BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 18977148)

  • 1. Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.
    Clement JA; Kitagaki J; Yang Y; Saucedo CJ; O'Keefe BR; Weissman AM; McKee TC; McMahon JB
    Bioorg Med Chem; 2008 Dec; 16(23):10022-8. PubMed ID: 18977148
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Additional cytotoxic pyridoacridine alkaloids from the ascidian Cystodytes violatinctus and biogenetic considerations.
    Bontemps N; Gattacceca F; Long C; Thomas OP; Banaigs B
    J Nat Prod; 2013 Sep; 76(9):1801-5. PubMed ID: 23961991
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
    Kitagaki J; Agama KK; Pommier Y; Yang Y; Weissman AM
    Mol Cancer Ther; 2008 Aug; 7(8):2445-54. PubMed ID: 18723490
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer.
    Weissman AM; Yang Y; Kitagaki J; Sasiela CA; Beutler JA; O'Keefe BR
    Ernst Schering Found Symp Proc; 2008; (1):171-90. PubMed ID: 19202599
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells.
    Yang Y; Ludwig RL; Jensen JP; Pierre SA; Medaglia MV; Davydov IV; Safiran YJ; Oberoi P; Kenten JH; Phillips AC; Weissman AM; Vousden KH
    Cancer Cell; 2005 Jun; 7(6):547-59. PubMed ID: 15950904
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Sebastianines A and B, novel biologically active pyridoacridine alkaloids from the Brazilian ascidian Cystodytes dellechiajei.
    Torres YR; Bugni TS; Berlinck RG; Ireland CM; Magalhães A; Ferreira AG; Moreira Da Rocha R
    J Org Chem; 2002 Jul; 67(15):5429-32. PubMed ID: 12126446
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors.
    Lai Z; Yang T; Kim YB; Sielecki TM; Diamond MA; Strack P; Rolfe M; Caligiuri M; Benfield PA; Auger KR; Copeland RA
    Proc Natl Acad Sci U S A; 2002 Nov; 99(23):14734-9. PubMed ID: 12407176
    [TBL] [Abstract][Full Text] [Related]  

  • 8. p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction.
    Medina-Medina I; Martínez-Sánchez M; Hernández-Monge J; Fahraeus R; Muller P; Olivares-Illana V
    Protein Sci; 2018 May; 27(5):976-986. PubMed ID: 29524278
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structures and antimicrobial activities of pyridoacridine alkaloids isolated from different chromotypes of the ascidian Cystodytes dellechiajei.
    Bontemps N; Bry D; López-Legentil S; Simon-Levert A; Long C; Banaigs B
    J Nat Prod; 2010 Jun; 73(6):1044-8. PubMed ID: 20491501
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction.
    Nakamura Y; Kato H; Nishikawa T; Iwasaki N; Suwa Y; Rotinsulu H; Losung F; Maarisit W; Mangindaan RE; Morioka H; Yokosawa H; Tsukamoto S
    Org Lett; 2013 Jan; 15(2):322-5. PubMed ID: 23268733
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.
    Dickens MP; Roxburgh P; Hock A; Mezna M; Kellam B; Vousden KH; Fischer PM
    Bioorg Med Chem; 2013 Nov; 21(22):6868-77. PubMed ID: 24113239
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Quantitative assays of Mdm2 ubiquitin ligase activity and other ubiquitin-utilizing enzymes for inhibitor discovery.
    Auger KR; Copeland RA; Lai Z
    Methods Enzymol; 2005; 399():701-17. PubMed ID: 16338390
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26.
    Zhang Y; Wang J; Yuan Y; Zhang W; Guan W; Wu Z; Jin C; Chen H; Zhang L; Yang X; He F
    Nucleic Acids Res; 2010 Oct; 38(19):6544-54. PubMed ID: 20542919
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Diphenylpyrroles: Novel p53 activators.
    Gomha SM; Eldebss TM; Abdulla MM; Mayhoub AS
    Eur J Med Chem; 2014 Jul; 82():472-9. PubMed ID: 24934571
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer.
    Patel S; Player MR
    Expert Opin Investig Drugs; 2008 Dec; 17(12):1865-82. PubMed ID: 19012502
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1.
    Reuther C; Heinzle V; Nölting S; Herterich S; Hahner S; Halilovic E; Jeay S; Wuerthner JU; Aristizabal Prada ET; Spöttl G; Maurer J; Auernhammer CJ
    Neuroendocrinology; 2018; 106(1):1-19. PubMed ID: 27871087
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Abnormal p53-HDM2 interaction in hematological malignancy].
    Tabe Y; Kojima K
    Nihon Rinsho; 2014 Jun; 72(6):1042-6. PubMed ID: 25016801
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Proteasome inhibitors suppress the protein expression of mutant p53.
    Halasi M; Pandit B; Gartel AL
    Cell Cycle; 2014; 13(20):3202-6. PubMed ID: 25485499
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastoma cell line, from marine sponge Biemna fortis.
    Aoki S; Wei H; Matsui K; Rachmat R; Kobayashi M
    Bioorg Med Chem; 2003 May; 11(9):1969-73. PubMed ID: 12670647
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lissoclibadins 4-7, polysulfur aromatic alkaloids from the Indonesian ascidian Lissoclinum cf. badium.
    Nakazawa T; Xu J; Nishikawa T; Oda T; Fujita A; Ukai K; Mangindaan RE; Rotinsulu H; Kobayashi H; Namikoshi M
    J Nat Prod; 2007 Mar; 70(3):439-42. PubMed ID: 17269824
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.