BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

217 related articles for article (PubMed ID: 19200002)

  • 1. Methodologies to assess brain drug delivery in lead optimization.
    Hammarlund-Udenaes M; Bredberg U; Fridén M
    Curr Top Med Chem; 2009; 9(2):148-62. PubMed ID: 19200002
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems.
    Liu H; Dong K; Zhang W; Summerfield SG; Terstappen GC
    Drug Discov Today; 2018 Jul; 23(7):1357-1372. PubMed ID: 29548981
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Progress in brain penetration evaluation in drug discovery and development.
    Liu X; Chen C; Smith BJ
    J Pharmacol Exp Ther; 2008 May; 325(2):349-56. PubMed ID: 18203948
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Demystifying brain penetration in central nervous system drug discovery. Miniperspective.
    Di L; Rong H; Feng B
    J Med Chem; 2013 Jan; 56(1):2-12. PubMed ID: 23075026
    [TBL] [Abstract][Full Text] [Related]  

  • 5. New experimental models of the blood-brain barrier for CNS drug discovery.
    Kaisar MA; Sajja RK; Prasad S; Abhyankar VV; Liles T; Cucullo L
    Expert Opin Drug Discov; 2017 Jan; 12(1):89-103. PubMed ID: 27782770
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Current State and Future Perspectives in QSAR Models to Predict Blood- Brain Barrier Penetration in Central Nervous System Drug R&D.
    Morales JF; Montoto SS; Fagiolino P; Ruiz ME
    Mini Rev Med Chem; 2017; 17(3):247-257. PubMed ID: 27739359
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development.
    Ohtsuki S; Terasaki T
    Pharm Res; 2007 Sep; 24(9):1745-58. PubMed ID: 17619998
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: from discovery to patients.
    de Lange EC; Hammarlund-Udenaes M
    Clin Pharmacol Ther; 2015 Apr; 97(4):380-94. PubMed ID: 25670219
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates.
    Loryan I; Sinha V; Mackie C; Van Peer A; Drinkenburg WH; Vermeulen A; Heald D; Hammarlund-Udenaes M; Wassvik CM
    Mol Pharm; 2015 Feb; 12(2):520-32. PubMed ID: 25496026
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB).
    Helms HCC; Kristensen M; Saaby L; Fricker G; Brodin B
    Handb Exp Pharmacol; 2022; 273():151-183. PubMed ID: 33367937
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A method to predict different mechanisms for blood-brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine.
    Jiang L; Chen J; He Y; Zhang Y; Li G
    J Bioinform Comput Biol; 2016 Feb; 14(1):1650005. PubMed ID: 26632324
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System.
    Zhang YY; Liu H; Summerfield SG; Luscombe CN; Sahi J
    Mol Pharm; 2016 May; 13(5):1540-50. PubMed ID: 27015243
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Recent advances in medicinal chemistry and pharmaceutical technology--strategies for drug delivery to the brain.
    Denora N; Trapani A; Laquintana V; Lopedota A; Trapani G
    Curr Top Med Chem; 2009; 9(2):182-96. PubMed ID: 19200004
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Confounding parameters in preclinical assessment of blood-brain barrier permeation: an overview with emphasis on species differences and effect of disease states.
    Deo AK; Theil FP; Nicolas JM
    Mol Pharm; 2013 May; 10(5):1581-95. PubMed ID: 23256608
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impact of transporters and enzymes from blood-cerebrospinal fluid barrier and brain parenchyma on CNS drug uptake.
    Wang Q; Zuo Z
    Expert Opin Drug Metab Toxicol; 2018 Sep; 14(9):961-972. PubMed ID: 30118608
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CNS drug design: balancing physicochemical properties for optimal brain exposure.
    Rankovic Z
    J Med Chem; 2015 Mar; 58(6):2584-608. PubMed ID: 25494650
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery.
    Pardridge WM
    Expert Opin Ther Targets; 2015; 19(8):1059-72. PubMed ID: 25936389
    [TBL] [Abstract][Full Text] [Related]  

  • 18. From naturally-occurring neurotoxic agents to CNS shuttles for drug delivery.
    Soddu E; Rassu G; Giunchedi P; Sarmento B; Gavini E
    Eur J Pharm Sci; 2015 Jul; 74():63-76. PubMed ID: 25892455
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Current advances in delivery of biotherapeutics across the blood-brain barrier.
    Rajadhyaksha M; Boyden T; Liras J; El-Kattan A; Brodfuehrer J
    Curr Drug Discov Technol; 2011 Jun; 8(2):87-101. PubMed ID: 21513485
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [Multi-disciplinary research approaches on the brain barrier transport system, a dynamic interface].
    Tachikawa M; Uchida Y; Terasaki T
    Brain Nerve; 2013 Feb; 65(2):121-36. PubMed ID: 23399670
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.