BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 19075603)

  • 1. Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening.
    Urban DJ; Zheng W; Goker-Alpan O; Jadhav A; Lamarca ME; Inglese J; Sidransky E; Austin CP
    Comb Chem High Throughput Screen; 2008 Dec; 11(10):817-24. PubMed ID: 19075603
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide.
    Motabar O; Goldin E; Leister W; Liu K; Southall N; Huang W; Marugan JJ; Sidransky E; Zheng W
    Anal Bioanal Chem; 2012 Jan; 402(2):731-9. PubMed ID: 22033823
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase.
    Goldin E; Zheng W; Motabar O; Southall N; Choi JH; Marugan J; Austin CP; Sidransky E
    PLoS One; 2012; 7(1):e29861. PubMed ID: 22272254
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.
    Tropak MB; Kornhaber GJ; Rigat BA; Maegawa GH; Buttner JD; Blanchard JE; Murphy C; Tuske SJ; Coales SJ; Hamuro Y; Brown ED; Mahuran DJ
    Chembiochem; 2008 Nov; 9(16):2650-62. PubMed ID: 18972510
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibitor screening of pharmacological chaperones for lysosomal β-glucocerebrosidase by capillary electrophoresis.
    Shanmuganathan M; Britz-McKibbin P
    Anal Bioanal Chem; 2011 Mar; 399(8):2843-53. PubMed ID: 21286689
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.
    Zheng W; Padia J; Urban DJ; Jadhav A; Goker-Alpan O; Simeonov A; Goldin E; Auld D; LaMarca ME; Inglese J; Austin CP; Sidransky E
    Proc Natl Acad Sci U S A; 2007 Aug; 104(32):13192-7. PubMed ID: 17670938
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Fluorescent flow cytometric assay: a new diagnostic tool for measuring beta-glucocerebrosidase activity in Gaucher disease.
    Rudensky B; Paz E; Altarescu G; Raveh D; Elstein D; Zimran A
    Blood Cells Mol Dis; 2003; 30(1):97-9. PubMed ID: 12667991
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activity-Based Probes for Glycosidases: Profiling and Other Applications.
    Kuo CL; van Meel E; Kytidou K; Kallemeijn WW; Witte M; Overkleeft HS; Artola ME; Aerts JM
    Methods Enzymol; 2018; 598():217-235. PubMed ID: 29306436
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling.
    van Smeden J; Dijkhoff IM; Helder RWJ; Al-Khakany H; Boer DEC; Schreuder A; Kallemeijn WW; Absalah S; Overkleeft HS; Aerts JMFG; Bouwstra JA
    J Lipid Res; 2017 Dec; 58(12):2299-2309. PubMed ID: 29025868
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hydrophilic iminosugar active-site-specific chaperones increase residual glucocerebrosidase activity in fibroblasts from Gaucher patients.
    Chang HH; Asano N; Ishii S; Ichikawa Y; Fan JQ
    FEBS J; 2006 Sep; 273(17):4082-92. PubMed ID: 16934036
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.
    Jung O; Patnaik S; Marugan J; Sidransky E; Westbroek W
    Expert Rev Proteomics; 2016 May; 13(5):471-9. PubMed ID: 27098312
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1.
    Sharlow ER; Leimgruber S; Shun TY; Lazo JS
    Assay Drug Dev Technol; 2007 Dec; 5(6):723-35. PubMed ID: 18181689
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Glucocerebrosidase inhibitors for the treatment of Gaucher disease.
    Trapero A; Llebaria A
    Future Med Chem; 2013 Apr; 5(5):573-90. PubMed ID: 23573974
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A high-throughput, nonisotopic, competitive binding assay for kinases using nonselective inhibitor probes (ED-NSIP).
    Vainshtein I; Silveria S; Kaul P; Rouhani R; Eglen RM; Wang J
    J Biomol Screen; 2002 Dec; 7(6):507-14. PubMed ID: 14599348
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of a miniaturized 384-well high throughput screen for the detection of substrates of cytochrome P450 2D6 and 3A4 metabolism.
    Kariv I; Fereshteh MP; Oldenburg KR
    J Biomol Screen; 2001 Apr; 6(2):91-9. PubMed ID: 11689103
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).
    Schröter T; Minond D; Weiser A; Dao C; Habel J; Spicer T; Chase P; Baillargeon P; Scampavia L; Schürer S; Chung C; Mader C; Southern M; Tsinoremas N; LoGrasso P; Hodder P
    J Biomol Screen; 2008 Jan; 13(1):17-28. PubMed ID: 18227223
    [TBL] [Abstract][Full Text] [Related]  

  • 17. An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions - relevance for Gaucher disease.
    Atrian S; López-Viñas E; Gómez-Puertas P; Chabás A; Vilageliu L; Grinberg D
    Proteins; 2008 Feb; 70(3):882-91. PubMed ID: 17803231
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Promising results of the chaperone effect caused by imino sugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease.
    Sánchez-Ollé G; Duque J; Egido-Gabás M; Casas J; Lluch M; Chabás A; Grinberg D; Vilageliu L
    Blood Cells Mol Dis; 2009; 42(2):159-66. PubMed ID: 19167250
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A flow cytometric assay for lysosomal glucocerebrosidase.
    van Es HH; Veldwijk M; Havenga M; Valerio D
    Anal Biochem; 1997 May; 247(2):268-71. PubMed ID: 9177687
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 2,3-di-O-tetradecyl-1-O-(beta-D-glucopyranosyl)-sn-glycerol is a substrate for human glucocerebrosidase.
    Glew RH; Gopalan V; Hubbell CA; Devraj RV; Lawson RA; Diven WF; Mannock DA
    Biochem J; 1991 Mar; 274 ( Pt 2)(Pt 2):557-63. PubMed ID: 1900989
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.