BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

224 related articles for article (PubMed ID: 18988625)

  • 1. Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.
    Ui-Tei K; Naito Y; Nishi K; Juni A; Saigo K
    Nucleic Acids Res; 2008 Dec; 36(22):7100-9. PubMed ID: 18988625
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Is the Efficiency of RNA Silencing Evolutionarily Regulated?
    Ui-Tei K
    Int J Mol Sci; 2016 May; 17(5):. PubMed ID: 27187367
    [TBL] [Abstract][Full Text] [Related]  

  • 3. siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect.
    Naito Y; Yoshimura J; Morishita S; Ui-Tei K
    BMC Bioinformatics; 2009 Nov; 10():392. PubMed ID: 19948054
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Thermodynamic Control of Small RNA-Mediated Gene Silencing.
    Ui-Tei K; Nishi K; Takahashi T; Nagasawa T
    Front Genet; 2012; 3():101. PubMed ID: 22675333
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
    Li F; Pallan PS; Maier MA; Rajeev KG; Mathieu SL; Kreutz C; Fan Y; Sanghvi J; Micura R; Rozners E; Manoharan M; Egli M
    Nucleic Acids Res; 2007; 35(19):6424-38. PubMed ID: 17881374
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects.
    Kamola PJ; Nakano Y; Takahashi T; Wilson PA; Ui-Tei K
    PLoS Comput Biol; 2015 Dec; 11(12):e1004656. PubMed ID: 26657993
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing.
    Dua P; Yoo JW; Kim S; Lee DK
    Mol Ther; 2011 Sep; 19(9):1676-87. PubMed ID: 21673662
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.
    Jackson AL; Burchard J; Schelter J; Chau BN; Cleary M; Lim L; Linsley PS
    RNA; 2006 Jul; 12(7):1179-87. PubMed ID: 16682560
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Comprehensive thermodynamic analysis of 3' double-nucleotide overhangs neighboring Watson-Crick terminal base pairs.
    O'Toole AS; Miller S; Haines N; Zink MC; Serra MJ
    Nucleic Acids Res; 2006; 34(11):3338-44. PubMed ID: 16820533
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing.
    Jackson AL; Burchard J; Leake D; Reynolds A; Schelter J; Guo J; Johnson JM; Lim L; Karpilow J; Nichols K; Marshall W; Khvorova A; Linsley PS
    RNA; 2006 Jul; 12(7):1197-205. PubMed ID: 16682562
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects.
    Kobayashi Y; Tian S; Ui-Tei K
    Genes (Basel); 2022 Feb; 13(2):. PubMed ID: 35205363
    [TBL] [Abstract][Full Text] [Related]  

  • 12. siRNA Design Software for a Target Gene-Specific RNA Interference.
    Naito Y; Ui-Tei K
    Front Genet; 2012; 3():102. PubMed ID: 22701467
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Correction to 'Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect'.
    Nucleic Acids Res; 2023 Jun; 51(11):5898. PubMed ID: 37194700
    [No Abstract]   [Full Text] [Related]  

  • 14. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
    Ui-Tei K; Naito Y; Zenno S; Nishi K; Yamato K; Takahashi F; Juni A; Saigo K
    Nucleic Acids Res; 2008 Apr; 36(7):2136-51. PubMed ID: 18267968
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Designing functional siRNA with reduced off-target effects.
    Naito Y; Ui-Tei K
    Methods Mol Biol; 2013; 942():57-68. PubMed ID: 23027045
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selection of Chemical Modifications in the siRNA Seed Region That Repress Off-Target Effect.
    Kobayashi Y; Miyamoto K; Aida M; Ui-Tei K
    Methods Mol Biol; 2021; 2282():17-30. PubMed ID: 33928567
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Terminal Duplex Stability and Nucleotide Identity Differentially Control siRNA Loading and Activity in RNA Interference.
    Angart PA; Carlson RJ; Adu-Berchie K; Walton SP
    Nucleic Acid Ther; 2016 Oct; 26(5):309-317. PubMed ID: 27399870
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A computational study of off-target effects of RNA interference.
    Qiu S; Adema CM; Lane T
    Nucleic Acids Res; 2005; 33(6):1834-47. PubMed ID: 15800213
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence for a DNA triplex in a recombination-like motif: I. Recognition of Watson-Crick base pairs by natural bases in a high-stability triplex.
    Walter A; Schütz H; Simon H; Birch-Hirschfeld E
    J Mol Recognit; 2001; 14(2):122-39. PubMed ID: 11301482
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Modification of the siRNA passenger strand by 5-nitroindole dramatically reduces its off-target effects.
    Zhang J; Zheng J; Lu C; Du Q; Liang Z; Xi Z
    Chembiochem; 2012 Sep; 13(13):1940-5. PubMed ID: 22887813
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.