123 related articles for article (PubMed ID: 19147350)
21. Design, synthesis, and structure-activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine.
Yoshizumi T; Miyazoe H; Ito H; Tsujita T; Takahashi H; Asai M; Ozaki S; Ohta H; Okamoto O
Bioorg Med Chem Lett; 2008 Jul; 18(13):3778-82. PubMed ID: 18515099
[TBL] [Abstract][Full Text] [Related]
22. Structure-activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough.
Yang SW; Ho G; Tulshian D; Greenlee WJ; Fernandez X; McLeod RL; Eckel S; Anthes J
Bioorg Med Chem Lett; 2008 Dec; 18(24):6340-3. PubMed ID: 18990569
[TBL] [Abstract][Full Text] [Related]
23. Spiro-substituted piperidines as neurokinin receptor antagonists. III. Synthesis of (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and evaluation of NK1-NK2 dual antagonistic activities.
Kubota H; Kakefuda A; Okamoto Y; Fujii M; Yamamoto O; Yamagiwa Y; Orita M; Ikeda K; Takeuchi M; Shibanuma T; Isomura Y
Chem Pharm Bull (Tokyo); 1998 Oct; 46(10):1538-44. PubMed ID: 9810691
[TBL] [Abstract][Full Text] [Related]
24. Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.
Jasper A; Schepmann D; Lehmkuhl K; Vela JM; Buschmann H; Holenz J; Wünsch B
Eur J Med Chem; 2009 Nov; 44(11):4306-14. PubMed ID: 19709783
[TBL] [Abstract][Full Text] [Related]
25. New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists.
Smith PW; Cooper AW; Bell R; Beresford IJ; Gore PM; McElroy AB; Pritchard JM; Saez V; Taylor NR; Sheldrick RL
J Med Chem; 1995 Sep; 38(19):3772-9. PubMed ID: 7562907
[TBL] [Abstract][Full Text] [Related]
26. Structure-antigastrin activity relationships of new spiroglumide amido acid derivatives.
Makovec F; Peris W; Frigerio S; Giovanetti R; Letari O; Mennuni L; Revel L
J Med Chem; 1996 Jan; 39(1):135-42. PubMed ID: 8568800
[TBL] [Abstract][Full Text] [Related]
27. High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Röver S; Adam G; Cesura AM; Galley G; Jenck F; Monsma FJ; Wichmann J; Dautzenberg FM
J Med Chem; 2000 Apr; 43(7):1329-38. PubMed ID: 10753470
[TBL] [Abstract][Full Text] [Related]
28. Discovery of novel SCD1 inhibitors: 5-alkyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] analogs.
Uto Y; Ueno Y; Kiyotsuka Y; Miyazawa Y; Kurata H; Ogata T; Takagi T; Wakimoto S; Ohsumi J
Eur J Med Chem; 2011 May; 46(5):1892-6. PubMed ID: 21356569
[TBL] [Abstract][Full Text] [Related]
29. Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors.
Pinard E; Ceccarelli SM; Stalder H; Alberati D
Bioorg Med Chem Lett; 2006 Jan; 16(2):349-53. PubMed ID: 16246557
[TBL] [Abstract][Full Text] [Related]
30. From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.
Guba W; Green LG; Martin RE; Roche O; Kratochwil N; Mauser H; Bissantz C; Christ A; Stahl M
J Med Chem; 2007 Dec; 50(25):6295-8. PubMed ID: 18020391
[TBL] [Abstract][Full Text] [Related]
31. 1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (Compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices.
Liao YY; Trapella C; Chiou LC
Eur J Pharmacol; 2009 Mar; 606(1-3):84-9. PubMed ID: 19374842
[TBL] [Abstract][Full Text] [Related]
32. Spiro-substituted piperidines as neurokinin receptor antagonists. I. Design and synthesis of (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro [isobenzofuran-1(3H),4'piperidin]-1'-yl)butyl]-N-methylbenzamide, YM-35375, as a new lead compound for novel neurokinin receptor antagonists.
Kubota H; Fujii M; Ikeda K; Takeuchi M; Shibanuma T; Isomura Y
Chem Pharm Bull (Tokyo); 1998 Feb; 46(2):351-4. PubMed ID: 9501470
[TBL] [Abstract][Full Text] [Related]
33. Synthesis and evaluation as NOP ligands of some spiro[piperidine-4,2'(1'H)-quinazolin]-4'(3'H)-ones and spiro[piperidine-4,5'(6'H)-[1,2,4]triazolo[1,5-c]quinazolines].
Mustazza C; Borioni A; Sestili I; Sbraccia M; Rodomonte A; Ferretti R; Del Giudice MR
Chem Pharm Bull (Tokyo); 2006 May; 54(5):611-22. PubMed ID: 16651754
[TBL] [Abstract][Full Text] [Related]
34. Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists.
Meyer ME; Doshi A; Yasuda D; Zaveri NT
AAPS J; 2021 May; 23(3):68. PubMed ID: 33974173
[TBL] [Abstract][Full Text] [Related]
35. Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
Takahashi T; Haga Y; Sakamoto T; Moriya M; Okamoto O; Nonoshita K; Shibata T; Suga T; Takahashi H; Hirohashi T; Sakuraba A; Gomori A; Iwaasa H; Ohe T; Ishihara A; Ishii Y; Kanatani A; Fukami T
Bioorg Med Chem Lett; 2009 Jul; 19(13):3511-6. PubMed ID: 19464889
[TBL] [Abstract][Full Text] [Related]
36. Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Journigan VB; Polgar WE; Khroyan TV; Zaveri NT
Bioorg Med Chem; 2014 Apr; 22(8):2508-16. PubMed ID: 24657054
[TBL] [Abstract][Full Text] [Related]
37. A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor.
Zaveri NT; Jiang F; Olsen CM; Deschamps JR; Parrish D; Polgar W; Toll L
J Med Chem; 2004 Jun; 47(12):2973-6. PubMed ID: 15163178
[TBL] [Abstract][Full Text] [Related]
38. Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.
Chang SD; Mascarella SW; Spangler SM; Gurevich VV; Navarro HA; Carroll FI; Bruchas MR
Mol Pharmacol; 2015 Sep; 88(3):502-11. PubMed ID: 26134494
[TBL] [Abstract][Full Text] [Related]
39. Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity.
Oberdorf C; Schepmann D; Vela JM; Buschmann H; Holenz J; Wünsch B
J Med Chem; 2012 Jun; 55(11):5350-60. PubMed ID: 22515405
[TBL] [Abstract][Full Text] [Related]
40. 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.
Bignan GC; Battista K; Connolly PJ; Orsini MJ; Liu J; Middleton SA; Reitz AB
Bioorg Med Chem Lett; 2006 Jul; 16(13):3524-8. PubMed ID: 16632355
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
