223 related articles for article (PubMed ID: 19036728)
1. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
Placanica L; Tarassishin L; Yang G; Peethumnongsin E; Kim SH; Zheng H; Sisodia SS; Li YM
J Biol Chem; 2009 Jan; 284(5):2967-2977. PubMed ID: 19036728
[TBL] [Abstract][Full Text] [Related]
2. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
Kim M; Bezprozvanny I
Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
[TBL] [Abstract][Full Text] [Related]
3. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
4. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
[TBL] [Abstract][Full Text] [Related]
5. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Heilig EA; Xia W; Shen J; Kelleher RJ
J Biol Chem; 2010 Jul; 285(29):22350-9. PubMed ID: 20460383
[TBL] [Abstract][Full Text] [Related]
6. Assembly of the presenilin γ-/ε-secretase complex.
St George-Hyslop P; Fraser PE
J Neurochem; 2012 Jan; 120 Suppl 1():84-88. PubMed ID: 22122073
[TBL] [Abstract][Full Text] [Related]
7. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
[TBL] [Abstract][Full Text] [Related]
8. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
Fukumori A; Fluhrer R; Steiner H; Haass C
J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
[TBL] [Abstract][Full Text] [Related]
9. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
Cacquevel M; Aeschbach L; Houacine J; Fraering PC
PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
[TBL] [Abstract][Full Text] [Related]
10. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
Lai MT; Chen E; Crouthamel MC; DiMuzio-Mower J; Xu M; Huang Q; Price E; Register RB; Shi XP; Donoviel DB; Bernstein A; Hazuda D; Gardell SJ; Li YM
J Biol Chem; 2003 Jun; 278(25):22475-81. PubMed ID: 12684521
[TBL] [Abstract][Full Text] [Related]
11. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
12. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M; Sahara N; Mizoroki T; Funamoto S; Morishima-Kawashima M; Kudo T; Takeda M; Ihara Y; Ichinose H; Takashima A
J Biol Chem; 2008 Jun; 283(24):16488-96. PubMed ID: 18430735
[TBL] [Abstract][Full Text] [Related]
13. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
[TBL] [Abstract][Full Text] [Related]
14. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
[TBL] [Abstract][Full Text] [Related]
15. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
Czirr E; Leuchtenberger S; Dorner-Ciossek C; Schneider A; Jucker M; Koo EH; Pietrzik CU; Baumann K; Weggen S
J Biol Chem; 2007 Aug; 282(34):24504-13. PubMed ID: 17573346
[TBL] [Abstract][Full Text] [Related]
16. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
[TBL] [Abstract][Full Text] [Related]
17. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
eNeuro; 2021; 8(2):. PubMed ID: 33608391
[TBL] [Abstract][Full Text] [Related]
18. Activation and intrinsic gamma-secretase activity of presenilin 1.
Ahn K; Shelton CC; Tian Y; Zhang X; Gilchrist ML; Sisodia SS; Li YM
Proc Natl Acad Sci U S A; 2010 Dec; 107(50):21435-40. PubMed ID: 21115843
[TBL] [Abstract][Full Text] [Related]
19. Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.
Meckler X; Checler F
J Biol Chem; 2016 Jun; 291(24):12821-12837. PubMed ID: 27059953
[TBL] [Abstract][Full Text] [Related]
20. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Page RM; Baumann K; Tomioka M; Pérez-Revuelta BI; Fukumori A; Jacobsen H; Flohr A; Luebbers T; Ozmen L; Steiner H; Haass C
J Biol Chem; 2008 Jan; 283(2):677-83. PubMed ID: 17962197
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]