BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

353 related articles for article (PubMed ID: 18974095)

  • 21. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
    Gan B; Sahin E; Jiang S; Sanchez-Aguilera A; Scott KL; Chin L; Williams DA; Kwiatkowski DJ; DePinho RA
    Proc Natl Acad Sci U S A; 2008 Dec; 105(49):19384-9. PubMed ID: 19052232
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex.
    Wang Y; Tang S; Wu Y; Wan X; Zhou M; Li H; Zha X
    IUBMB Life; 2020 May; 72(5):965-977. PubMed ID: 31958214
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.
    Smith EM; Finn SG; Tee AR; Browne GJ; Proud CG
    J Biol Chem; 2005 May; 280(19):18717-27. PubMed ID: 15772076
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Loss of TSC2 confers resistance to ceramide and nutrient deprivation.
    Guenther GG; Liu G; Ramirez MU; McMonigle RJ; Kim SM; McCracken AN; Joo Y; Ushach I; Nguyen NL; Edinger AL
    Oncogene; 2014 Apr; 33(14):1776-87. PubMed ID: 23604129
    [TBL] [Abstract][Full Text] [Related]  

  • 25. mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.
    Taneike M; Nishida K; Omiya S; Zarrinpashneh E; Misaka T; Kitazume-Taneike R; Austin R; Takaoka M; Yamaguchi O; Gambello MJ; Shah AM; Otsu K
    PLoS One; 2016; 11(3):e0152628. PubMed ID: 27023784
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation.
    Chuang YT; Fang LW; Lin-Feng MH; Chen RH; Lai MZ
    J Immunol; 2008 Mar; 180(5):3238-49. PubMed ID: 18292548
    [TBL] [Abstract][Full Text] [Related]  

  • 27. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.
    Shaw RJ
    Acta Physiol (Oxf); 2009 May; 196(1):65-80. PubMed ID: 19245654
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
    Kang YJ; Lu MK; Guan KL
    Cell Death Differ; 2011 Jan; 18(1):133-44. PubMed ID: 20616807
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.
    Miyazaki M; McCarthy JJ; Esser KA
    FEBS J; 2010 May; 277(9):2180-91. PubMed ID: 20412061
    [TBL] [Abstract][Full Text] [Related]  

  • 30. CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling.
    Liao WT; Chiang YJ; Yang-Yen HF; Hsu LC; Chang ZF; Yen JJY
    J Biol Chem; 2023 Dec; 299(12):105455. PubMed ID: 37949232
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A complex interplay between Akt, TSC2 and the two mTOR complexes.
    Huang J; Manning BD
    Biochem Soc Trans; 2009 Feb; 37(Pt 1):217-22. PubMed ID: 19143635
    [TBL] [Abstract][Full Text] [Related]  

  • 32. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.
    Dennis MD; Coleman CS; Berg A; Jefferson LS; Kimball SR
    Sci Signal; 2014 Jul; 7(335):ra68. PubMed ID: 25056877
    [TBL] [Abstract][Full Text] [Related]  

  • 33. NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.
    James MF; Han S; Polizzano C; Plotkin SR; Manning BD; Stemmer-Rachamimov AO; Gusella JF; Ramesh V
    Mol Cell Biol; 2009 Aug; 29(15):4250-61. PubMed ID: 19451225
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
    Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA
    J Biol Chem; 2013 May; 288(22):15687-98. PubMed ID: 23612979
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.
    Zech R; Kiontke S; Mueller U; Oeckinghaus A; Kümmel D
    J Biol Chem; 2016 Sep; 291(38):20008-20. PubMed ID: 27493206
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
    Parkhitko A; Myachina F; Morrison TA; Hindi KM; Auricchio N; Karbowniczek M; Wu JJ; Finkel T; Kwiatkowski DJ; Yu JJ; Henske EP
    Proc Natl Acad Sci U S A; 2011 Jul; 108(30):12455-60. PubMed ID: 21746920
    [TBL] [Abstract][Full Text] [Related]  

  • 37. MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
    Fawal MA; Brandt M; Djouder N
    Dev Cell; 2015 Apr; 33(1):67-81. PubMed ID: 25816988
    [TBL] [Abstract][Full Text] [Related]  

  • 38. PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
    Ranek MJ; Kokkonen-Simon KM; Chen A; Dunkerly-Eyring BL; Vera MP; Oeing CU; Patel CH; Nakamura T; Zhu G; Bedja D; Sasaki M; Holewinski RJ; Van Eyk JE; Powell JD; Lee DI; Kass DA
    Nature; 2019 Feb; 566(7743):264-269. PubMed ID: 30700906
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
    Huang J; Manning BD
    Biochem J; 2008 Jun; 412(2):179-90. PubMed ID: 18466115
    [TBL] [Abstract][Full Text] [Related]  

  • 40. TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.
    Rosengren T; Larsen LJ; Pedersen LB; Christensen ST; Møller LB
    Cell Mol Life Sci; 2018 Jul; 75(14):2663-2680. PubMed ID: 29396625
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 18.