BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 19169685)

  • 1. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.
    Conroy A; Stockett DE; Walker D; Arkin MR; Hoch U; Fox JA; Hawtin RE
    Cancer Chemother Pharmacol; 2009 Sep; 64(4):723-32. PubMed ID: 19169685
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The small-molecule CDK inhibitor, SNS-032, enhances cellular radiosensitivity in quiescent and hypoxic non-small cell lung cancer cells.
    Kodym E; Kodym R; Reis AE; Habib AA; Story MD; Saha D
    Lung Cancer; 2009 Oct; 66(1):37-47. PubMed ID: 19193471
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
    Chen R; Wierda WG; Chubb S; Hawtin RE; Fox JA; Keating MJ; Gandhi V; Plunkett W
    Blood; 2009 May; 113(19):4637-45. PubMed ID: 19234140
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma.
    Tong WG; Chen R; Plunkett W; Siegel D; Sinha R; Harvey RD; Badros AZ; Popplewell L; Coutre S; Fox JA; Mahadocon K; Chen T; Kegley P; Hoch U; Wierda WG
    J Clin Oncol; 2010 Jun; 28(18):3015-22. PubMed ID: 20479412
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo.
    Xie G; Tang H; Wu S; Chen J; Liu J; Liao C
    Int J Oncol; 2014 Aug; 45(2):804-12. PubMed ID: 24865236
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.
    Walsby E; Lazenby M; Pepper C; Burnett AK
    Leukemia; 2011 Mar; 25(3):411-9. PubMed ID: 21212792
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Anticancer activity and differentially expressed genes in head and neck cancer cells treated with a novel cyclin-dependent kinase inhibitor.
    Shin HC; Song DW; Baek WK; Lee SR; Kwon TK; Lee J; Park SH; Jang BC; Park JW
    Chemotherapy; 2009; 55(5):353-62. PubMed ID: 19657189
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
    McMillin DW; Ooi M; Delmore J; Negri J; Hayden P; Mitsiades N; Jakubikova J; Maira SM; Garcia-Echeverria C; Schlossman R; Munshi NC; Richardson PG; Anderson KC; Mitsiades CS
    Cancer Res; 2009 Jul; 69(14):5835-42. PubMed ID: 19584292
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells.
    Yenugonda VM; Deb TB; Grindrod SC; Dakshanamurthy S; Yang Y; Paige M; Brown ML
    Bioorg Med Chem; 2011 Apr; 19(8):2714-25. PubMed ID: 21440449
    [TBL] [Abstract][Full Text] [Related]  

  • 10. ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
    Löschmann N; Michaelis M; Rothweiler F; Voges Y; Balónová B; Blight BA; Cinatl J
    Oncotarget; 2016 Sep; 7(36):58051-58064. PubMed ID: 27517323
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Progress in the evaluation of CDK inhibitors as anti-tumor agents.
    McInnes C
    Drug Discov Today; 2008 Oct; 13(19-20):875-81. PubMed ID: 18639646
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Coming full circle: cyclin-dependent kinases as anti-cancer drug targets.
    Fisher RP
    Subcell Biochem; 2010; 50():1-15. PubMed ID: 20012574
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ATP-noncompetitive inhibitors of CDK-cyclin complexes.
    Orzáez M; Gortat A; Mondragón L; Bachs O; Pérez-Payá E
    ChemMedChem; 2009 Jan; 4(1):19-24. PubMed ID: 19039815
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
    McElligott AM; Maginn EN; Greene LM; McGuckin S; Hayat A; Browne PV; Butini S; Campiani G; Catherwood MA; Vandenberghe E; Williams DC; Zisterer DM; Lawler M
    Cancer Res; 2009 Nov; 69(21):8366-75. PubMed ID: 19826055
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
    Kruse U; Pallasch CP; Bantscheff M; Eberhard D; Frenzel L; Ghidelli S; Maier SK; Werner T; Wendtner CM; Drewes G
    Leukemia; 2011 Jan; 25(1):89-100. PubMed ID: 20944678
    [TBL] [Abstract][Full Text] [Related]  

  • 16. All-trans retinoic acid can intensify the growth inhibition and differentiation induction effect of rosiglitazone on multiple myeloma cells.
    Huang H; Wu D; Fu J; Chen G; Chang W; Chow HC; Leung AY; Liang R
    Eur J Haematol; 2009 Sep; 83(3):191-202. PubMed ID: 19467017
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cyclin-dependent kinase inhibitors for the treatment of chronic lymphocytic leukemia.
    Blachly JS; Byrd JC; Grever M
    Semin Oncol; 2016 Apr; 43(2):265-73. PubMed ID: 27040705
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032.
    Boquoi A; Chen T; Enders GH
    Cancer Prev Res (Phila); 2009 Sep; 2(9):800-6. PubMed ID: 19723896
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia.
    Chen Y; Germano S; Clements C; Samuel J; Shelmani G; Jayne S; Dyer MJ; Macip S
    Br J Haematol; 2016 Nov; 175(4):641-651. PubMed ID: 27469405
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
    Krystof V; Cankar P; Frysová I; Slouka J; Kontopidis G; Dzubák P; Hajdúch M; Srovnal J; de Azevedo WF; Orság M; Paprskárová M; Rolcík J; Látr A; Fischer PM; Strnad M
    J Med Chem; 2006 Nov; 49(22):6500-9. PubMed ID: 17064068
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.