These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 18951788)

  • 1. Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
    Walker DP; Bi FC; Kalgutkar AS; Bauman JN; Zhao SX; Soglia JR; Aspnes GE; Kung DW; Klug-McLeod J; Zawistoski MP; McGlynn MA; Oliver R; Dunn M; Li JC; Richter DT; Cooper BA; Kath JC; Hulford CA; Autry CL; Luzzio MJ; Ung EJ; Roberts WG; Bonnette PC; Buckbinder L; Mistry A; Griffor MC; Han S; Guzman-Perez A
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6071-7. PubMed ID: 18951788
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.
    Allen JG; Lee MR; Han CY; Scherrer J; Flynn S; Boucher C; Zhao H; O'Connor AB; Roveto P; Bauer D; Graceffa R; Richards WG; Babij P
    Bioorg Med Chem Lett; 2009 Sep; 19(17):4924-8. PubMed ID: 19648005
    [TBL] [Abstract][Full Text] [Related]  

  • 3. N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
    Deak HL; Newcomb JR; Nunes JJ; Boucher C; Cheng AC; DiMauro EF; Epstein LF; Gallant P; Hodous BL; Huang X; Lee JH; Patel VF; Schneider S; Turci SM; Zhu X
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1172-6. PubMed ID: 18083554
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and structure based optimization of novel Akt inhibitors.
    Lippa B; Pan G; Corbett M; Li C; Kauffman GS; Pandit J; Robinson S; Wei L; Kozina E; Marr ES; Borzillo G; Knauth E; Barbacci-Tobin EG; Vincent P; Troutman M; Baker D; Rajamohan F; Kakar S; Clark T; Morris J
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3359-63. PubMed ID: 18456494
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.
    Choi HS; Wang Z; Richmond W; He X; Yang K; Jiang T; Karanewsky D; Gu XJ; Zhou V; Liu Y; Che J; Lee CC; Caldwell J; Kanazawa T; Umemura I; Matsuura N; Ohmori O; Honda T; Gray N; He Y
    Bioorg Med Chem Lett; 2006 May; 16(10):2689-92. PubMed ID: 16524731
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.
    Tse KW; Lin KB; Dang-Lawson M; Guzman-Perez A; Aspnes GE; Buckbinder L; Gold MR
    Cell Immunol; 2012; 275(1-2):47-54. PubMed ID: 22507871
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.
    Choi HS; Wang Z; Richmond W; He X; Yang K; Jiang T; Sim T; Karanewsky D; Gu XJ; Zhou V; Liu Y; Ohmori O; Caldwell J; Gray N; He Y
    Bioorg Med Chem Lett; 2006 Apr; 16(8):2173-6. PubMed ID: 16458503
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
    Walker DP; Zawistoski MP; McGlynn MA; Li JC; Kung DW; Bonnette PC; Baumann A; Buckbinder L; Houser JA; Boer J; Mistry A; Han S; Xing L; Guzman-Perez A
    Bioorg Med Chem Lett; 2009 Jun; 19(12):3253-8. PubMed ID: 19428251
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
    DiMauro EF; Newcomb J; Nunes JJ; Bemis JE; Boucher C; Chai L; Chaffee SC; Deak HL; Epstein LF; Faust T; Gallant P; Gore A; Gu Y; Henkle B; Hsieh F; Huang X; Kim JL; Lee JH; Martin MW; McGowan DC; Metz D; Mohn D; Morgenstern KA; Oliveira-dos-Santos A; Patel VF; Powers D; Rose PE; Schneider S; Tomlinson SA; Tudor YY; Turci SM; Welcher AA; Zhao H; Zhu L; Zhu X
    J Med Chem; 2008 Mar; 51(6):1681-94. PubMed ID: 18321037
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
    Bhattacharya SK; Aspnes GE; Bagley SW; Boehm M; Brosius AD; Buckbinder L; Chang JS; Dibrino J; Eng H; Frederick KS; Griffith DA; Griffor MC; GuimarĂ£es CR; Guzman-Perez A; Han S; Kalgutkar AS; Klug-McLeod J; Garcia-Irizarry C; Li J; Lippa B; Price DA; Southers JA; Walker DP; Wei L; Xiao J; Zawistoski MP; Zhao X
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7523-9. PubMed ID: 23153798
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
    Liu M; Wang S; Clampit JE; Gum RJ; Haasch DL; Rondinone CM; Trevillyan JM; Abad-Zapatero C; Fry EH; Sham HL; Liu G
    Bioorg Med Chem Lett; 2007 Feb; 17(3):668-72. PubMed ID: 17107797
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Focal adhesion kinase: exploring Fak structure to gain insight into function.
    Hall JE; Fu W; Schaller MD
    Int Rev Cell Mol Biol; 2011; 288():185-225. PubMed ID: 21482413
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.
    Holsworth DD; Jalaie M; Belliotti T; Cai C; Collard W; Ferreira S; Powell NA; Stier M; Zhang E; McConnell P; Mochalkin I; Ryan MJ; Bryant J; Li T; Kasani A; Subedi R; Maiti SN; Edmunds JJ
    Bioorg Med Chem Lett; 2007 Jul; 17(13):3575-80. PubMed ID: 17482464
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.
    Luke RW; Ballard P; Buttar D; Campbell L; Curwen J; Emery SC; Griffen AM; Hassall L; Hayter BR; Jones CD; McCoull W; Mellor M; Swain ML; Tucker JA
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6670-4. PubMed ID: 19854647
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.
    Wyss PC; Gerber P; Hartman PG; Hubschwerlen C; Locher H; Marty HP; Stahl M
    J Med Chem; 2003 Jun; 46(12):2304-12. PubMed ID: 12773035
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
    Richardson CM; Williamson DS; Parratt MJ; Borgognoni J; Cansfield AD; Dokurno P; Francis GL; Howes R; Moore JD; Murray JB; Robertson A; Surgenor AE; Torrance CJ
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1353-7. PubMed ID: 16325401
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
    Das J; Moquin RV; Pitt S; Zhang R; Shen DR; McIntyre KW; Gillooly K; Doweyko AM; Sack JS; Zhang H; Kiefer SE; Kish K; McKinnon M; Barrish JC; Dodd JH; Schieven GL; Leftheris K
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2652-7. PubMed ID: 18359226
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors.
    Ducray R; Ballard P; Barlaam BC; Hickinson MD; Kettle JG; Ogilvie DJ; Trigwell CB
    Bioorg Med Chem Lett; 2008 Feb; 18(3):959-62. PubMed ID: 18182285
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases.
    Bagi CM; Roberts GW; Andresen CJ
    Cancer; 2008 May; 112(10):2313-21. PubMed ID: 18348298
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.
    Lulo J; Yuzawa S; Schlessinger J
    Biochem Biophys Res Commun; 2009 Jun; 383(3):347-52. PubMed ID: 19358827
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.