BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

342 related articles for article (PubMed ID: 19047368)

  • 1. The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
    Patursky-Polischuk I; Stolovich-Rain M; Hausner-Hanochi M; Kasir J; Cybulski N; Avruch J; Rüegg MA; Hall MN; Meyuhas O
    Mol Cell Biol; 2009 Feb; 29(3):640-9. PubMed ID: 19047368
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.
    Miloslavski R; Cohen E; Avraham A; Iluz Y; Hayouka Z; Kasir J; Mudhasani R; Jones SN; Cybulski N; Rüegg MA; Larsson O; Gandin V; Rajakumar A; Topisirovic I; Meyuhas O
    J Mol Cell Biol; 2014 Jun; 6(3):255-66. PubMed ID: 24627160
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.
    Bilanges B; Argonza-Barrett R; Kolesnichenko M; Skinner C; Nair M; Chen M; Stokoe D
    Mol Cell Biol; 2007 Aug; 27(16):5746-64. PubMed ID: 17562867
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 5. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.
    Foster KG; Acosta-Jaquez HA; Romeo Y; Ekim B; Soliman GA; Carriere A; Roux PP; Ballif BA; Fingar DC
    J Biol Chem; 2010 Jan; 285(1):80-94. PubMed ID: 19864431
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.
    Smith EM; Finn SG; Tee AR; Browne GJ; Proud CG
    J Biol Chem; 2005 May; 280(19):18717-27. PubMed ID: 15772076
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
    Gau CL; Kato-Stankiewicz J; Jiang C; Miyamoto S; Guo L; Tamanoi F
    Mol Cancer Ther; 2005 Jun; 4(6):918-26. PubMed ID: 15956249
    [TBL] [Abstract][Full Text] [Related]  

  • 9. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
    Xie J; Ponuwei GA; Moore CE; Willars GB; Tee AR; Herbert TP
    Cell Signal; 2011 Dec; 23(12):1927-35. PubMed ID: 21763421
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phospholipase D1 is an effector of Rheb in the mTOR pathway.
    Sun Y; Fang Y; Yoon MS; Zhang C; Roccio M; Zwartkruis FJ; Armstrong M; Brown HA; Chen J
    Proc Natl Acad Sci U S A; 2008 Jun; 105(24):8286-91. PubMed ID: 18550814
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
    Inoki K; Li Y; Xu T; Guan KL
    Genes Dev; 2003 Aug; 17(15):1829-34. PubMed ID: 12869586
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
    Yoshida S; Hong S; Suzuki T; Nada S; Mannan AM; Wang J; Okada M; Guan KL; Inoki K
    J Biol Chem; 2011 Sep; 286(37):32651-60. PubMed ID: 21784859
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
    Garami A; Zwartkruis FJ; Nobukuni T; Joaquin M; Roccio M; Stocker H; Kozma SC; Hafen E; Bos JL; Thomas G
    Mol Cell; 2003 Jun; 11(6):1457-66. PubMed ID: 12820960
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs.
    Patursky-Polischuk I; Kasir J; Miloslavski R; Hayouka Z; Hausner-Hanochi M; Stolovich-Rain M; Tsukerman P; Biton M; Mudhasani R; Jones SN; Meyuhas O
    PLoS One; 2014; 9(10):e109410. PubMed ID: 25338081
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
    Kang YJ; Lu MK; Guan KL
    Cell Death Differ; 2011 Jan; 18(1):133-44. PubMed ID: 20616807
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells.
    Lee PS; Tsang SW; Moses MA; Trayes-Gibson Z; Hsiao LL; Jensen R; Squillace R; Kwiatkowski DJ
    Am J Respir Cell Mol Biol; 2010 Feb; 42(2):227-34. PubMed ID: 19395678
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
    Neuman NA; Henske EP
    EMBO Mol Med; 2011 Apr; 3(4):189-200. PubMed ID: 21412983
    [TBL] [Abstract][Full Text] [Related]  

  • 18. PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
    Liu Z; Chen X; Wang Y; Peng H; Wang Y; Jing Y; Zhang H
    J Biol Chem; 2014 Oct; 289(43):29739-49. PubMed ID: 25164809
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts.
    Goncharova EA; James ML; Kudryashova TV; Goncharov DA; Krymskaya VP
    PLoS One; 2014; 9(10):e111476. PubMed ID: 25360538
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
    Karbowniczek M; Cash T; Cheung M; Robertson GP; Astrinidis A; Henske EP
    J Biol Chem; 2004 Jul; 279(29):29930-7. PubMed ID: 15150271
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.