These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 18992820)

  • 1. Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
    Warby SC; Doty CN; Graham RK; Shively J; Singaraja RR; Hayden MR
    Mol Cell Neurosci; 2009 Feb; 40(2):121-7. PubMed ID: 18992820
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
    Warby SC; Doty CN; Graham RK; Carroll JB; Yang YZ; Singaraja RR; Overall CM; Hayden MR
    Hum Mol Genet; 2008 Aug; 17(15):2390-404. PubMed ID: 18445618
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
    Graham RK; Deng Y; Slow EJ; Haigh B; Bissada N; Lu G; Pearson J; Shehadeh J; Bertram L; Murphy Z; Warby SC; Doty CN; Roy S; Wellington CL; Leavitt BR; Raymond LA; Nicholson DW; Hayden MR
    Cell; 2006 Jun; 125(6):1179-91. PubMed ID: 16777606
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.
    Pardo R; Colin E; Régulier E; Aebischer P; Déglon N; Humbert S; Saudou F
    J Neurosci; 2006 Feb; 26(5):1635-45. PubMed ID: 16452687
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Preventing formation of toxic N-terminal huntingtin fragments through antisense oligonucleotide-mediated protein modification.
    Evers MM; Tran HD; Zalachoras I; Meijer OC; den Dunnen JT; van Ommen GJ; Aartsma-Rus A; van Roon-Mom WM
    Nucleic Acid Ther; 2014 Feb; 24(1):4-12. PubMed ID: 24380395
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
    Tanaka Y; Igarashi S; Nakamura M; Gafni J; Torcassi C; Schilling G; Crippen D; Wood JD; Sawa A; Jenkins NA; Copeland NG; Borchelt DR; Ross CA; Ellerby LM
    Neurobiol Dis; 2006 Feb; 21(2):381-91. PubMed ID: 16150600
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.
    Graham RK; Deng Y; Pouladi MA; Vaid K; Ehrnhoefer D; Southwell AL; Bissada N; Franciosi S; Hayden MR
    J Huntingtons Dis; 2012; 1(2):243-60. PubMed ID: 25063333
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.
    Graham RK; Deng Y; Carroll J; Vaid K; Cowan C; Pouladi MA; Metzler M; Bissada N; Wang L; Faull RL; Gray M; Yang XW; Raymond LA; Hayden MR
    J Neurosci; 2010 Nov; 30(45):15019-29. PubMed ID: 21068307
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A cellular model that recapitulates major pathogenic steps of Huntington's disease.
    Lunkes A; Mandel JL
    Hum Mol Genet; 1998 Sep; 7(9):1355-61. PubMed ID: 9700187
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
    Hackam AS; Singaraja R; Zhang T; Gan L; Hayden MR
    Hum Mol Genet; 1999 Jan; 8(1):25-33. PubMed ID: 9887328
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.
    Tebbenkamp AT; Xu G; Siemienski ZB; Janus C; Fromholt SE; Brown HH; Swing D; Tessarollo L; Borchelt DR
    J Huntingtons Dis; 2014; 3(1):73-86. PubMed ID: 25062766
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.
    Lunkes A; Lindenberg KS; Ben-Haïem L; Weber C; Devys D; Landwehrmeyer GB; Mandel JL; Trottier Y
    Mol Cell; 2002 Aug; 10(2):259-69. PubMed ID: 12191472
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
    Warby SC; Chan EY; Metzler M; Gan L; Singaraja RR; Crocker SF; Robertson HA; Hayden MR
    Hum Mol Genet; 2005 Jun; 14(11):1569-77. PubMed ID: 15843398
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
    Waldron-Roby E; Ratovitski T; Wang X; Jiang M; Watkin E; Arbez N; Graham RK; Hayden MR; Hou Z; Mori S; Swing D; Pletnikov M; Duan W; Tessarollo L; Ross CA
    J Neurosci; 2012 Jan; 32(1):183-93. PubMed ID: 22219281
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.
    Ratovitski T; Gucek M; Jiang H; Chighladze E; Waldron E; D'Ambola J; Hou Z; Liang Y; Poirier MA; Hirschhorn RR; Graham R; Hayden MR; Cole RN; Ross CA
    J Biol Chem; 2009 Apr; 284(16):10855-67. PubMed ID: 19204007
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutant protein in Huntington disease is resistant to proteolysis in affected brain.
    Dyer RB; McMurray CT
    Nat Genet; 2001 Nov; 29(3):270-8. PubMed ID: 11600884
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.
    Rangone H; Poizat G; Troncoso J; Ross CA; MacDonald ME; Saudou F; Humbert S
    Eur J Neurosci; 2004 Jan; 19(2):273-9. PubMed ID: 14725621
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
    Kratter IH; Zahed H; Lau A; Tsvetkov AS; Daub AC; Weiberth KF; Gu X; Saudou F; Humbert S; Yang XW; Osmand A; Steffan JS; Masliah E; Finkbeiner S
    J Clin Invest; 2016 Sep; 126(9):3585-97. PubMed ID: 27525439
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
    Zala D; Colin E; Rangone H; Liot G; Humbert S; Saudou F
    Hum Mol Genet; 2008 Dec; 17(24):3837-46. PubMed ID: 18772195
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Complex interplay between the length and composition of the huntingtin-derived peptides modulates the intracellular behavior of the N-terminal fragments of mutant huntingtin.
    Milewski M; Gawliński P; Bąk D; Matysiak A; Bal J
    Eur J Cell Biol; 2015 May; 94(5):179-89. PubMed ID: 25773959
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.