BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 18972468)

  • 1. Small-molecule inhibitors of PDK1.
    Peifer C; Alessi DR
    ChemMedChem; 2008 Dec; 3(12):1810-38. PubMed ID: 18972468
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
    Najafov A; Sommer EM; Axten JM; Deyoung MP; Alessi DR
    Biochem J; 2011 Jan; 433(2):357-69. PubMed ID: 21087210
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
    Feldman RI; Wu JM; Polokoff MA; Kochanny MJ; Dinter H; Zhu D; Biroc SL; Alicke B; Bryant J; Yuan S; Buckman BO; Lentz D; Ferrer M; Whitlow M; Adler M; Finster S; Chang Z; Arnaiz DO
    J Biol Chem; 2005 May; 280(20):19867-74. PubMed ID: 15772071
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.
    Gagliardi PA; di Blasio L; Orso F; Seano G; Sessa R; Taverna D; Bussolino F; Primo L
    Neoplasia; 2012 Aug; 14(8):719-31. PubMed ID: 22952425
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Modulation of PI3K/PTEN Pathway Does Not Affect Catalytic Activity of PDK1 in Jurkat Cells.
    Yang KJ; Piao L; Shin S; Shin SY; Li Y; Lee H; Tran Q; Park J; Hong S; Brazil DP; Hemmings BA; Kim SH; Park J
    Anticancer Res; 2017 Oct; 37(10):5415-5423. PubMed ID: 28982851
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Targeting PDK1 in cancer.
    Raimondi C; Falasca M
    Curr Med Chem; 2011; 18(18):2763-9. PubMed ID: 21568903
    [TBL] [Abstract][Full Text] [Related]  

  • 7. PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway.
    Zhang X; Zhong S
    Anticancer Agents Med Chem; 2020; 20(7):828-833. PubMed ID: 32188393
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line.
    Arico S; Pattingre S; Bauvy C; Gane P; Barbat A; Codogno P; Ogier-Denis E
    J Biol Chem; 2002 Aug; 277(31):27613-21. PubMed ID: 12000750
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.
    Chen T; Sorna V; Choi S; Call L; Bearss J; Carpenter K; Warner SL; Sharma S; Bearss DJ; Vankayalapati H
    Bioorg Med Chem Lett; 2017 Dec; 27(24):5473-5480. PubMed ID: 29150397
    [TBL] [Abstract][Full Text] [Related]  

  • 10. For a PDK1 inhibitor, the substrate matters.
    Knight ZA
    Biochem J; 2011 Jan; 433(2):e1-2. PubMed ID: 21175429
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.
    Xu Z; Nagashima K; Sun D; Rush T; Northrup A; Andersen JN; Kariv I; Bobkova EV
    J Biomol Screen; 2009 Dec; 14(10):1257-62. PubMed ID: 19822882
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.
    Scortegagna M; Ruller C; Feng Y; Lazova R; Kluger H; Li JL; De SK; Rickert R; Pellecchia M; Bosenberg M; Ronai ZA
    Oncogene; 2014 Aug; 33(34):4330-9. PubMed ID: 24037523
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
    Schulze JO; Saladino G; Busschots K; Neimanis S; Süß E; Odadzic D; Zeuzem S; Hindie V; Herbrand AK; Lisa MN; Alzari PM; Gervasio FL; Biondi RM
    Cell Chem Biol; 2016 Oct; 23(10):1193-1205. PubMed ID: 27693059
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme.
    Sestito S; Nesi G; Daniele S; Martelli A; Digiacomo M; Borghini A; Pietra D; Calderone V; Lapucci A; Falasca M; Parrella P; Notarangelo A; Breschi MC; Macchia M; Martini C; Rapposelli S
    Eur J Med Chem; 2015 Nov; 105():274-88. PubMed ID: 26498573
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: possible role of metalloproteinases.
    Alcántara-Hernández R; Hernández-Méndez A; García-Sáinz JA
    Eur J Pharmacol; 2014 Oct; 740():88-96. PubMed ID: 25016091
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
    Sturm EM; Parzmair GP; Radnai B; Frei RB; Sturm GJ; Hammer A; Schuligoi R; Lippe IT; Heinemann A
    Eur J Immunol; 2015 May; 45(5):1548-59. PubMed ID: 25645675
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein.
    Zhang J; Yang C; Zhou F; Chen X
    Oncol Rep; 2018 Jun; 39(6):2951-2959. PubMed ID: 29658600
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Apoptosis-induced effects of extract from Artemisia annua Linné by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells.
    Kim EJ; Kim GT; Kim BM; Lim EG; Kim SY; Kim YM
    BMC Complement Altern Med; 2017 Apr; 17(1):236. PubMed ID: 28454566
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242.
    Yang C; Huang X; Liu H; Xiao F; Wei J; You L; Qian W
    Oncotarget; 2017 Jun; 8(24):39185-39197. PubMed ID: 28402933
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
    Medina JR; Becker CJ; Blackledge CW; Duquenne C; Feng Y; Grant SW; Heerding D; Li WH; Miller WH; Romeril SP; Scherzer D; Shu A; Bobko MA; Chadderton AR; Dumble M; Gardiner CM; Gilbert S; Liu Q; Rabindran SK; Sudakin V; Xiang H; Brady PG; Campobasso N; Ward P; Axten JM
    J Med Chem; 2011 Mar; 54(6):1871-95. PubMed ID: 21341675
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.