These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 19155174)

  • 1. Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
    Converso A; Hartingh T; Garbaccio RM; Tasber E; Rickert K; Fraley ME; Yan Y; Kreatsoulas C; Stirdivant S; Drakas B; Walsh ES; Hamilton K; Buser CA; Mao X; Abrams MT; Beck SC; Tao W; Lobell R; Sepp-Lorenzino L; Zugay-Murphy J; Sardana V; Munshi SK; Jezequel-Sur SM; Zuck PD; Hartman GD
    Bioorg Med Chem Lett; 2009 Feb; 19(4):1240-4. PubMed ID: 19155174
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening.
    Foloppe N; Fisher LM; Howes R; Potter A; Robertson AG; Surgenor AE
    Bioorg Med Chem; 2006 Jul; 14(14):4792-802. PubMed ID: 16574416
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.
    Zhao L; Zhang Y; Dai C; Guzi T; Wiswell D; Seghezzi W; Parry D; Fischmann T; Siddiqui MA
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7216-21. PubMed ID: 21074424
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.
    Foloppe N; Fisher LM; Howes R; Kierstan P; Potter A; Robertson AG; Surgenor AE
    J Med Chem; 2005 Jun; 48(13):4332-45. PubMed ID: 15974586
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of the CHK1 allosteric inhibitor binding site.
    Vanderpool D; Johnson TO; Ping C; Bergqvist S; Alton G; Phonephaly S; Rui E; Luo C; Deng YL; Grant S; Quenzer T; Margosiak S; Register J; Brown E; Ermolieff J
    Biochemistry; 2009 Oct; 48(41):9823-30. PubMed ID: 19743875
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors.
    Brnardic EJ; Garbaccio RM; Fraley ME; Tasber ES; Steen JT; Arrington KL; Dudkin VY; Hartman GD; Stirdivant SM; Drakas BA; Rickert K; Walsh ES; Hamilton K; Buser CA; Hardwick J; Tao W; Beck SC; Mao X; Lobell RB; Sepp-Lorenzino L; Yan Y; Ikuta M; Munshi SK; Kuo LC; Kreatsoulas C
    Bioorg Med Chem Lett; 2007 Nov; 17(21):5989-94. PubMed ID: 17804227
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 1.
    Dwyer MP; Paruch K; Labroli M; Alvarez C; Keertikar KM; Poker C; Rossman R; Fischmann TO; Duca JS; Madison V; Parry D; Davis N; Seghezzi W; Wiswell D; Guzi TJ
    Bioorg Med Chem Lett; 2011 Jan; 21(1):467-70. PubMed ID: 21094608
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.
    Esvan YJ; Zeinyeh W; Boibessot T; Nauton L; Théry V; Knapp S; Chaikuad A; Loaëc N; Meijer L; Anizon F; Giraud F; Moreau P
    Eur J Med Chem; 2016 Aug; 118():170-7. PubMed ID: 27128181
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.
    Oza V; Ashwell S; Brassil P; Breed J; Deng C; Ezhuthachan J; Haye H; Horn C; Janetka J; Lyne P; Newcombe N; Otterbien L; Pass M; Read J; Roswell S; Su M; Toader D; Yu D; Yu Y; Valentine A; Webborn P; White A; Zabludoff S; Zheng X
    Bioorg Med Chem Lett; 2010 Sep; 20(17):5133-8. PubMed ID: 20673630
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
    Dudkin VY; Rickert K; Kreatsoulas C; Wang C; Arrington KL; Fraley ME; Hartman GD; Yan Y; Ikuta M; Stirdivant SM; Drakas RA; Walsh ES; Hamilton K; Buser CA; Lobell RB; Sepp-Lorenzino L
    Bioorg Med Chem Lett; 2012 Apr; 22(7):2609-12. PubMed ID: 22374217
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.
    Huang X; Cheng CC; Fischmann TO; Duca JS; Richards M; Tadikonda PK; Reddy PA; Zhao L; Siddiqui MA; Parry D; Davis N; Seghezzi W; Wiswell D; Shipps GW
    Bioorg Med Chem Lett; 2013 May; 23(9):2590-4. PubMed ID: 23535330
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2.
    Labroli M; Paruch K; Dwyer MP; Alvarez C; Keertikar K; Poker C; Rossman R; Duca JS; Fischmann TO; Madison V; Parry D; Davis N; Seghezzi W; Wiswell D; Guzi TJ
    Bioorg Med Chem Lett; 2011 Jan; 21(1):471-4. PubMed ID: 21094607
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
    Garbaccio RM; Huang S; Tasber ES; Fraley ME; Yan Y; Munshi S; Ikuta M; Kuo L; Kreatsoulas C; Stirdivant S; Drakas B; Rickert K; Walsh ES; Hamilton KA; Buser CA; Hardwick J; Mao X; Beck SC; Abrams MT; Tao W; Lobell R; Sepp-Lorenzino L; Hartman GD
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6280-5. PubMed ID: 17900896
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of inhibitors of checkpoint kinase 1 through template screening.
    Matthews TP; Klair S; Burns S; Boxall K; Cherry M; Fisher M; Westwood IM; Walton MI; McHardy T; Cheung KM; Van Montfort R; Williams D; Aherne GW; Garrett MD; Reader J; Collins I
    J Med Chem; 2009 Aug; 52(15):4810-9. PubMed ID: 19572549
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
    Smaill JB; Lee HH; Palmer BD; Thompson AM; Squire CJ; Baker EN; Booth RJ; Kraker A; Hook K; Denny WA
    Bioorg Med Chem Lett; 2008 Feb; 18(3):929-33. PubMed ID: 18191399
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2.
    Hilton S; Naud S; Caldwell JJ; Boxall K; Burns S; Anderson VE; Antoni L; Allen CE; Pearl LH; Oliver AW; Wynne Aherne G; Garrett MD; Collins I
    Bioorg Med Chem; 2010 Jan; 18(2):707-18. PubMed ID: 20022510
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.
    Wenglowsky S; Ren L; Grina J; Hansen JD; Laird ER; Moreno D; Dinkel V; Gloor SL; Hastings G; Rana S; Rasor K; Sturgis HL; Voegtli WC; Vigers G; Willis B; Mathieu S; Rudolph J
    Bioorg Med Chem Lett; 2014 Apr; 24(8):1923-7. PubMed ID: 24675381
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.
    Tao ZF; Wang L; Stewart KD; Chen Z; Gu W; Bui MH; Merta P; Zhang H; Kovar P; Johnson E; Park C; Judge R; Rosenberg S; Sowin T; Lin NH
    J Med Chem; 2007 Apr; 50(7):1514-27. PubMed ID: 17352464
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
    Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ
    ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.
    Oza V; Ashwell S; Almeida L; Brassil P; Breed J; Deng C; Gero T; Grondine M; Horn C; Ioannidis S; Liu D; Lyne P; Newcombe N; Pass M; Read J; Ready S; Rowsell S; Su M; Toader D; Vasbinder M; Yu D; Yu Y; Xue Y; Zabludoff S; Janetka J
    J Med Chem; 2012 Jun; 55(11):5130-42. PubMed ID: 22551018
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.