146 related articles for article (PubMed ID: 19138149)
1. Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.
Sun W; Nikolovska-Coleska Z; Qin D; Sun H; Yang CY; Bai L; Qiu S; Wang Y; Ma D; Wang S
J Med Chem; 2009 Feb; 52(3):593-6. PubMed ID: 19138149
[TBL] [Abstract][Full Text] [Related]
2. Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
Sun H; Lu J; Liu L; Yi H; Qiu S; Yang CY; Deschamps JR; Wang S
J Med Chem; 2010 Sep; 53(17):6361-7. PubMed ID: 20684551
[TBL] [Abstract][Full Text] [Related]
3. Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases.
Peng Y; Sun H; Nikolovska-Coleska Z; Qiu S; Yang CY; Lu J; Cai Q; Yi H; Kang S; Yang D; Wang S
J Med Chem; 2008 Dec; 51(24):8158-62. PubMed ID: 19049347
[TBL] [Abstract][Full Text] [Related]
4. Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.
Nikolovska-Coleska Z; Meagher JL; Jiang S; Kawamoto SA; Gao W; Yi H; Qin D; Roller PP; Stuckey JA; Wang S
Anal Biochem; 2008 Mar; 374(1):87-98. PubMed ID: 18023397
[TBL] [Abstract][Full Text] [Related]
5. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.
Bockbrader KM; Tan M; Sun Y
Oncogene; 2005 Nov; 24(49):7381-8. PubMed ID: 16044155
[TBL] [Abstract][Full Text] [Related]
6. Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.
Sun H; Lu J; Liu L; Yang CY; Wang S
ACS Chem Biol; 2014 Apr; 9(4):994-1002. PubMed ID: 24521431
[TBL] [Abstract][Full Text] [Related]
7. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.
Sun H; Liu L; Lu J; Bai L; Li X; Nikolovska-Coleska Z; McEachern D; Yang CY; Qiu S; Yi H; Sun D; Wang S
J Med Chem; 2011 May; 54(9):3306-18. PubMed ID: 21462933
[TBL] [Abstract][Full Text] [Related]
8. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.
Lu J; Bai L; Sun H; Nikolovska-Coleska Z; McEachern D; Qiu S; Miller RS; Yi H; Shangary S; Sun Y; Meagher JL; Stuckey JA; Wang S
Cancer Res; 2008 Nov; 68(22):9384-93. PubMed ID: 19010913
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases.
Zhang B; Nikolovska-Coleska Z; Zhang Y; Bai L; Qiu S; Yang CY; Sun H; Wang S; Wu Y
J Med Chem; 2008 Dec; 51(23):7352-5. PubMed ID: 19012392
[TBL] [Abstract][Full Text] [Related]
10. Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells.
Zhang S; Li G; Zhao Y; Liu G; Wang Y; Ma X; Li D; Wu Y; Lu J
PLoS One; 2012; 7(12):e51461. PubMed ID: 23240027
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
Sun H; Nikolovska-Coleska Z; Lu J; Meagher JL; Yang CY; Qiu S; Tomita Y; Ueda Y; Jiang S; Krajewski K; Roller PP; Stuckey JA; Wang S
J Am Chem Soc; 2007 Dec; 129(49):15279-94. PubMed ID: 17999504
[TBL] [Abstract][Full Text] [Related]
12. Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.
Cossu F; Milani M; Mastrangelo E; Vachette P; Servida F; Lecis D; Canevari G; Delia D; Drago C; Rizzo V; Manzoni L; Seneci P; Scolastico C; Bolognesi M
J Mol Biol; 2009 Sep; 392(3):630-44. PubMed ID: 19393243
[TBL] [Abstract][Full Text] [Related]
13. Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma.
Wu MS; Wang GF; Zhao ZQ; Liang Y; Wang HB; Wu MY; Min P; Chen LZ; Feng QS; Bei JX; Zeng YX; Yang D
Mol Cancer Ther; 2013 Sep; 12(9):1728-37. PubMed ID: 23699656
[TBL] [Abstract][Full Text] [Related]
14. Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: identification of potent XIAP BIR3 antagonists.
Elsawy MA; Martin L; Tikhonova IG; Walker B
Bioorg Med Chem; 2013 Sep; 21(17):5004-11. PubMed ID: 23886811
[TBL] [Abstract][Full Text] [Related]
15. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
Allensworth JL; Sauer SJ; Lyerly HK; Morse MA; Devi GR
Breast Cancer Res Treat; 2013 Jan; 137(2):359-71. PubMed ID: 23225169
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Zobel K; Wang L; Varfolomeev E; Franklin MC; Elliott LO; Wallweber HJ; Okawa DC; Flygare JA; Vucic D; Fairbrother WJ; Deshayes K
ACS Chem Biol; 2006 Sep; 1(8):525-33. PubMed ID: 17168540
[TBL] [Abstract][Full Text] [Related]
17. Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
Corti A; Milani M; Lecis D; Seneci P; de Rosa M; Mastrangelo E; Cossu F
FEBS J; 2018 Sep; 285(17):3286-3298. PubMed ID: 30055105
[TBL] [Abstract][Full Text] [Related]
18. Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
Kester RF; Donnell AF; Lou Y; Remiszewski SW; Lombardo LJ; Chen S; Le NT; Lo J; Moliterni JA; Han X; Hogg JH; Liang W; Michoud C; Rupert KC; Mischke S; Le K; Weisel M; Janson CA; Lukacs CM; Fretland AJ; Hong K; Polonskaia A; Gao L; Li S; Solis DS; Aguilar D; Tardell C; Dvorozniak M; Tannu S; Lee EC; Schutt AD; Goggin B
J Med Chem; 2013 Oct; 56(20):7788-803. PubMed ID: 24093940
[TBL] [Abstract][Full Text] [Related]
19. Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.
Nikolovska-Coleska Z; Meagher JL; Jiang S; Yang CY; Qiu S; Roller PP; Stuckey JA; Wang S
Biochemistry; 2008 Sep; 47(37):9811-24. PubMed ID: 18717598
[TBL] [Abstract][Full Text] [Related]
20. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
Welsh K; Milutinovic S; Ardecky RJ; Gonzalez-Lopez M; Ganji SR; Teriete P; Finlay D; Riedl S; Matsuzawa S; Pinilla C; Houghten R; Vuori K; Reed JC; Cosford ND
PLoS One; 2016; 11(9):e0161952. PubMed ID: 27617834
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]