182 related articles for article (PubMed ID: 19168361)
1. Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential.
Kamal A; Rajender ; Reddy DR; Reddy MK; Balakishan G; Shaik TB; Chourasia M; Sastry GN
Bioorg Med Chem; 2009 Feb; 17(4):1557-72. PubMed ID: 19168361
[TBL] [Abstract][Full Text] [Related]
2. DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer.
Kamal A; Reddy PS; Reddy DR; Laxman E
Bioorg Med Chem; 2006 Jan; 14(2):385-94. PubMed ID: 16185884
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
Kamal A; Ramulu P; Srinivas O; Ramesh G; Kumar PP
Bioorg Med Chem Lett; 2004 Sep; 14(18):4791-4. PubMed ID: 15324909
[TBL] [Abstract][Full Text] [Related]
4. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
[TBL] [Abstract][Full Text] [Related]
5. Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents.
Kamal A; Vijaya Bharathi E; Janaki Ramaiah M; Dastagiri D; Surendranadha Reddy J; Viswanath A; Sultana F; Pushpavalli SN; Pal-Bhadra M; Srivastava HK; Narahari Sastry G; Juvekar A; Sen S; Zingde S
Bioorg Med Chem; 2010 Jan; 18(2):526-42. PubMed ID: 20031423
[TBL] [Abstract][Full Text] [Related]
6. 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
Kamal A; Khan MN; Reddy KS; Ahmed SK; Kumar MS; Juvekar A; Sen S; Zingde S
Bioorg Med Chem Lett; 2007 Oct; 17(19):5345-8. PubMed ID: 17723301
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
Kamal A; Srinivas O; Ramulu P; Ramesh G; Kumar PP; Kumar MS
Bioorg Med Chem; 2004 Aug; 12(16):4337-50. PubMed ID: 15265486
[TBL] [Abstract][Full Text] [Related]
8. The effect of C2-fluoro group on the biological activity of DC-81 and its dimers.
Kamal A; Reddy PS; Reddy DR
Bioorg Med Chem Lett; 2004 May; 14(10):2669-72. PubMed ID: 15109675
[TBL] [Abstract][Full Text] [Related]
9. Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers.
Kamal A; Ramu R; Tekumalla V; Khanna GB; Barkume MS; Juvekar AS; Zingde SM
Bioorg Med Chem; 2008 Aug; 16(15):7218-24. PubMed ID: 18656370
[TBL] [Abstract][Full Text] [Related]
10. Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
Thurston DE; Bose DS; Howard PW; Jenkins TC; Leoni A; Baraldi PG; Guiotto A; Cacciari B; Kelland LR; Foloppe MP; Rault S
J Med Chem; 1999 Jun; 42(11):1951-64. PubMed ID: 10354403
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
Kamal A; Devaiah V; Reddy KL; Kumar MS
Bioorg Med Chem; 2005 Mar; 13(6):2021-9. PubMed ID: 15727856
[TBL] [Abstract][Full Text] [Related]
12. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
Antonow D; Kaliszczak M; Kang GD; Coffils M; Tiberghien AC; Cooper N; Barata T; Heidelberger S; James CH; Zloh M; Jenkins TC; Reszka AP; Neidle S; Guichard SM; Jodrell DI; Hartley JA; Howard PW; Thurston DE
J Med Chem; 2010 Apr; 53(7):2927-41. PubMed ID: 20218628
[TBL] [Abstract][Full Text] [Related]
13. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Hartley JA; Spanswick VJ; Brooks N; Clingen PH; McHugh PJ; Hochhauser D; Pedley RB; Kelland LR; Alley MC; Schultz R; Hollingshead MG; Schweikart KM; Tomaszewski JE; Sausville EA; Gregson SJ; Howard PW; Thurston DE
Cancer Res; 2004 Sep; 64(18):6693-9. PubMed ID: 15374986
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers.
Kamal A; Rajasekhar Reddy D; Murali Mohan Reddy PS
Bioorg Med Chem Lett; 2007 Feb; 17(3):803-6. PubMed ID: 17113291
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
Howard PW; Chen Z; Gregson SJ; Masterson LA; Tiberghien AC; Cooper N; Fang M; Coffils MJ; Klee S; Hartley JA; Thurston DE
Bioorg Med Chem Lett; 2009 Nov; 19(22):6463-6. PubMed ID: 19811912
[TBL] [Abstract][Full Text] [Related]
16. Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.
Kamal A; Shankaraiah N; Prabhakar S; Reddy ChR; Markandeya N; Reddy KL; Devaiah V
Bioorg Med Chem Lett; 2008 Apr; 18(7):2434-9. PubMed ID: 18325766
[TBL] [Abstract][Full Text] [Related]
17. Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents.
Kamal A; Ramakrishna G; Lakshma Nayak V; Raju P; Subba Rao AV; Viswanath A; Vishnuvardhan MV; Ramakrishna S; Srinivas G
Bioorg Med Chem; 2012 Jan; 20(2):789-800. PubMed ID: 22209733
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity.
Kamal A; Ramesh G; Srinivas O; Ramulu P; Laxman N; Rehana T; Deepak M; Achary MS; Nagarajaram HA
Bioorg Med Chem; 2004 Oct; 12(20):5427-36. PubMed ID: 15388169
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers.
Kamal A; Prabhakar S; Janaki Ramaiah M; Venkat Reddy P; Ratna Reddy Ch; Mallareddy A; Shankaraiah N; Lakshmi Narayan Reddy T; Pushpavalli SN; Pal-Bhadra M
Eur J Med Chem; 2011 Sep; 46(9):3820-31. PubMed ID: 21676506
[TBL] [Abstract][Full Text] [Related]
20. Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
Kamal A; Kumar PP; Seshadri BN; Srinivas O; Kumar MS; Sen S; Kurian N; Juvekar AS; Zingde SM
Bioorg Med Chem; 2008 Apr; 16(7):3895-906. PubMed ID: 18262426
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]