These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 19099398)

  • 1. Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
    Thompson AM; Blaser A; Anderson RF; Shinde SS; Franzblau SG; Ma Z; Denny WA; Palmer BD
    J Med Chem; 2009 Feb; 52(3):637-45. PubMed ID: 19099398
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
    Kmentova I; Sutherland HS; Palmer BD; Blaser A; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA; Thompson AM
    J Med Chem; 2010 Dec; 53(23):8421-39. PubMed ID: 21069962
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
    Palmer BD; Thompson AM; Sutherland HS; Blaser A; Kmentova I; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA
    J Med Chem; 2010 Jan; 53(1):282-94. PubMed ID: 19928920
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
    Kim P; Kang S; Boshoff HI; Jiricek J; Collins M; Singh R; Manjunatha UH; Niyomrattanakit P; Zhang L; Goodwin M; Dick T; Keller TH; Dowd CS; Barry CE
    J Med Chem; 2009 Mar; 52(5):1329-44. PubMed ID: 19209893
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.
    Kim P; Zhang L; Manjunatha UH; Singh R; Patel S; Jiricek J; Keller TH; Boshoff HI; Barry CE; Dowd CS
    J Med Chem; 2009 Mar; 52(5):1317-28. PubMed ID: 19209889
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
    Li X; Manjunatha UH; Goodwin MB; Knox JE; Lipinski CA; Keller TH; Barry CE; Dowd CS
    Bioorg Med Chem Lett; 2008 Apr; 18(7):2256-62. PubMed ID: 18358721
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
    Blaser A; Palmer BD; Sutherland HS; Kmentova I; Franzblau SG; Wan B; Wang Y; Ma Z; Thompson AM; Denny WA
    J Med Chem; 2012 Jan; 55(1):312-26. PubMed ID: 22148391
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
    Palmer BD; Sutherland HS; Blaser A; Kmentova I; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA; Thompson AM
    J Med Chem; 2015 Apr; 58(7):3036-59. PubMed ID: 25781074
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine (PA-824).
    Thompson AM; Sutherland HS; Palmer BD; Kmentova I; Blaser A; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA
    J Med Chem; 2011 Oct; 54(19):6563-85. PubMed ID: 21846109
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution.
    Anderson RF; Shinde SS; Maroz A; Boyd M; Palmer BD; Denny WA
    Org Biomol Chem; 2008 Jun; 6(11):1973-80. PubMed ID: 18480913
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, structure and biological evaluation of novel bicyclic nitroimidazole derivatives.
    Zaprutko L; Zwawiak J; Augustynowicz-Kopeć E; Zwolska Z; Bartoszak-Adamska E; Nowicki W
    Arch Pharm (Weinheim); 2012 Jun; 345(6):463-7. PubMed ID: 22266946
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and anti-tubercular activity of 2-nitroimidazooxazines with modification at the C-7 position as PA-824 analogs.
    Kang YG; Park CY; Shin H; Singh R; Arora G; Yu CM; Lee IY
    Bioorg Med Chem Lett; 2015 Sep; 25(17):3650-3. PubMed ID: 26199118
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 3D QSAR, Docking, Molecular Dynamics Simulations and MM-GBSA studies of Extended Side Chain of the Antitubercular Drug (6S) 2-Nitro-6- {[4-(trifluoromethoxy) benzyl] oxy}-6,7-dihydro-5H-imidazo[2,1-b] [1,3] oxazine.
    Chaudhari HK; Pahelkar A
    Infect Disord Drug Targets; 2019; 19(2):145-166. PubMed ID: 30324898
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824.
    Bollo S; Núñez-Vergara LJ; Kang S; Zhang L; Boshoff HI; Barry CE; Squella JA; Dowd CS
    Bioorg Med Chem Lett; 2011 Jan; 21(2):812-7. PubMed ID: 21168331
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).
    Cherian J; Choi I; Nayyar A; Manjunatha UH; Mukherjee T; Lee YS; Boshoff HI; Singh R; Ha YH; Goodwin M; Lakshminarayana SB; Niyomrattanakit P; Jiricek J; Ravindran S; Dick T; Keller TH; Dartois V; Barry CE
    J Med Chem; 2011 Aug; 54(16):5639-59. PubMed ID: 21755942
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, in vitro-antimycobacterial activity and cytotoxicity of some alkyl alpha-(5-aryl-1, 3, 4-thiadiazole-2-ylthio)acetates.
    Foroumadi A; Soltani F; Moallemzadeh-Haghighi H; Shafiee A
    Arch Pharm (Weinheim); 2005 Mar; 338(2-3):112-6. PubMed ID: 15756694
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacophore modeling and density functional theory analysis for a series of nitroimidazole compounds with antitubercular activity.
    Tawari NR; Degani MS
    Chem Biol Drug Des; 2011 Sep; 78(3):408-17. PubMed ID: 21689377
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and antitubercular activity of monocyclic nitroimidazoles: insights from econazole.
    Lee SH; Kim S; Yun MH; Lee YS; Cho SN; Oh T; Kim P
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1515-8. PubMed ID: 21277200
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.
    Manjunatha UH; Boshoff H; Dowd CS; Zhang L; Albert TJ; Norton JE; Daniels L; Dick T; Pang SS; Barry CE
    Proc Natl Acad Sci U S A; 2006 Jan; 103(2):431-6. PubMed ID: 16387854
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and anti-tuberculosis activity of N-aryl-C-nitroazoles.
    Walczak K; Gondela A; Suwiński J
    Eur J Med Chem; 2004 Oct; 39(10):849-53. PubMed ID: 15464618
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.