217 related articles for article (PubMed ID: 19117394)
1. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
Junnotula V; Sarkar U; Sinha S; Gates KS
J Am Chem Soc; 2009 Jan; 131(3):1015-24. PubMed ID: 19117394
[TBL] [Abstract][Full Text] [Related]
2. Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
Shinde SS; Anderson RF; Hay MP; Gamage SA; Denny WA
J Am Chem Soc; 2004 Jun; 126(25):7865-74. PubMed ID: 15212534
[TBL] [Abstract][Full Text] [Related]
3. Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.
Shen X; Rajapakse A; Gallazzi F; Junnotula V; Fuchs-Knotts T; Glaser R; Gates KS
Chem Res Toxicol; 2014 Jan; 27(1):111-8. PubMed ID: 24328261
[TBL] [Abstract][Full Text] [Related]
4. DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).
Chowdhury G; Junnotula V; Daniels JS; Greenberg MM; Gates KS
J Am Chem Soc; 2007 Oct; 129(42):12870-7. PubMed ID: 17900117
[TBL] [Abstract][Full Text] [Related]
5. Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine.
Anderson RF; Harris TA; Hay MP; Denny WA
Chem Res Toxicol; 2003 Nov; 16(11):1477-83. PubMed ID: 14615975
[TBL] [Abstract][Full Text] [Related]
6. Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
Anderson RF; Shinde SS; Hay MP; Gamage SA; Denny WA
Org Biomol Chem; 2005 Jun; 3(11):2167-74. PubMed ID: 15917906
[TBL] [Abstract][Full Text] [Related]
7. Photochemical and photobiological studies of tirapazamine (SR 4233) and related quinoxaline 1,4-Di-N-oxide analogues.
Inbaraj JJ; Motten AG; Chignell CF
Chem Res Toxicol; 2003 Feb; 16(2):164-70. PubMed ID: 12588187
[TBL] [Abstract][Full Text] [Related]
8. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction.
Anderson RF; Shinde SS; Hay MP; Gamage SA; Denny WA
J Am Chem Soc; 2003 Jan; 125(3):748-56. PubMed ID: 12526674
[TBL] [Abstract][Full Text] [Related]
9. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
Anderson RF; Shinde SS; Hay MP; Denny WA
J Am Chem Soc; 2006 Jan; 128(1):245-9. PubMed ID: 16390153
[TBL] [Abstract][Full Text] [Related]
10. Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs).
Elsaidi HR; Yang XH; Ahmadi F; Weinfeld M; Wiebe LI; Kumar P
Eur J Med Chem; 2019 Mar; 165():216-224. PubMed ID: 30684798
[TBL] [Abstract][Full Text] [Related]
11. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
Hwang JT; Greenberg MM; Fuchs T; Gates KS
Biochemistry; 1999 Oct; 38(43):14248-55. PubMed ID: 10571998
[TBL] [Abstract][Full Text] [Related]
12. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Fuchs T; Chowdhury G; Barnes CL; Gates KS
J Org Chem; 2001 Jan; 66(1):107-14. PubMed ID: 11429885
[TBL] [Abstract][Full Text] [Related]
13. Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells.
Moriwaki T; Okamoto S; Sasanuma H; Nagasawa H; Takeda S; Masunaga SI; Tano K
Chem Res Toxicol; 2017 Feb; 30(2):699-704. PubMed ID: 27943678
[TBL] [Abstract][Full Text] [Related]
14. Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides.
Qi W; Yadav P; Hong CR; Stevenson RJ; Hay MP; Anderson RF
Molecules; 2022 Jan; 27(3):. PubMed ID: 35164077
[TBL] [Abstract][Full Text] [Related]
15. Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase.
Shinde SS; Hay MP; Patterson AV; Denny WA; Anderson RF
J Am Chem Soc; 2009 Oct; 131(40):14220-1. PubMed ID: 19772319
[TBL] [Abstract][Full Text] [Related]
16. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Johnson KM; Parsons ZD; Barnes CL; Gates KS
J Org Chem; 2014 Aug; 79(16):7520-31. PubMed ID: 25029663
[TBL] [Abstract][Full Text] [Related]
17. Tirapazamine: laboratory data relevant to clinical activity.
Brown JM; Wang LH
Anticancer Drug Des; 1998 Sep; 13(6):529-39. PubMed ID: 9755717
[TBL] [Abstract][Full Text] [Related]
18. Metabolism of tirapazamine by multiple reductases in the nucleus.
Delahoussaye YM; Evans JW; Brown JM
Biochem Pharmacol; 2001 Nov; 62(9):1201-9. PubMed ID: 11705453
[TBL] [Abstract][Full Text] [Related]
19. DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.
Junnotula V; Rajapakse A; Arbillaga L; de Cerain AL; Solano B; Villar R; Monge A; Gates KS
Bioorg Med Chem; 2010 May; 18(9):3125-32. PubMed ID: 20371184
[TBL] [Abstract][Full Text] [Related]
20. DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Birincioglu M; Jaruga P; Chowdhury G; Rodriguez H; Dizdaroglu M; Gates KS
J Am Chem Soc; 2003 Sep; 125(38):11607-15. PubMed ID: 13129365
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]