These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 18979396)

  • 1. Toward an improved prediction of human in vivo brain penetration.
    Summerfield SG; Lucas AJ; Porter RA; Jeffrey P; Gunn RN; Read KR; Stevens AJ; Metcalf AC; Osuna MC; Kilford PJ; Passchier J; Ruffo AD
    Xenobiotica; 2008 Dec; 38(12):1518-35. PubMed ID: 18979396
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction.
    Summerfield SG; Read K; Begley DJ; Obradovic T; Hidalgo IJ; Coggon S; Lewis AV; Porter RA; Jeffrey P
    J Pharmacol Exp Ther; 2007 Jul; 322(1):205-13. PubMed ID: 17405866
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.
    Summerfield SG; Stevens AJ; Cutler L; del Carmen Osuna M; Hammond B; Tang SP; Hersey A; Spalding DJ; Jeffrey P
    J Pharmacol Exp Ther; 2006 Mar; 316(3):1282-90. PubMed ID: 16330496
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Progress in brain penetration evaluation in drug discovery and development.
    Liu X; Chen C; Smith BJ
    J Pharmacol Exp Ther; 2008 May; 325(2):349-56. PubMed ID: 18203948
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Applications of a blood-brain barrier technology platform to predict CNS penetration of various chemotherapeutic agents. 1. Anti-infective drugs.
    Adenot M; Perriere N; Scherrmann JM; Lahana R
    Chemotherapy; 2007; 53(1):70-2. PubMed ID: 17202814
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.
    Hsiao P; Bui T; Ho RJ; Unadkat JD
    Drug Metab Dispos; 2008 Mar; 36(3):481-4. PubMed ID: 18057117
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept.
    Reichel A
    Chem Biodivers; 2009 Nov; 6(11):2030-49. PubMed ID: 19937839
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ionization-specific QSAR models of blood-brain penetration of drugs.
    Lanevskij K; Japertas P; Didziapetris R; Petrauskas A
    Chem Biodivers; 2009 Nov; 6(11):2050-4. PubMed ID: 19937840
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Methods to assess drug permeability across the blood-brain barrier.
    Nicolazzo JA; Charman SA; Charman WN
    J Pharm Pharmacol; 2006 Mar; 58(3):281-93. PubMed ID: 16536894
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Strategies to optimize brain penetration in drug discovery.
    Liu X; Chen C
    Curr Opin Drug Discov Devel; 2005 Jul; 8(4):505-12. PubMed ID: 16022187
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms.
    Chen H; Winiwarter S; Fridén M; Antonsson M; Engkvist O
    J Mol Graph Model; 2011 Aug; 29(8):985-95. PubMed ID: 21571561
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Applications of a blood-brain barrier technology platform to predict CNS penetration of various chemotherapeutic agents. 2. Cationic peptide vectors for brain delivery.
    Adenot M; Merida P; Lahana R
    Chemotherapy; 2007; 53(1):73-6. PubMed ID: 17202815
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Rapid screening of blood-brain barrier penetration of drugs using the immobilized artificial membrane phosphatidylcholine column chromatography.
    Yoon CH; Kim SJ; Shin BS; Lee KC; Yoo SD
    J Biomol Screen; 2006 Feb; 11(1):13-20. PubMed ID: 16314407
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans.
    Brunner M; Langer O; Sunder-Plassmann R; Dobrozemsky G; Müller U; Wadsak W; Krcal A; Karch R; Mannhalter C; Dudczak R; Kletter K; Steiner I; Baumgartner C; Müller M
    Clin Pharmacol Ther; 2005 Aug; 78(2):182-90. PubMed ID: 16084852
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.
    Maurer TS; Debartolo DB; Tess DA; Scott DO
    Drug Metab Dispos; 2005 Jan; 33(1):175-81. PubMed ID: 15502010
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport.
    Syvänen S; Lindhe O; Palner M; Kornum BR; Rahman O; Långström B; Knudsen GM; Hammarlund-Udenaes M
    Drug Metab Dispos; 2009 Mar; 37(3):635-43. PubMed ID: 19047468
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.
    Caruso A; Alvarez-Sánchez R; Hillebrecht A; Poirier A; Schuler F; Lavé T; Funk C; Belli S
    Biochem Pharmacol; 2013 Jun; 85(11):1684-99. PubMed ID: 23454189
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations?
    Hammarlund-Udenaes M
    Basic Clin Pharmacol Toxicol; 2010 Mar; 106(3):215-20. PubMed ID: 20050843
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Central nervous system distribution kinetics of indinavir in rats.
    Hamidi M
    J Pharm Pharmacol; 2007 Aug; 59(8):1077-85. PubMed ID: 17725849
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [Blood plasma proteins and drug transport across the hemato-encephalic barrier].
    Lutsevich AN; Bender KI; Kupchikov VV
    Farmakol Toksikol; 1991; 54(1):70-6. PubMed ID: 1860509
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.