BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

228 related articles for article (PubMed ID: 19148767)

  • 1. Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators.
    Reynolds KA; Katritch V; Abagyan R
    J Comput Aided Mol Des; 2009 May; 23(5):273-88. PubMed ID: 19148767
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-Based Prediction of G-Protein-Coupled Receptor Ligand Function: A β-Adrenoceptor Case Study.
    Kooistra AJ; Leurs R; de Esch IJ; de Graaf C
    J Chem Inf Model; 2015 May; 55(5):1045-61. PubMed ID: 25848966
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.
    West GM; Chien EY; Katritch V; Gatchalian J; Chalmers MJ; Stevens RC; Griffin PR
    Structure; 2011 Oct; 19(10):1424-32. PubMed ID: 21889352
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes.
    Katritch V; Reynolds KA; Cherezov V; Hanson MA; Roth CB; Yeager M; Abagyan R
    J Mol Recognit; 2009; 22(4):307-18. PubMed ID: 19353579
    [TBL] [Abstract][Full Text] [Related]  

  • 5. FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A.
    Michino M; Chen J; Stevens RC; Brooks CL
    Proteins; 2010 Aug; 78(10):2189-201. PubMed ID: 20544957
    [TBL] [Abstract][Full Text] [Related]  

  • 6. On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.
    Costanzi S
    J Med Chem; 2008 May; 51(10):2907-14. PubMed ID: 18442228
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure and function of an irreversible agonist-β(2) adrenoceptor complex.
    Rosenbaum DM; Zhang C; Lyons JA; Holl R; Aragao D; Arlow DH; Rasmussen SG; Choi HJ; Devree BT; Sunahara RK; Chae PS; Gellman SH; Dror RO; Shaw DE; Weis WI; Caffrey M; Gmeiner P; Kobilka BK
    Nature; 2011 Jan; 469(7329):236-40. PubMed ID: 21228876
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor.
    Goetz A; Lanig H; Gmeiner P; Clark T
    J Mol Biol; 2011 Dec; 414(4):611-23. PubMed ID: 22037586
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The dynamic process of β(2)-adrenergic receptor activation.
    Nygaard R; Zou Y; Dror RO; Mildorf TJ; Arlow DH; Manglik A; Pan AC; Liu CW; Fung JJ; Bokoch MP; Thian FS; Kobilka TS; Shaw DE; Mueller L; Prosser RS; Kobilka BK
    Cell; 2013 Jan; 152(3):532-42. PubMed ID: 23374348
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.
    Huber T; Menon S; Sakmar TP
    Biochemistry; 2008 Oct; 47(42):11013-23. PubMed ID: 18821775
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
    Bokoch MP; Zou Y; Rasmussen SG; Liu CW; Nygaard R; Rosenbaum DM; Fung JJ; Choi HJ; Thian FS; Kobilka TS; Puglisi JD; Weis WI; Pardo L; Prosser RS; Mueller L; Kobilka BK
    Nature; 2010 Jan; 463(7277):108-12. PubMed ID: 20054398
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptors.
    Bhattacharya S; Hall SE; Vaidehi N
    J Mol Biol; 2008 Oct; 382(2):539-55. PubMed ID: 18638482
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography.
    Wacker D; Fenalti G; Brown MA; Katritch V; Abagyan R; Cherezov V; Stevens RC
    J Am Chem Soc; 2010 Aug; 132(33):11443-5. PubMed ID: 20669948
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
    Rasmussen SG; Choi HJ; Fung JJ; Pardon E; Casarosa P; Chae PS; Devree BT; Rosenbaum DM; Thian FS; Kobilka TS; Schnapp A; Konetzki I; Sunahara RK; Gellman SH; Pautsch A; Steyaert J; Weis WI; Kobilka BK
    Nature; 2011 Jan; 469(7329):175-80. PubMed ID: 21228869
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes.
    Isin B; Estiu G; Wiest O; Oltvai ZN
    PLoS One; 2012; 7(12):e50186. PubMed ID: 23300522
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Efficacy of the β₂-adrenergic receptor is determined by conformational equilibrium in the transmembrane region.
    Kofuku Y; Ueda T; Okude J; Shiraishi Y; Kondo K; Maeda M; Tsujishita H; Shimada I
    Nat Commun; 2012; 3():1045. PubMed ID: 22948827
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening?
    Tang H; Wang XS; Hsieh JH; Tropsha A
    Proteins; 2012 Jun; 80(6):1503-21. PubMed ID: 22275072
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modeling GPCR active state conformations: the β(2)-adrenergic receptor.
    Simpson LM; Wall ID; Blaney FE; Reynolds CA
    Proteins; 2011 May; 79(5):1441-57. PubMed ID: 21337626
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?
    Bissantz C; Bernard P; Hibert M; Rognan D
    Proteins; 2003 Jan; 50(1):5-25. PubMed ID: 12471595
    [TBL] [Abstract][Full Text] [Related]  

  • 20. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
    Cherezov V; Rosenbaum DM; Hanson MA; Rasmussen SG; Thian FS; Kobilka TS; Choi HJ; Kuhn P; Weis WI; Kobilka BK; Stevens RC
    Science; 2007 Nov; 318(5854):1258-65. PubMed ID: 17962520
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.