151 related articles for article (PubMed ID: 19149479)
1. Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugs.
Cipolla L; Araújo AC; Airoldi C; Bini D
Anticancer Agents Med Chem; 2009 Jan; 9(1):1-31. PubMed ID: 19149479
[TBL] [Abstract][Full Text] [Related]
2. Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation.
Kumar R; Lown JW
Mini Rev Med Chem; 2003 Jun; 3(4):323-39. PubMed ID: 12678826
[TBL] [Abstract][Full Text] [Related]
3. The development of pyrrolobenzodiazepines as antitumour agents.
Hartley JA
Expert Opin Investig Drugs; 2011 Jun; 20(6):733-44. PubMed ID: 21457108
[TBL] [Abstract][Full Text] [Related]
4. Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo[2,1-c][1,4]benzodiazepines as DNA-interactive antitumour antibiotics.
Kamal A; Rao MV; Laxman N; Ramesh G; Reddy GS
Curr Med Chem Anticancer Agents; 2002 Mar; 2(2):215-54. PubMed ID: 12678745
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
Wilson SC; Howard PW; Forrow SM; Hartley JA; Adams LJ; Jenkins TC; Kelland LR; Thurston DE
J Med Chem; 1999 Oct; 42(20):4028-41. PubMed ID: 10514273
[TBL] [Abstract][Full Text] [Related]
6. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
[TBL] [Abstract][Full Text] [Related]
7. Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.
Rahman KM; James CH; Thurston DE
Nucleic Acids Res; 2011 Jul; 39(13):5800-12. PubMed ID: 21427082
[TBL] [Abstract][Full Text] [Related]
8. The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136.
Clingen PH; De Silva IU; McHugh PJ; Ghadessy FJ; Tilby MJ; Thurston DE; Hartley JA
Nucleic Acids Res; 2005; 33(10):3283-91. PubMed ID: 15944449
[TBL] [Abstract][Full Text] [Related]
9. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Hartley JA; Spanswick VJ; Brooks N; Clingen PH; McHugh PJ; Hochhauser D; Pedley RB; Kelland LR; Alley MC; Schultz R; Hollingshead MG; Schweikart KM; Tomaszewski JE; Sausville EA; Gregson SJ; Howard PW; Thurston DE
Cancer Res; 2004 Sep; 64(18):6693-9. PubMed ID: 15374986
[TBL] [Abstract][Full Text] [Related]
10. Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates.
Vlahov IR; Qi L; Kleindl PJ; Santhapuram HK; Felten A; Parham GL; Wang K; You F; Vaughn JF; Hahn SJ; Klein HF; Vetzel M; Reddy JA; Nelson M; Nicoson J; Leamon CP
Bioconjug Chem; 2017 Dec; 28(12):2921-2931. PubMed ID: 29211454
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.
Berry JM; Howard PW; Kelland LR; Thurston DE
Bioorg Med Chem Lett; 2002 May; 12(10):1413-6. PubMed ID: 11992788
[TBL] [Abstract][Full Text] [Related]
12. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.
Smellie M; Bose DS; Thompson AS; Jenkins TC; Hartley JA; Thurston DE
Biochemistry; 2003 Jul; 42(27):8232-9. PubMed ID: 12846572
[TBL] [Abstract][Full Text] [Related]
13. Pyrrolobenzodiazepine dimers: novel sequence-selective, DNA-interactive, cross-linking agents with activity against Gram-positive bacteria.
Hadjivassileva T; Thurston DE; Taylor PW
J Antimicrob Chemother; 2005 Sep; 56(3):513-8. PubMed ID: 16024592
[TBL] [Abstract][Full Text] [Related]
14. Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments.
Mantaj J; Jackson PJ; Karu K; Rahman KM; Thurston DE
PLoS One; 2016; 11(4):e0152303. PubMed ID: 27055050
[TBL] [Abstract][Full Text] [Related]
15. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
Mantaj J; Jackson PJ; Rahman KM; Thurston DE
Angew Chem Int Ed Engl; 2017 Jan; 56(2):462-488. PubMed ID: 27862776
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, DNA binding ability and anticancer activity of 2-heteroaryl substituted benzimidazoles linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
Kamal A; Pogula PK; Khan MN; Seshadri BN; Sreekanth K
Med Chem; 2013 Aug; 9(5):651-9. PubMed ID: 23301523
[TBL] [Abstract][Full Text] [Related]
17. Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition.
Jackson PJ; James CH; Jenkins TC; Rahman KM; Thurston DE
ACS Chem Biol; 2014 Oct; 9(10):2432-40. PubMed ID: 25111266
[TBL] [Abstract][Full Text] [Related]
18. Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: synthesis, DNA-binding affinity and cytotoxic activity.
Kamal A; Sreekanth K; Shankaraiah N; Sathish M; Nekkanti S; Srinivasulu V
Bioorg Chem; 2015 Apr; 59():23-30. PubMed ID: 25665519
[TBL] [Abstract][Full Text] [Related]
19. An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines.
Varvounis G
Molecules; 2016 Jan; 21(2):154. PubMed ID: 26828475
[TBL] [Abstract][Full Text] [Related]
20. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
Alley MC; Hollingshead MG; Pacula-Cox CM; Waud WR; Hartley JA; Howard PW; Gregson SJ; Thurston DE; Sausville EA
Cancer Res; 2004 Sep; 64(18):6700-6. PubMed ID: 15374987
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
