196 related articles for article (PubMed ID: 19177359)
1. High tolerance to simultaneous active-site mutations in TEM-1 beta-lactamase: Distinct mutational paths provide more generalized beta-lactam recognition.
De Wals PY; Doucet N; Pelletier JN
Protein Sci; 2009 Jan; 18(1):147-60. PubMed ID: 19177359
[TBL] [Abstract][Full Text] [Related]
2. Detrimental effect of the combination of R164S with G238S in TEM-1 beta-lactamase on the extended-spectrum activity conferred by each single mutation.
Giakkoupi P; Tzelepi E; Tassios PT; Legakis NJ; Tzouvelekis LS
J Antimicrob Chemother; 2000 Jan; 45(1):101-4. PubMed ID: 10629019
[TBL] [Abstract][Full Text] [Related]
3. A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
Viadiu H; Osuna J; Fink AL; Soberón X
J Biol Chem; 1995 Jan; 270(2):781-7. PubMed ID: 7822311
[TBL] [Abstract][Full Text] [Related]
4. Mutagenesis and structural analysis reveal the CTX-M β-lactamase active site is optimized for cephalosporin catalysis and drug resistance.
Lu S; Montoya M; Hu L; Neetu N; Sankaran B; Prasad BVV; Palzkill T
J Biol Chem; 2023 May; 299(5):104630. PubMed ID: 36963495
[TBL] [Abstract][Full Text] [Related]
5. Molecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases.
Adamski CJ; Cardenas AM; Brown NG; Horton LB; Sankaran B; Prasad BV; Gilbert HF; Palzkill T
Biochemistry; 2015 Jan; 54(2):447-57. PubMed ID: 25489790
[TBL] [Abstract][Full Text] [Related]
6. Role of a mutation at position 167 of CTX-M-19 in ceftazidime hydrolysis.
Kimura S; Ishiguro M; Ishii Y; Alba J; Yamaguchi K
Antimicrob Agents Chemother; 2004 May; 48(5):1454-60. PubMed ID: 15105092
[TBL] [Abstract][Full Text] [Related]
7. A drug-resistant β-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency.
Soeung V; Lu S; Hu L; Judge A; Sankaran B; Prasad BVV; Palzkill T
J Biol Chem; 2020 Dec; 295(52):18239-18255. PubMed ID: 33109613
[TBL] [Abstract][Full Text] [Related]
8. Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity.
Guntas G; Kanwar M; Ostermeier M
PLoS One; 2012; 7(4):e35998. PubMed ID: 22536452
[TBL] [Abstract][Full Text] [Related]
9. Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli.
Vakulenko SB; Taibi-Tronche P; Tóth M; Massova I; Lerner SA; Mobashery S
J Biol Chem; 1999 Aug; 274(33):23052-60. PubMed ID: 10438473
[TBL] [Abstract][Full Text] [Related]
10. Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase.
Petrosino JF; Palzkill T
J Bacteriol; 1996 Apr; 178(7):1821-8. PubMed ID: 8606154
[TBL] [Abstract][Full Text] [Related]
11. Mass spectral kinetic study of acylation and deacylation during the hydrolysis of penicillins and cefotaxime by beta-lactamase TEM-1 and the G238S mutant.
Saves I; Burlet-Schiltz O; Maveyraud L; Samama JP; Promé JC; Masson JM
Biochemistry; 1995 Sep; 34(37):11660-7. PubMed ID: 7547898
[TBL] [Abstract][Full Text] [Related]
12. Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase.
Marciano DC; Brown NG; Palzkill T
Protein Sci; 2009 Oct; 18(10):2080-9. PubMed ID: 19672877
[TBL] [Abstract][Full Text] [Related]
13. Structure-function studies of arginine at position 276 in CTX-M beta-lactamases.
Pérez-Llarena FJ; Cartelle M; Mallo S; Beceiro A; Pérez A; Villanueva R; Romero A; Bonnet R; Bou G
J Antimicrob Chemother; 2008 Apr; 61(4):792-7. PubMed ID: 18281307
[TBL] [Abstract][Full Text] [Related]
14. Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance.
Novais A; Cantón R; Coque TM; Moya A; Baquero F; Galán JC
Antimicrob Agents Chemother; 2008 Jul; 52(7):2377-82. PubMed ID: 18443114
[TBL] [Abstract][Full Text] [Related]
15. A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.
Stojanoski V; Chow DC; Hu L; Sankaran B; Gilbert HF; Prasad BV; Palzkill T
J Biol Chem; 2015 Apr; 290(16):10382-94. PubMed ID: 25713062
[TBL] [Abstract][Full Text] [Related]
16. Selection strategy for site-directed mutagenesis based on altered beta-lactamase specificity.
Andrews CA; Lesley SA
Biotechniques; 1998 Jun; 24(6):972-4, 976, 978 passim. PubMed ID: 9631188
[TBL] [Abstract][Full Text] [Related]
17. Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase.
Judge A; Hu L; Sankaran B; Van Riper J; Venkataram Prasad BV; Palzkill T
Commun Biol; 2023 Jan; 6(1):35. PubMed ID: 36635385
[TBL] [Abstract][Full Text] [Related]
18. Substitution of Thr for Ala-237 in TEM-17, TEM-12 and TEM-26: alterations in beta-lactam resistance conferred on Escherichia coli.
Giakkoupi P; Hujer AM; Miriagou V; Tzelepi E; Bonomo RA; Tzouvelekis LS
FEMS Microbiol Lett; 2001 Jul; 201(1):37-40. PubMed ID: 11445164
[TBL] [Abstract][Full Text] [Related]
19. Contribution of PBP3 Substitutions and TEM-1, TEM-15, and ROB-1 Beta-Lactamases to Cefotaxime Resistance in Haemophilus influenzae and Haemophilus parainfluenzae.
Søndergaard A; Nørskov-Lauritsen N
Microb Drug Resist; 2016 Jun; 22(4):247-52. PubMed ID: 26683319
[TBL] [Abstract][Full Text] [Related]
20. Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance.
Patel MP; Hu L; Brown CA; Sun Z; Adamski CJ; Stojanoski V; Sankaran B; Prasad BVV; Palzkill T
J Biol Chem; 2018 Nov; 293(46):17971-17984. PubMed ID: 30275013
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
