255 related articles for article (PubMed ID: 19012393)
1. Assessment of additive/nonadditive effects in structure-activity relationships: implications for iterative drug design.
Patel Y; Gillet VJ; Howe T; Pastor J; Oyarzabal J; Willett P
J Med Chem; 2008 Dec; 51(23):7552-62. PubMed ID: 19012393
[TBL] [Abstract][Full Text] [Related]
2. Synthetic library design.
Huwe CM
Drug Discov Today; 2006 Aug; 11(15-16):763-7. PubMed ID: 16846805
[TBL] [Abstract][Full Text] [Related]
3. A critical appraisal of structure-based drug design.
Tintelnot-Blomley M; Lewis RA
IDrugs; 2006 Feb; 9(2):114-8. PubMed ID: 16523401
[TBL] [Abstract][Full Text] [Related]
4. Pyrazole CCK(1) receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity.
McClure K; Hack M; Huang L; Sehon C; Morton M; Li L; Barrett TD; Shankley N; Breitenbucher JG
Bioorg Med Chem Lett; 2006 Jan; 16(1):72-6. PubMed ID: 16236513
[TBL] [Abstract][Full Text] [Related]
5. Descriptor-free molecular discovery in large libraries by adaptive substituent reordering.
McAllister SR; Feng XJ; DiMaggio PA; Floudas CA; Rabinowitz JD; Rabitz H
Bioorg Med Chem Lett; 2008 Nov; 18(22):5967-70. PubMed ID: 18851908
[TBL] [Abstract][Full Text] [Related]
6. Pyrazole CCK(1) receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity.
Sehon C; McClure K; Hack M; Morton M; Gomez L; Li L; Barrett TD; Shankley N; Breitenbucher JG
Bioorg Med Chem Lett; 2006 Jan; 16(1):77-80. PubMed ID: 16236506
[TBL] [Abstract][Full Text] [Related]
7. The synergy between combinatorial chemistry and high-throughput screening.
Diller DJ
Curr Opin Drug Discov Devel; 2008 May; 11(3):346-55. PubMed ID: 18428088
[TBL] [Abstract][Full Text] [Related]
8. Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.
Sauer WH; Schwarz MK
J Chem Inf Comput Sci; 2003; 43(3):987-1003. PubMed ID: 12767158
[TBL] [Abstract][Full Text] [Related]
9. Complex molecules: do they add value?
Selzer P; Roth HJ; Ertl P; Schuffenhauer A
Curr Opin Chem Biol; 2005 Jun; 9(3):310-6. PubMed ID: 15939334
[TBL] [Abstract][Full Text] [Related]
10. Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
Newman DJ
J Med Chem; 2008 May; 51(9):2589-99. PubMed ID: 18393402
[No Abstract] [Full Text] [Related]
11. Selective optimization of side activities: another way for drug discovery.
Wermuth CG
J Med Chem; 2004 Mar; 47(6):1303-14. PubMed ID: 14998318
[No Abstract] [Full Text] [Related]
12. Natural product hybrids as new leads for drug discovery.
Tietze LF; Bell HP; Chandrasekhar S
Angew Chem Int Ed Engl; 2003 Sep; 42(34):3996-4028. PubMed ID: 12973759
[TBL] [Abstract][Full Text] [Related]
13. Expediting drug discovery: recent advances in fast medicinal chemistry--optimization of hits and leads.
Edwards PJ; Allart B; Andrews MJ; Clase JA; Menet C
Curr Opin Drug Discov Devel; 2006 Jul; 9(4):425-44. PubMed ID: 16889227
[TBL] [Abstract][Full Text] [Related]
14. Current directions in the evolution of compound libraries.
Webb TR
Curr Opin Drug Discov Devel; 2005 May; 8(3):303-8. PubMed ID: 15892244
[TBL] [Abstract][Full Text] [Related]
15. Receptor-assisted combinatorial chemistry: thermodynamics and kinetics in drug discovery.
Cheeseman JD; Corbett AD; Gleason JL; Kazlauskas RJ
Chemistry; 2005 Mar; 11(6):1708-16. PubMed ID: 15565741
[TBL] [Abstract][Full Text] [Related]
16. Design of diversity and focused combinatorial libraries in drug discovery.
Young SS; Ge N
Curr Opin Drug Discov Devel; 2004 May; 7(3):318-24. PubMed ID: 15216935
[TBL] [Abstract][Full Text] [Related]
17. Recent trends in library design: 'rational design' revisited.
Schnur DM
Curr Opin Drug Discov Devel; 2008 May; 11(3):375-80. PubMed ID: 18428091
[TBL] [Abstract][Full Text] [Related]
18. Metal complexes in medicinal chemistry: new vistas and challenges in drug design.
Thompson KH; Orvig C
Dalton Trans; 2006 Feb; (6):761-4. PubMed ID: 16437168
[TBL] [Abstract][Full Text] [Related]
19. A screening study of ChirBase molecular database to explore the expanded chiral pool derived from the application of chiral chromatography.
Piras P; Roussel C
J Pharm Biomed Anal; 2008 Apr; 46(5):839-47. PubMed ID: 17942261
[TBL] [Abstract][Full Text] [Related]
20. The hidden component of size in two-dimensional fragment descriptors: side effects on sampling in bioactive libraries.
Dixon SL; Koehler RT
J Med Chem; 1999 Jul; 42(15):2887-900. PubMed ID: 10425098
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
