These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

218 related articles for article (PubMed ID: 19014680)

  • 1. Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.
    Voisin L; Julien C; Duhamel S; Gopalbhai K; Claveau I; Saba-El-Leil MK; Rodrigue-Gervais IG; Gaboury L; Lamarre D; Basik M; Meloche S
    BMC Cancer; 2008 Nov; 8():337. PubMed ID: 19014680
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
    Duhamel S; Hébert J; Gaboury L; Bouchard A; Simon R; Sauter G; Basik M; Meloche S
    Cancer Res; 2012 Feb; 72(3):626-35. PubMed ID: 22298595
    [TBL] [Abstract][Full Text] [Related]  

  • 3. MEK1 and MEK2 isoforms regulate distinct functions in pancreatic cancer cells.
    Zhou L; Tan X; Kamohara H; Wang W; Wang B; Liu J; Egami H; Baba H; Dai X
    Oncol Rep; 2010 Jul; 24(1):251-5. PubMed ID: 20514469
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis.
    Lemieux E; Bergeron S; Durand V; Asselin C; Saucier C; Rivard N
    Int J Cancer; 2009 Oct; 125(7):1575-86. PubMed ID: 19462441
    [TBL] [Abstract][Full Text] [Related]  

  • 5. RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo.
    Gailhouste L; Ezan F; Bessard A; Frémin C; Rageul J; Langouët S; Baffet G
    Int J Cancer; 2010 Mar; 126(6):1367-77. PubMed ID: 19816936
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression.
    Chen T; Yang M; Yu Z; Tang S; Wang C; Zhu X; Guo J; Li N; Zhang W; Hou J; Liu H; Han C; Liu Q; Gu Y; Qian C; Wan T; Cui L; Zhu M; Zheng W; Cao X
    Cancer Cell; 2014 May; 25(5):682-96. PubMed ID: 24746703
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.
    Scholl FA; Dumesic PA; Barragan DI; Harada K; Charron J; Khavari PA
    Cancer Res; 2009 May; 69(9):3772-8. PubMed ID: 19383924
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.
    Yamashita S; Tai P; Charron J; Ko C; Ascoli M
    Mol Endocrinol; 2011 Jul; 25(7):1211-22. PubMed ID: 21527500
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ERK1/2 can feedback-regulate cellular MEK1/2 levels.
    Hong SK; Wu PK; Karkhanis M; Park JI
    Cell Signal; 2015 Oct; 27(10):1939-48. PubMed ID: 26163823
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2.
    Zhang H; Feng H; Luo L; Zhou Q; Luo Z; Peng Y
    Virus Res; 2010 Jun; 150(1-2):22-7. PubMed ID: 20172001
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells.
    Shama J; Garcia-Medina R; Pouysségur J; Vial E
    Biochem Biophys Res Commun; 2008 Aug; 372(4):845-9. PubMed ID: 18533112
    [TBL] [Abstract][Full Text] [Related]  

  • 12. MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.
    Caunt CJ; Sale MJ; Smith PD; Cook SJ
    Nat Rev Cancer; 2015 Oct; 15(10):577-92. PubMed ID: 26399658
    [TBL] [Abstract][Full Text] [Related]  

  • 13. MEK2 controls the activation of MKK3/MKK6-p38 axis involved in the MDA-MB-231 breast cancer cell survival: Correlation with cyclin D1 expression.
    Huth HW; Albarnaz JD; Torres AA; Bonjardim CA; Ropert C
    Cell Signal; 2016 Sep; 28(9):1283-1291. PubMed ID: 27181679
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
    Catalanotti F; Reyes G; Jesenberger V; Galabova-Kovacs G; de Matos Simoes R; Carugo O; Baccarini M
    Nat Struct Mol Biol; 2009 Mar; 16(3):294-303. PubMed ID: 19219045
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2.
    Piao C; Jin M; Kim HB; Lee SM; Amatya PN; Hyun JW; Chang IY; You HJ
    Oncogene; 2009 May; 28(21):2173-84. PubMed ID: 19398949
    [TBL] [Abstract][Full Text] [Related]  

  • 16. MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments.
    Skarpen E; Flinder LI; Rosseland CM; Orstavik S; Wierød L; Oksvold MP; Skålhegg BS; Huitfeldt HS
    FASEB J; 2008 Feb; 22(2):466-76. PubMed ID: 17928366
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
    Ohren JF; Chen H; Pavlovsky A; Whitehead C; Zhang E; Kuffa P; Yan C; McConnell P; Spessard C; Banotai C; Mueller WT; Delaney A; Omer C; Sebolt-Leopold J; Dudley DT; Leung IK; Flamme C; Warmus J; Kaufman M; Barrett S; Tecle H; Hasemann CA
    Nat Struct Mol Biol; 2004 Dec; 11(12):1192-7. PubMed ID: 15543157
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect.
    Aoidi R; Maltais A; Charron J
    Sci Signal; 2016 Jan; 9(412):ra9. PubMed ID: 26814233
    [TBL] [Abstract][Full Text] [Related]  

  • 19. MEK1 and MEK2 differentially regulate human insulin- and insulin glargine-induced human bladder cancer T24 cell proliferation.
    Liu SY; Liang Y; Lin TX; Su F; Liang WW; Uwe H; Li Y
    Chin Med J (Engl); 2012 Dec; 125(23):4197-201. PubMed ID: 23217386
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis.
    Bergeron S; Lemieux E; Durand V; Cagnol S; Carrier JC; Lussier JG; Boucher MJ; Rivard N
    Mol Cancer; 2010 Oct; 9():271. PubMed ID: 20942929
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.