BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 19105722)

  • 1. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion.
    Yue W; Abe K; Brouwer KL
    Mol Pharm; 2009; 6(1):134-43. PubMed ID: 19105722
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.
    Yang K; Pfeifer ND; Hardwick RN; Yue W; Stewart PW; Brouwer KL
    Mol Pharm; 2014 Mar; 11(3):766-75. PubMed ID: 24410402
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats.
    Yue W; Lee JK; Abe K; Sugiyama Y; Brouwer KL
    Drug Metab Dispos; 2011 Mar; 39(3):441-7. PubMed ID: 21106720
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.
    Yang K; Brouwer KL
    Drug Metab Dispos; 2014 Jul; 42(7):1219-26. PubMed ID: 24799397
    [TBL] [Abstract][Full Text] [Related]  

  • 5. [Evaluation of P-glycoprotein mediated in vitro loperamide biliary excretion with sandwich-cultured rat hepatocytes model].
    Shen GL; Zhuang XM; Yuan M; Sun HX; Li H
    Yao Xue Xue Bao; 2012 Apr; 47(4):459-65. PubMed ID: 22799027
    [TBL] [Abstract][Full Text] [Related]  

  • 6. P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.
    Annaert PP; Turncliff RZ; Booth CL; Thakker DR; Brouwer KL
    Drug Metab Dispos; 2001 Oct; 29(10):1277-83. PubMed ID: 11560870
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes.
    Swift B; Yue W; Brouwer KL
    Pharm Res; 2010 Sep; 27(9):1987-98. PubMed ID: 20652625
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity.
    Lee JK; Leslie EM; Zamek-Gliszczynski MJ; Brouwer KL
    Toxicol Appl Pharmacol; 2008 Apr; 228(1):17-23. PubMed ID: 18191164
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.
    Abe K; Bridges AS; Yue W; Brouwer KL
    J Pharmacol Exp Ther; 2008 Sep; 326(3):983-90. PubMed ID: 18574002
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.
    Tian X; Li J; Zamek-Gliszczynski MJ; Bridges AS; Zhang P; Patel NJ; Raub TJ; Pollack GM; Brouwer KL
    Antimicrob Agents Chemother; 2007 Sep; 51(9):3230-4. PubMed ID: 17576841
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.
    Zamek-Gliszczynski MJ; Hoffmaster KA; Tian X; Zhao R; Polli JW; Humphreys JE; Webster LO; Bridges AS; Kalvass JC; Brouwer KL
    Drug Metab Dispos; 2005 Aug; 33(8):1158-65. PubMed ID: 15860656
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.
    Li N; Bi YA; Duignan DB; Lai Y
    Mol Pharm; 2009; 6(4):1180-9. PubMed ID: 19545175
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters.
    Li N; Singh P; Mandrell KM; Lai Y
    Mol Pharm; 2010 Jun; 7(3):630-41. PubMed ID: 20438085
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds.
    Farasyn T; Xu C; Yue W
    J Pharm Pharm Sci; 2021; 24():475-483. PubMed ID: 34516949
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.
    Jonker JW; Smit JW; Brinkhuis RF; Maliepaard M; Beijnen JH; Schellens JH; Schinkel AH
    J Natl Cancer Inst; 2000 Oct; 92(20):1651-6. PubMed ID: 11036110
    [TBL] [Abstract][Full Text] [Related]  

  • 16. N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918) as a chemical ATP-binding cassette transporter family G member 2 (Abcg2) knockout model to study nitrofurantoin transfer into milk.
    Wang L; Leggas M; Goswami M; Empey PE; McNamara PJ
    Drug Metab Dispos; 2008 Dec; 36(12):2591-6. PubMed ID: 18799806
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A new intestinal cell culture model to discriminate the relative contribution of P-gp and BCRP on transport of substrates such as imatinib.
    Graber-Maier A; Gutmann H; Drewe J
    Mol Pharm; 2010 Oct; 7(5):1618-28. PubMed ID: 20701289
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes.
    Fukuda H; Ohashi R; Tsuda-Tsukimoto M; Tamai I
    Drug Metab Dispos; 2008 Jul; 36(7):1275-82. PubMed ID: 18388177
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Deletion of Abcg2 has differential effects on excretion and pharmacokinetics of probe substrates in rats.
    Huang L; Be X; Tchaparian EH; Colletti AE; Roberts J; Langley M; Ling Y; Wong BK; Jin L
    J Pharmacol Exp Ther; 2012 Nov; 343(2):316-24. PubMed ID: 22869929
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.
    Oostendorp RL; Buckle T; Beijnen JH; van Tellingen O; Schellens JH
    Invest New Drugs; 2009 Feb; 27(1):31-40. PubMed ID: 18449471
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.