BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

261 related articles for article (PubMed ID: 19047162)

  • 1. Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.
    Koomoa DL; Yco LP; Borsics T; Wallick CJ; Bachmann AS
    Cancer Res; 2008 Dec; 68(23):9825-31. PubMed ID: 19047162
    [TBL] [Abstract][Full Text] [Related]  

  • 2. AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport.
    Samal K; Zhao P; Kendzicky A; Yco LP; McClung H; Gerner E; Burns M; Bachmann AS; Sholler G
    Int J Cancer; 2013 Sep; 133(6):1323-33. PubMed ID: 23457004
    [TBL] [Abstract][Full Text] [Related]  

  • 3. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
    Koomoa DL; Geerts D; Lange I; Koster J; Pegg AE; Feith DJ; Bachmann AS
    Int J Oncol; 2013 Apr; 42(4):1219-28. PubMed ID: 23440295
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells.
    Wallick CJ; Gamper I; Thorne M; Feith DJ; Takasaki KY; Wilson SM; Seki JA; Pegg AE; Byus CV; Bachmann AS
    Oncogene; 2005 Aug; 24(36):5606-18. PubMed ID: 16007177
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma.
    Saulnier Sholler GL; Gerner EW; Bergendahl G; MacArthur RB; VanderWerff A; Ashikaga T; Bond JP; Ferguson W; Roberts W; Wada RK; Eslin D; Kraveka JM; Kaplan J; Mitchell D; Parikh NS; Neville K; Sender L; Higgins T; Kawakita M; Hiramatsu K; Moriya SS; Bachmann AS
    PLoS One; 2015; 10(5):e0127246. PubMed ID: 26018967
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
    Schultz CR; Geerts D; Mooney M; El-Khawaja R; Koster J; Bachmann AS
    Biochem J; 2018 Jan; 475(2):531-545. PubMed ID: 29295892
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.
    Rounbehler RJ; Li W; Hall MA; Yang C; Fallahi M; Cleveland JL
    Cancer Res; 2009 Jan; 69(2):547-53. PubMed ID: 19147568
    [TBL] [Abstract][Full Text] [Related]  

  • 8. EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
    Ray RM; Bhattacharya S; Johnson LR
    Cell Signal; 2007 Dec; 19(12):2519-27. PubMed ID: 17825525
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma.
    Schultz CR; Swanson MA; Dowling TC; Bachmann AS
    Cancer Chemother Pharmacol; 2021 Oct; 88(4):607-617. PubMed ID: 34129075
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells.
    Ishola TA; Kang J; Qiao J; Evers BM; Chung DH
    Biochim Biophys Acta; 2007 Jun; 1770(6):927-32. PubMed ID: 17379415
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine.
    Qu N; Ignatenko NA; Yamauchi P; Stringer DE; Levenson C; Shannon P; Perrin S; Gerner EW
    Biochem J; 2003 Oct; 375(Pt 2):465-70. PubMed ID: 12859253
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
    Matters GL; Manni A; Bond JS
    Clin Exp Metastasis; 2005; 22(4):331-9. PubMed ID: 16170669
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3.
    Bhattacharya S; Ray RM; Johnson LR
    Biochem J; 2006 Aug; 397(3):437-47. PubMed ID: 16669788
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity.
    Bhattacharya S; Ray RM; Johnson LR
    Apoptosis; 2005 Aug; 10(4):759-76. PubMed ID: 16133867
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells.
    Pfeffer LM; Yang CH; Murti A; McCormack SA; Viar MJ; Ray RM; Johnson LR
    J Biol Chem; 2001 Dec; 276(49):45909-13. PubMed ID: 11590175
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.
    Dozza B; Smith MA; Perry G; Tabaton M; Strocchi P
    J Neurochem; 2004 Jun; 89(5):1224-32. PubMed ID: 15147515
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.
    Arumugam A; Weng Z; Talwelkar SS; Chaudhary SC; Kopelovich L; Elmets CA; Afaq F; Athar M
    PLoS One; 2013; 8(11):e80076. PubMed ID: 24260338
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion.
    Zhang HM; Rao JN; Guo X; Liu L; Zou T; Turner DJ; Wang JY
    J Biol Chem; 2004 May; 279(21):22539-47. PubMed ID: 15024023
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha.
    Stanic I; Facchini A; Borzì RM; Vitellozzi R; Stefanelli C; Goldring MB; Guarnieri C; Facchini A; Flamigni F
    J Cell Physiol; 2006 Jan; 206(1):138-46. PubMed ID: 15965903
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.
    Merali S; Clarkson AB
    Antimicrob Agents Chemother; 1996 Apr; 40(4):973-8. PubMed ID: 8849262
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.