BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

96 related articles for article (PubMed ID: 19226162)

  • 1. Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
    Wagner R; Larson DP; Beno DW; Bosse TD; Darbyshire JF; Gao Y; Gates BD; He W; Henry RF; Hernandez LE; Hutchinson DK; Jiang WW; Kati WM; Klein LL; Koev G; Kohlbrenner W; Krueger AC; Liu J; Liu Y; Long MA; Maring CJ; Masse SV; Middleton T; Montgomery DA; Pratt JK; Stuart P; Molla A; Kempf DJ
    J Med Chem; 2009 Mar; 52(6):1659-69. PubMed ID: 19226162
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.
    Randolph JT; Flentge CA; Huang PP; Hutchinson DK; Klein LL; Lim HB; Mondal R; Reisch T; Montgomery DA; Jiang WW; Masse SV; Hernandez LE; Henry RF; Liu Y; Koev G; Kati WM; Stewart KD; Beno DW; Molla A; Kempf DJ
    J Med Chem; 2009 May; 52(10):3174-83. PubMed ID: 19402666
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.
    Bosse TD; Larson DP; Wagner R; Hutchinson DK; Rockway TW; Kati WM; Liu Y; Masse S; Middleton T; Mo H; Montgomery D; Jiang W; Koev G; Kempf DJ; Molla A
    Bioorg Med Chem Lett; 2008 Jan; 18(2):568-70. PubMed ID: 18068361
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
    Tedesco R; Shaw AN; Bambal R; Chai D; Concha NO; Darcy MG; Dhanak D; Fitch DM; Gates A; Gerhardt WG; Halegoua DL; Han C; Hofmann GA; Johnston VK; Kaura AC; Liu N; Keenan RM; Lin-Goerke J; Sarisky RT; Wiggall KJ; Zimmerman MN; Duffy KJ
    J Med Chem; 2006 Feb; 49(3):971-83. PubMed ID: 16451063
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.
    Chen CM; He Y; Lu L; Lim HB; Tripathi RL; Middleton T; Hernandez LE; Beno DW; Long MA; Kati WM; Bosse TD; Larson DP; Wagner R; Lanford RE; Kohlbrenner WE; Kempf DJ; Pilot-Matias TJ; Molla A
    Antimicrob Agents Chemother; 2007 Dec; 51(12):4290-6. PubMed ID: 17908950
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro.
    Lu L; Dekhtyar T; Masse S; Pithawalla R; Krishnan P; He W; Ng T; Koev G; Stewart K; Larson D; Bosse T; Wagner R; Pilot-Matias T; Mo H; Molla A
    Antiviral Res; 2007 Oct; 76(1):93-7. PubMed ID: 17561278
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives.
    Krueger AC; Madigan DL; Green BE; Hutchinson DK; Jiang WW; Kati WM; Liu Y; Maring CJ; Masse SV; McDaniel KF; Middleton TR; Mo H; Molla A; Montgomery DA; Ng TI; Kempf DJ
    Bioorg Med Chem Lett; 2007 Apr; 17(8):2289-92. PubMed ID: 17300933
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
    Hendricks RT; Fell JB; Blake JF; Fischer JP; Robinson JE; Spencer SR; Stengel PJ; Bernacki AL; Leveque VJ; Le Pogam S; Rajyaguru S; Najera I; Josey JA; Harris JR; Swallow S
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3637-41. PubMed ID: 19447623
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aminothiazole inhibitors of HCV RNA polymerase.
    Shipps GW; Deng Y; Wang T; Popovici-Muller J; Curran PJ; Rosner KE; Cooper AB; Girijavallabhan V; Butkiewicz N; Cable M
    Bioorg Med Chem Lett; 2005 Jan; 15(1):115-9. PubMed ID: 15582422
    [TBL] [Abstract][Full Text] [Related]  

  • 10. New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection.
    Stankiewicz-Drogon A; Palchykovska LG; Kostina VG; Alexeeva IV; Shved AD; Boguszewska-Chachulska AM
    Bioorg Med Chem; 2008 Oct; 16(19):8846-52. PubMed ID: 18801660
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
    Donner PL; Xie Q; Pratt JK; Maring CJ; Kati W; Jiang W; Liu Y; Koev G; Masse S; Montgomery D; Molla A; Kempf DJ
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2735-8. PubMed ID: 18362072
    [TBL] [Abstract][Full Text] [Related]  

  • 12. HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
    Wang G; He Y; Sun J; Das D; Hu M; Huang J; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Stoycheva A; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4476-9. PubMed ID: 19502055
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Integrated structure-based activity prediction model of benzothiadiazines on various genotypes of HCV NS5b polymerase (1a, 1b and 4) and its application in the discovery of new derivatives.
    Ismail MA; Abou El Ella DA; Abouzid KA; Mahmoud AH
    Bioorg Med Chem; 2012 Apr; 20(7):2455-78. PubMed ID: 22386565
    [TBL] [Abstract][Full Text] [Related]  

  • 14. HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives.
    Wang G; Zhang L; Wu X; Das D; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4484-7. PubMed ID: 19497737
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor.
    Nguyen TT; Gates AT; Gutshall LL; Johnston VK; Gu B; Duffy KJ; Sarisky RT
    Antimicrob Agents Chemother; 2003 Nov; 47(11):3525-30. PubMed ID: 14576112
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Toward second generation hepatitis C virus NS3 serine protease inhibitors: discovery of novel P4 modified analogues with improved potency and pharmacokinetic profile.
    Arasappan A; Padilla AI; Jao E; Bennett F; Bogen SL; Chen KX; Pike RE; Sannigrahi M; Soares J; Venkatraman S; Vibulbhan B; Saksena AK; Girijavallabhan V; Tong X; Cheng KC; Njoroge FG
    J Med Chem; 2009 May; 52(9):2806-17. PubMed ID: 19371095
    [TBL] [Abstract][Full Text] [Related]  

  • 17. An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
    Evans KA; Chai D; Graybill TL; Burton G; Sarisky RT; Lin-Goerke J; Johnston VK; Rivero RA
    Bioorg Med Chem Lett; 2006 Apr; 16(8):2205-8. PubMed ID: 16455253
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.
    Pratt JK; Donner P; McDaniel KF; Maring CJ; Kati WM; Mo H; Middleton T; Liu Y; Ng T; Xie Q; Zhang R; Montgomery D; Molla A; Kempf DJ; Kohlbrenner W
    Bioorg Med Chem Lett; 2005 Mar; 15(6):1577-82. PubMed ID: 15745800
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
    Wang G; Lei H; Wang X; Das D; Hong J; Mackinnon CH; Coulter TS; Montalbetti CA; Mears R; Gai X; Bailey SE; Ruhrmund D; Hooi L; Misialek S; Rajagopalan PT; Cheng RK; Barker JJ; Felicetti B; Schönfeld DL; Stoycheva A; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4480-3. PubMed ID: 19500983
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase.
    Popovici-Muller J; Shipps GW; Rosner KE; Deng Y; Wang T; Curran PJ; Brown MA; Siddiqui MA; Cooper AB; Duca J; Cable M; Girijavallabhan V
    Bioorg Med Chem Lett; 2009 Nov; 19(22):6331-6. PubMed ID: 19819138
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.