BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

215 related articles for article (PubMed ID: 19081725)

  • 1. Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma receptor affinity and cytotoxic activity.
    Holl R; Schepmann D; Grünert R; Bednarski PJ; Wünsch B
    Bioorg Med Chem; 2009 Jan; 17(2):777-93. PubMed ID: 19081725
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity.
    Holl R; Schepmann D; Fröhlich R; Grünert R; Bednarski PJ; Wünsch B
    J Med Chem; 2009 Apr; 52(7):2126-37. PubMed ID: 19243173
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring.
    Holl R; Jung B; Schepmann D; Humpf HU; Grünert R; Bednarski PJ; Englberger W; Wünsch B
    ChemMedChem; 2009 Dec; 4(12):2111-22. PubMed ID: 19827086
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma receptor affinity and cytotoxic activity.
    Holl R; Schepmann D; Bednarski PJ; Grünert R; Wünsch B
    Bioorg Med Chem; 2009 Feb; 17(4):1445-55. PubMed ID: 19196515
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and biological evaluation of conformationally restricted σ(1) receptor ligands with 7,9-diazabicyclo[4.2.2]decane scaffold.
    Sunnam SK; Schepmann D; Rack E; Fröhlich R; Korpis K; Bednarski PJ; Wünsch B
    Org Biomol Chem; 2010 Dec; 8(24):5525-40. PubMed ID: 20953473
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of bridged piperazines with sigma receptor affinity.
    Weigl M; Wünsch B
    Eur J Med Chem; 2007 Oct; 42(10):1247-62. PubMed ID: 17420073
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of bicyclic sigma receptor ligands with cytotoxic activity.
    Geiger C; Zelenka C; Weigl M; Fröhlich R; Wibbeling B; Lehmkuhl K; Schepmann D; Grünert R; Bednarski PJ; Wünsch B
    J Med Chem; 2007 Nov; 50(24):6144-53. PubMed ID: 17967001
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
    Berardi F; Abate C; Ferorelli S; Uricchio V; Colabufo NA; Niso M; Perrone R
    J Med Chem; 2009 Dec; 52(23):7817-28. PubMed ID: 19842660
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chiral, nonracemic (piperazin-2-yl)methanol derivatives with sigma-receptor affinity.
    Bedürftig S; Wünsch B
    Bioorg Med Chem; 2004 Jun; 12(12):3299-311. PubMed ID: 15158798
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.
    Berardi F; Ferorelli S; Abate C; Colabufo NA; Contino M; Perrone R; Tortorella V
    J Med Chem; 2004 Apr; 47(9):2308-17. PubMed ID: 15084129
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.
    Schläger T; Schepmann D; Würthwein EU; Wünsch B
    Bioorg Med Chem; 2008 Mar; 16(6):2992-3001. PubMed ID: 18221879
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity.
    Bedürftig S; Wünsch B
    Eur J Med Chem; 2009 Feb; 44(2):519-25. PubMed ID: 18499305
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and in vitro Evaluation of Novel Indole-Based Sigma Receptors Ligands.
    Yarim M; Koksal M; Schepmann D; Wünsch B
    Chem Biol Drug Des; 2011 Nov; 78(5):869-75. PubMed ID: 21848665
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.
    Geiger C; Zelenka C; Lehmkuhl K; Schepmann D; Englberger W; Wünsch B
    J Med Chem; 2010 May; 53(10):4212-22. PubMed ID: 20441176
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bicyclic sigma receptor ligands by stereoselective Dieckmann analogous cyclization of piperazinebutyrate.
    Sunnam SK; Schepmann D; Wibbeling B; Wünsch B
    Org Biomol Chem; 2010 Aug; 8(16):3715-22. PubMed ID: 20556273
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rigidity versus Flexibility: Is This an Issue in σ1 Receptor Ligand Affinity and Activity?
    Weber F; Brune S; Börgel F; Lange C; Korpis K; Bednarski PJ; Laurini E; Fermeglia M; Pricl S; Schepmann D; Wünsch B
    J Med Chem; 2016 Jun; 59(11):5505-19. PubMed ID: 27156565
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.
    Abate C; Niso M; Lacivita E; Mosier PD; Toscano A; Perrone R
    J Med Chem; 2011 Feb; 54(4):1022-32. PubMed ID: 21229979
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
    Costantino L; Gandolfi F; Sorbi C; Franchini S; Prezzavento O; Vittorio F; Ronsisvalle G; Leonardi A; Poggesi E; Brasili L
    J Med Chem; 2005 Jan; 48(1):266-73. PubMed ID: 15634021
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
    Berardi F; Abate C; Ferorelli S; de Robertis AF; Leopoldo M; Colabufo NA; Niso M; Perrone R
    J Med Chem; 2008 Dec; 51(23):7523-31. PubMed ID: 19053780
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-activity comparison of YZ-069, a novel sigma ligand, and four analogs in receptor binding and behavioral studies.
    Matsumoto RR; Potelleret FH; Mack A; Pouw B; Zhang Y; Bowen WD
    Pharmacol Biochem Behav; 2004 Apr; 77(4):775-81. PubMed ID: 15099923
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.