These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

323 related articles for article (PubMed ID: 19002789)

  • 21. Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
    Wessel I; Jensen LH; Jensen PB; Falck J; Rose A; Roerth M; Nitiss JL; Sehested M
    Cancer Res; 1999 Jul; 59(14):3442-50. PubMed ID: 10416608
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.
    Utsugi T; Mattern MR; Mirabelli CK; Hanna N
    Cancer Res; 1990 May; 50(9):2636-40. PubMed ID: 2158396
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Increase in topoisomerase-II-mediated DNA breaks and cytotoxicity of VP16 in human U937 lymphoma cells pretreated with low doses of methotrexate.
    Lorico A; Boiocchi M; Rappa G; Sen S; Erba E; D'Incalci M
    Int J Cancer; 1990 Jan; 45(1):156-62. PubMed ID: 2153635
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Topoisomerases as anticancer targets.
    Delgado JL; Hsieh CM; Chan NL; Hiasa H
    Biochem J; 2018 Jan; 475(2):373-398. PubMed ID: 29363591
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.
    Per SR; Mattern MR; Mirabelli CK; Drake FH; Johnson RK; Crooke ST
    Mol Pharmacol; 1987 Jul; 32(1):17-25. PubMed ID: 3037302
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Contribution of topoisomerase I to conversion of single-strand into double-strand DNA breaks.
    Kowalska-Loth B; Bubko I; Komorowska B; Szumiel I; Staron K
    Mol Biol Rep; 1998 Jan; 25(1):21-6. PubMed ID: 9540064
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Cross-sensitivity to topoisomerase II inhibitors in cytotoxic drug-hypersensitive Chinese hamster ovary cell lines.
    Robson CN; Hoban PR; Harris AL; Hickson ID
    Cancer Res; 1987 Mar; 47(6):1560-5. PubMed ID: 2434220
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.
    Holm C; Covey JM; Kerrigan D; Pommier Y
    Cancer Res; 1989 Nov; 49(22):6365-8. PubMed ID: 2553254
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.
    Pommier Y; Pourquier P; Fan Y; Strumberg D
    Biochim Biophys Acta; 1998 Oct; 1400(1-3):83-105. PubMed ID: 9748515
    [TBL] [Abstract][Full Text] [Related]  

  • 30. DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide.
    Long BH; Musial ST; Brattain MG
    Cancer Res; 1986 Aug; 46(8):3809-16. PubMed ID: 3015377
    [TBL] [Abstract][Full Text] [Related]  

  • 31. DNA topoisomerases as anticancer drug targets: from the laboratory to the clinic.
    Holden JA
    Curr Med Chem Anticancer Agents; 2001 May; 1(1):1-25. PubMed ID: 12678768
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes.
    Swan RL; Cowell IG; Austin CA
    Mol Pharmacol; 2022 Jan; 101(1):24-32. PubMed ID: 34689119
    [TBL] [Abstract][Full Text] [Related]  

  • 33. A three-dimensional quantitative structure-activity relationship study of the inhibition of the ATPase activity and the strand passing catalytic activity of topoisomerase IIalpha by substituted purine analogs.
    Jensen LH; Liang H; Shoemaker R; Grauslund M; Sehested M; Hasinoff BB
    Mol Pharmacol; 2006 Nov; 70(5):1503-13. PubMed ID: 16880287
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice.
    Fortune JM; Osheroff N
    Prog Nucleic Acid Res Mol Biol; 2000; 64():221-53. PubMed ID: 10697411
    [TBL] [Abstract][Full Text] [Related]  

  • 35. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells.
    Jacob S; Aguado M; Fallik D; Praz F
    Cancer Res; 2001 Sep; 61(17):6555-62. PubMed ID: 11522654
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Structure-activity relationships of 9-anilinoacridines as inhibitors of human DNA topoisomerase II.
    Figgitt DP; Denny WA; Gamage SA; Ralph RK
    Anticancer Drug Des; 1994 Jun; 9(3):199-208. PubMed ID: 8031452
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.
    Strumberg D; Pilon AA; Smith M; Hickey R; Malkas L; Pommier Y
    Mol Cell Biol; 2000 Jun; 20(11):3977-87. PubMed ID: 10805740
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone.
    Krishnan P; Bastow KF
    Cancer Chemother Pharmacol; 2001 Mar; 47(3):187-98. PubMed ID: 11320661
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors.
    Bernstein NK; Karimi-Busheri F; Rasouli-Nia A; Mani R; Dianov G; Glover JN; Weinfeld M
    Anticancer Agents Med Chem; 2008 May; 8(4):358-67. PubMed ID: 18473721
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Effects of DNA topoisomerase IIα splice variants on acquired drug resistance.
    Elton TS; Ozer HG; Yalowich JC
    Cancer Drug Resist; 2020; 3(2):161-170. PubMed ID: 32566920
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 17.