These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Amino acid residues that define both the isoprenoid and CAAX preferences of the Saccharomyces cerevisiae protein farnesyltransferase. Creating the perfect farnesyltransferase. Caplin BE; Ohya Y; Marshall MS J Biol Chem; 1998 Apr; 273(16):9472-9. PubMed ID: 9545274 [TBL] [Abstract][Full Text] [Related]
5. Quantitative determination of cellular farnesyltransferase activity: towards defining the minimum substrate reactivity for biologically relevant protein farnesylation. Flynn SC; Lindgren DE; Hougland JL Chembiochem; 2014 Oct; 15(15):2205-10. PubMed ID: 25182009 [TBL] [Abstract][Full Text] [Related]
6. Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Terry KL; Casey PJ; Beese LS Biochemistry; 2006 Aug; 45(32):9746-55. PubMed ID: 16893176 [TBL] [Abstract][Full Text] [Related]
7. Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. Hougland JL; Gangopadhyay SA; Fierke CA J Biol Chem; 2012 Nov; 287(45):38090-100. PubMed ID: 22992747 [TBL] [Abstract][Full Text] [Related]
8. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. Reid TS; Terry KL; Casey PJ; Beese LS J Mol Biol; 2004 Oct; 343(2):417-33. PubMed ID: 15451670 [TBL] [Abstract][Full Text] [Related]
9. Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. London N; Lamphear CL; Hougland JL; Fierke CA; Schueler-Furman O PLoS Comput Biol; 2011 Oct; 7(10):e1002170. PubMed ID: 21998565 [TBL] [Abstract][Full Text] [Related]
10. Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity. Hartman HL; Hicks KA; Fierke CA Biochemistry; 2005 Nov; 44(46):15314-24. PubMed ID: 16285735 [TBL] [Abstract][Full Text] [Related]
11. Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition. Gangopadhyay SA; Losito EL; Hougland JL Biochemistry; 2014 Jan; 53(2):434-46. PubMed ID: 24344934 [TBL] [Abstract][Full Text] [Related]
12. MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase. Schey GL; Buttery PH; Hildebrandt ER; Novak SX; Schmidt WK; Hougland JL; Distefano MD Int J Mol Sci; 2021 Nov; 22(21):. PubMed ID: 34769472 [TBL] [Abstract][Full Text] [Related]
13. Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase. Schey GL; Hildebrandt ER; Wang Y; Diwan S; Passetti HA; Potts GW; Sprague-Getsy AM; Leoni ER; Kuebler TS; Sham YY; Hougland JL; Beese LS; Schmidt WK; Distefano MD Int J Mol Sci; 2024 May; 25(10):. PubMed ID: 38791363 [TBL] [Abstract][Full Text] [Related]
14. Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries. Krzysiak AJ; Scott SA; Hicks KA; Fierke CA; Gibbs RA Bioorg Med Chem Lett; 2007 Oct; 17(20):5548-51. PubMed ID: 17804232 [TBL] [Abstract][Full Text] [Related]
15. A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences. Kim JH; Hildebrandt ER; Sarkar A; Yeung W; Waldon RA; Kannan N; Schmidt WK G3 (Bethesda); 2023 Jul; 13(7):. PubMed ID: 37119806 [TBL] [Abstract][Full Text] [Related]
17. Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I. Hicks KA; Hartman HL; Fierke CA Biochemistry; 2005 Nov; 44(46):15325-33. PubMed ID: 16285736 [TBL] [Abstract][Full Text] [Related]
18. Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release. Troutman JM; Andres DA; Spielmann HP Biochemistry; 2007 Oct; 46(40):11299-309. PubMed ID: 17877368 [TBL] [Abstract][Full Text] [Related]
19. Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae. Trueblood CE; Ohya Y; Rine J Mol Cell Biol; 1993 Jul; 13(7):4260-75. PubMed ID: 8321228 [TBL] [Abstract][Full Text] [Related]
20. Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic. Roskoski R; Ritchie PA Biochemistry; 2001 Aug; 40(31):9329-35. PubMed ID: 11478901 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]