188 related articles for article (PubMed ID: 18986018)
1. [Evaluation of in vitro antibacterial activity of fosmidomycin and its derivatives].
Shtannikov AV; Sergeeva EE; Biketov SF; Ostrovskiĭ DN
Antibiot Khimioter; 2007; 52(7-8):3-9. PubMed ID: 18986018
[TBL] [Abstract][Full Text] [Related]
2. Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.
Singh N; Chevé G; Avery MA; McCurdy CR
Curr Pharm Des; 2007; 13(11):1161-77. PubMed ID: 17430177
[TBL] [Abstract][Full Text] [Related]
3. Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Woo YH; Fernandes RP; Proteau PJ
Bioorg Med Chem; 2006 Apr; 14(7):2375-85. PubMed ID: 16310360
[TBL] [Abstract][Full Text] [Related]
4. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.
Dhiman RK; Schaeffer ML; Bailey AM; Testa CA; Scherman H; Crick DC
J Bacteriol; 2005 Dec; 187(24):8395-402. PubMed ID: 16321944
[TBL] [Abstract][Full Text] [Related]
5. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Mercklé L; de Andrés-Gómez A; Dick B; Cox RJ; Godfrey CR
Chembiochem; 2005 Oct; 6(10):1866-74. PubMed ID: 16116659
[TBL] [Abstract][Full Text] [Related]
6. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.
Proteau PJ
Bioorg Chem; 2004 Dec; 32(6):483-93. PubMed ID: 15530989
[TBL] [Abstract][Full Text] [Related]
7. Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.
Sanders S; Bartee D; Harrison MJ; Phillips PD; Koppisch AT; Freel Meyers CL
PLoS One; 2018; 13(5):e0197638. PubMed ID: 29771999
[TBL] [Abstract][Full Text] [Related]
8. Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase.
Perruchon J; Ortmann R; Altenkämper M; Silber K; Wiesner J; Jomaa H; Klebe G; Schlitzer M
ChemMedChem; 2008 Aug; 3(8):1232-41. PubMed ID: 18470849
[TBL] [Abstract][Full Text] [Related]
9. Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
Takenoya M; Ohtaki A; Noguchi K; Endo K; Sasaki Y; Ohsawa K; Yajima S; Yohda M
J Struct Biol; 2010 Jun; 170(3):532-9. PubMed ID: 20353826
[TBL] [Abstract][Full Text] [Related]
10. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.
Altincicek B; Hintz M; Sanderbrand S; Wiesner J; Beck E; Jomaa H
FEMS Microbiol Lett; 2000 Sep; 190(2):329-33. PubMed ID: 11034300
[TBL] [Abstract][Full Text] [Related]
11. α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues.
Dreneau A; Krebs FS; Munier M; Ngov C; Tritsch D; Lièvremont D; Rohmer M; Grosdemange-Billiard C
Molecules; 2021 Aug; 26(16):. PubMed ID: 34443699
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors.
Jackson ER; Dowd CS
Curr Top Med Chem; 2012; 12(7):706-28. PubMed ID: 22283814
[TBL] [Abstract][Full Text] [Related]
13. Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.
Ortmann R; Wiesner J; Silber K; Klebe G; Jomaa H; Schlitzer M
Arch Pharm (Weinheim); 2007 Sep; 340(9):483-90. PubMed ID: 17806130
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Andaloussi M; Henriksson LM; Więckowska A; Lindh M; Björkelid C; Larsson AM; Suresh S; Iyer H; Srinivasa BR; Bergfors T; Unge T; Mowbray SL; Larhed M; Jones TA; Karlén A
J Med Chem; 2011 Jul; 54(14):4964-76. PubMed ID: 21678907
[TBL] [Abstract][Full Text] [Related]
15. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.
Zhang B; Watts KM; Hodge D; Kemp LM; Hunstad DA; Hicks LM; Odom AR
Biochemistry; 2011 May; 50(17):3570-7. PubMed ID: 21438569
[TBL] [Abstract][Full Text] [Related]
16. A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
Humnabadkar V; Jha RK; Ghatnekar N; De Sousa SM
J Biomol Screen; 2011 Mar; 16(3):303-12. PubMed ID: 21335601
[TBL] [Abstract][Full Text] [Related]
17. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase.
Zinglé C; Kuntz L; Tritsch D; Grosdemange-Billiard C; Rohmer M
J Org Chem; 2010 May; 75(10):3203-7. PubMed ID: 20429517
[TBL] [Abstract][Full Text] [Related]
18. N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR.
Gadakh B; Pouyez J; Wouters J; Venkatesham A; Cos P; Van Aerschot A
Bioorg Med Chem Lett; 2015 Apr; 25(7):1577-9. PubMed ID: 25726328
[TBL] [Abstract][Full Text] [Related]
19. Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Deng L; Sundriyal S; Rubio V; Shi ZZ; Song Y
J Med Chem; 2009 Nov; 52(21):6539-42. PubMed ID: 19888756
[TBL] [Abstract][Full Text] [Related]
20. Properties and inhibition of the first two enzymes of the non-mevalonate pathway of isoprenoid biosynthesis.
Mueller C; Schwender J; Zeidler J; Lichtenthaler HK
Biochem Soc Trans; 2000 Dec; 28(6):792-3. PubMed ID: 11171210
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
