197 related articles for article (PubMed ID: 19166355)
1. Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.
Deweese JE; Osheroff N
Biochemistry; 2009 Feb; 48(7):1439-41. PubMed ID: 19166355
[TBL] [Abstract][Full Text] [Related]
2. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.
Bender RP; Lehmler HJ; Robertson LW; Ludewig G; Osheroff N
Biochemistry; 2006 Aug; 45(33):10140-52. PubMed ID: 16906772
[TBL] [Abstract][Full Text] [Related]
3. Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.
Drwal MN; Marinello J; Manzo SG; Wakelin LP; Capranico G; Griffith R
PLoS One; 2014; 9(12):e114904. PubMed ID: 25489853
[TBL] [Abstract][Full Text] [Related]
4. Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism.
Lindsey RH; Pendleton M; Ashley RE; Mercer SL; Deweese JE; Osheroff N
Biochemistry; 2014 Oct; 53(41):6595-602. PubMed ID: 25280269
[TBL] [Abstract][Full Text] [Related]
5. Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.
Dickey JS; Osheroff N
Biochemistry; 2005 Aug; 44(34):11546-54. PubMed ID: 16114891
[TBL] [Abstract][Full Text] [Related]
6. Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
Vélez-Cruz R; Riggins JN; Daniels JS; Cai H; Guengerich FP; Marnett LJ; Osheroff N
Biochemistry; 2005 Mar; 44(10):3972-81. PubMed ID: 15751973
[TBL] [Abstract][Full Text] [Related]
7. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.
Deweese JE; Guengerich FP; Burgin AB; Osheroff N
Biochemistry; 2009 Sep; 48(38):8940-7. PubMed ID: 19697956
[TBL] [Abstract][Full Text] [Related]
8. Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain.
McClendon AK; Gentry AC; Dickey JS; Brinch M; Bendsen S; Andersen AH; Osheroff N
Biochemistry; 2008 Dec; 47(50):13169-78. PubMed ID: 19053267
[TBL] [Abstract][Full Text] [Related]
9. Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
Bender RP; Osheroff N
Chem Res Toxicol; 2007 Jun; 20(6):975-81. PubMed ID: 17516663
[TBL] [Abstract][Full Text] [Related]
10. Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha.
Deweese JE; Burgin AB; Osheroff N
Biochemistry; 2008 Apr; 47(13):4129-40. PubMed ID: 18318502
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors.
Park S; Hong E; Kwak SY; Jun KY; Lee ES; Kwon Y; Na Y
Eur J Med Chem; 2016 Nov; 123():211-225. PubMed ID: 27484510
[TBL] [Abstract][Full Text] [Related]
12. Base excision repair intermediates as topoisomerase II poisons.
Wilstermann AM; Osheroff N
J Biol Chem; 2001 Dec; 276(49):46290-6. PubMed ID: 11591703
[TBL] [Abstract][Full Text] [Related]
13. Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.
Infante Lara L; Sledge A; Laradji A; Okoro CO; Osheroff N
Bioorg Med Chem Lett; 2017 Feb; 27(3):586-589. PubMed ID: 27998679
[TBL] [Abstract][Full Text] [Related]
14. Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies.
Mandal A; Ghosh S; Bothra AK; Nanda AK; Ghosh P
Eur J Med Chem; 2012 Aug; 54():137-43. PubMed ID: 22633831
[TBL] [Abstract][Full Text] [Related]
15. HU-331 is a catalytic inhibitor of topoisomerase IIα.
Regal KM; Mercer SL; Deweese JE
Chem Res Toxicol; 2014 Dec; 27(12):2044-51. PubMed ID: 25409338
[TBL] [Abstract][Full Text] [Related]
16. Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.
Minniti E; Byl JAW; Riccardi L; Sissi C; Rosini M; De Vivo M; Minarini A; Osheroff N
Bioorg Med Chem Lett; 2017 Oct; 27(20):4687-4693. PubMed ID: 28919339
[TBL] [Abstract][Full Text] [Related]
17. The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA.
Gilroy KL; Austin CA
PLoS One; 2011 Feb; 6(2):e14693. PubMed ID: 21358820
[TBL] [Abstract][Full Text] [Related]
18. Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.
Bender RP; Ham AJ; Osheroff N
Biochemistry; 2007 Mar; 46(10):2856-64. PubMed ID: 17298034
[TBL] [Abstract][Full Text] [Related]
19. Bioflavonoids as poisons of human topoisomerase II alpha and II beta.
Bandele OJ; Osheroff N
Biochemistry; 2007 May; 46(20):6097-108. PubMed ID: 17458941
[TBL] [Abstract][Full Text] [Related]
20. Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα.
Wilson JT; Jiang X; McGill BC; Lisic EC; Deweese JE
Chem Res Toxicol; 2016 Apr; 29(4):649-58. PubMed ID: 26982206
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
