These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 19120695)

  • 1. Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization.
    Chang YP; Mahadeva R; Chang WW; Lin SC; Chu YH
    J Cell Mol Med; 2009 Aug; 13(8B):2304-2316. PubMed ID: 19120695
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z alpha1-antitrypsin.
    Chang YP; Mahadeva R; Chang WS; Shukla A; Dafforn TR; Chu YH
    Am J Respir Cell Mol Biol; 2006 Nov; 35(5):540-8. PubMed ID: 16778151
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular Mechanism of Z α1-Antitrypsin Deficiency.
    Huang X; Zheng Y; Zhang F; Wei Z; Wang Y; Carrell RW; Read RJ; Chen GQ; Zhou A
    J Biol Chem; 2016 Jul; 291(30):15674-86. PubMed ID: 27246852
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema.
    Parfrey H; Dafforn TR; Belorgey D; Lomas DA; Mahadeva R
    Am J Respir Cell Mol Biol; 2004 Aug; 31(2):133-9. PubMed ID: 15016619
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prevention of polymerization of M and Z alpha1-Antitrypsin (alpha1-AT) with trimethylamine N-oxide. Implications for the treatment of alpha1-at deficiency.
    Devlin GL; Parfrey H; Tew DJ; Lomas DA; Bottomley SP
    Am J Respir Cell Mol Biol; 2001 Jun; 24(6):727-32. PubMed ID: 11415938
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.
    Mallya M; Phillips RL; Saldanha SA; Gooptu B; Brown SC; Termine DJ; Shirvani AM; Wu Y; Sifers RN; Abagyan R; Lomas DA
    J Med Chem; 2007 Nov; 50(22):5357-63. PubMed ID: 17918823
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.
    Mahadeva R; Dafforn TR; Carrell RW; Lomas DA
    J Biol Chem; 2002 Mar; 277(9):6771-4. PubMed ID: 11773044
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Preventing and reversing the cellular consequences of Z alpha-1 antitrypsin accumulation by targeting s4A.
    Alam S; Wang J; Janciauskiene S; Mahadeva R
    J Hepatol; 2012 Jul; 57(1):116-24. PubMed ID: 22425623
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis.
    Mahadeva R; Chang WS; Dafforn TR; Oakley DJ; Foreman RC; Calvin J; Wight DG; Lomas DA
    J Clin Invest; 1999 Apr; 103(7):999-1006. PubMed ID: 10194472
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.
    Nyon MP; Prentice T; Day J; Kirkpatrick J; Sivalingam GN; Levy G; Haq I; Irving JA; Lomas DA; Christodoulou J; Gooptu B; Thalassinos K
    Protein Sci; 2015 Aug; 24(8):1301-12. PubMed ID: 26011795
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema.
    Elliott PR; Bilton D; Lomas DA
    Am J Respir Cell Mol Biol; 1998 May; 18(5):670-4. PubMed ID: 9569237
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The mechanism of alpha 1-antitrypsin polymerization probed by fluorescence spectroscopy.
    James EL; Bottomley SP
    Arch Biochem Biophys; 1998 Aug; 356(2):296-300. PubMed ID: 9705220
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization.
    Berthelier V; Harris JB; Estenson KN; Baudry J
    PLoS One; 2015; 10(5):e0126256. PubMed ID: 25961288
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.
    Ordóñez A; Pérez J; Tan L; Dickens JA; Motamedi-Shad N; Irving JA; Haq I; Ekeowa U; Marciniak SJ; Miranda E; Lomas DA
    FASEB J; 2015 Jun; 29(6):2667-78. PubMed ID: 25757566
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The shapes of Z-α1-antitrypsin polymers in solution support the C-terminal domain-swap mechanism of polymerization.
    Behrens MA; Sendall TJ; Pedersen JS; Kjeldgaard M; Huntington JA; Jensen JK
    Biophys J; 2014 Oct; 107(8):1905-1912. PubMed ID: 25418171
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Loop-sheet polymerization: the structural basis of Z alpha 1-antitrypsin accumulation in the liver.
    Lomas DA
    Clin Sci (Lond); 1994 May; 86(5):489-95. PubMed ID: 8033502
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Loop-sheet polymerization: the mechanism of alpha1-antitrypsin deficiency.
    Lomas DA
    Respir Med; 2000 Aug; 94 Suppl C():S3-6. PubMed ID: 10954247
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Z type variation of human alpha 1-antitrypsin causes a protein folding defect.
    Yu MH; Lee KN; Kim J
    Nat Struct Biol; 1995 May; 2(5):363-7. PubMed ID: 7664092
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.
    Knaupp AS; Levina V; Robertson AL; Pearce MC; Bottomley SP
    J Mol Biol; 2010 Feb; 396(2):375-83. PubMed ID: 19944704
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cleaved antitrypsin polymers at atomic resolution.
    Dunstone MA; Dai W; Whisstock JC; Rossjohn J; Pike RN; Feil SC; Le Bonniec BF; Parker MW; Bottomley SP
    Protein Sci; 2000 Feb; 9(2):417-20. PubMed ID: 10716194
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.