    Diabetes; 2010 Nov; 59(11):2799-808. PubMed ID: 20682686
    [TBL] [Abstract][Full Text] [Related]  

  • 5. AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
    Kilbride SM; Farrelly AM; Bonner C; Ward MW; Nyhan KC; Concannon CG; Wollheim CB; Byrne MM; Prehn JH
    J Biol Chem; 2010 Nov; 285(46):36199-206. PubMed ID: 20841353
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.
    Wobser H; Düssmann H; Kögel D; Wang H; Reimertz C; Wollheim CB; Byrne MM; Prehn JH
    J Biol Chem; 2002 Feb; 277(8):6413-21. PubMed ID: 11724785
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.
    Bonner C; Farrelly AM; Concannon CG; Dussmann H; Baquié M; Virard I; Wobser H; Kögel D; Wollheim CB; Rupnik M; Byrne MM; König HG; Prehn JH
    J Biol Chem; 2011 Jul; 286(29):25719-28. PubMed ID: 21628466
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion.
    Chen L; Xu B; Liu L; Liu C; Luo Y; Chen X; Barzegar M; Chung J; Huang S
    Oncotarget; 2015 Mar; 6(9):7136-50. PubMed ID: 25762619
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Increased milk protein synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of rapamycin (mTOR)C1-dependent and independent cell signaling.
    Sciascia Q; Pacheco D; McCoard SA
    J Dairy Sci; 2013 Apr; 96(4):2327-2338. PubMed ID: 23462168
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young.
    Kyithar MP; Bonner C; Bacon S; Kilbride SM; Schmid J; Graf R; Prehn JH; Byrne MM
    J Transl Med; 2013 Jun; 11():156. PubMed ID: 23803251
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.
    Ellard S; Colclough K
    Hum Mutat; 2006 Sep; 27(9):854-69. PubMed ID: 16917892
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated.
    Suryawan A; Orellana RA; Nguyen HV; Jeyapalan AS; Fleming JR; Davis TA
    Am J Physiol Endocrinol Metab; 2007 Dec; 293(6):E1597-605. PubMed ID: 17878222
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer.
    Luo Z; Li Y; Wang H; Fleming J; Li M; Kang Y; Zhang R; Li D
    PLoS One; 2015; 10(3):e0121082. PubMed ID: 25793983
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.
    Jhanwar-Uniyal M; Gillick JL; Neil J; Tobias M; Thwing ZE; Murali R
    Adv Biol Regul; 2015 Jan; 57():64-74. PubMed ID: 25442674
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis.
    Pelletier L; Rebouissou S; Paris A; Rathahao-Paris E; Perdu E; Bioulac-Sage P; Imbeaud S; Zucman-Rossi J
    Hepatology; 2010 Feb; 51(2):557-66. PubMed ID: 20041408
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
    Ahmed M; Hussain AR; Bavi P; Ahmed SO; Al Sobhi SS; Al-Dayel F; Uddin S; Al-Kuraya KS
    Carcinogenesis; 2014 Jul; 35(7):1564-72. PubMed ID: 24583924
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of circulating microRNAs in HNF1A-MODY carriers.
    Bonner C; Nyhan KC; Bacon S; Kyithar MP; Schmid J; Concannon CG; Bray IM; Stallings RL; Prehn JH; Byrne MM
    Diabetologia; 2013 Aug; 56(8):1743-51. PubMed ID: 23674172
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.
    Hayashi AA; Proud CG
    Am J Physiol Endocrinol Metab; 2007 Jun; 292(6):E1647-55. PubMed ID: 17284572
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Natural killer group 2D and CD28 receptors differentially activate mammalian/mechanistic target of rapamycin to alter murine effector CD8+ T-cell differentiation.
    McQueen B; Trace K; Whitman E; Bedsworth T; Barber A
    Immunology; 2016 Mar; 147(3):305-20. PubMed ID: 26661515
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.
    Korkolopoulou P; Levidou G; Trigka EA; Prekete N; Karlou M; Thymara I; Sakellariou S; Fragkou P; Isaiadis D; Pavlopoulos P; Patsouris E; Saetta AA
    BJU Int; 2012 Dec; 110(11 Pt C):E1237-48. PubMed ID: 23107319
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.