473 related articles for article (PubMed ID: 19240132)
1. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.
Knuesel MT; Meyer KD; Bernecky C; Taatjes DJ
Genes Dev; 2009 Feb; 23(4):439-51. PubMed ID: 19240132
[TBL] [Abstract][Full Text] [Related]
2. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.
Knuesel MT; Meyer KD; Donner AJ; Espinosa JM; Taatjes DJ
Mol Cell Biol; 2009 Feb; 29(3):650-61. PubMed ID: 19047373
[TBL] [Abstract][Full Text] [Related]
3. Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.
Belakavadi M; Fondell JD
Mol Cell Biol; 2010 May; 30(10):2437-48. PubMed ID: 20231357
[TBL] [Abstract][Full Text] [Related]
4. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
[TBL] [Abstract][Full Text] [Related]
5. Regulatory functions of the Mediator kinases CDK8 and CDK19.
Fant CB; Taatjes DJ
Transcription; 2019 Apr; 10(2):76-90. PubMed ID: 30585107
[TBL] [Abstract][Full Text] [Related]
6. Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.
Andrau JC; van de Pasch L; Lijnzaad P; Bijma T; Koerkamp MG; van de Peppel J; Werner M; Holstege FC
Mol Cell; 2006 Apr; 22(2):179-92. PubMed ID: 16630888
[TBL] [Abstract][Full Text] [Related]
7. MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.
Sooraj D; Sun C; Doan A; Garama DJ; Dannappel MV; Zhu D; Chua HK; Mahara S; Wan Hassan WA; Tay YK; Guanizo A; Croagh D; Prodanovic Z; Gough DJ; Wan C; Firestein R
Mol Cell; 2022 Jan; 82(1):123-139.e7. PubMed ID: 34910943
[TBL] [Abstract][Full Text] [Related]
8. A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.
Furumoto T; Tanaka A; Ito M; Malik S; Hirose Y; Hanaoka F; Ohkuma Y
Genes Cells; 2007 Jan; 12(1):119-32. PubMed ID: 17212659
[TBL] [Abstract][Full Text] [Related]
9. Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells.
Kuuluvainen E; Domènech-Moreno E; Niemelä EH; Mäkelä TP
Mol Cell Biol; 2018 Jun; 38(11):. PubMed ID: 29507187
[TBL] [Abstract][Full Text] [Related]
10. Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.
Kuuluvainen E; Hakala H; Havula E; Sahal Estimé M; Rämet M; Hietakangas V; Mäkelä TP
J Biol Chem; 2014 Jun; 289(23):16252-61. PubMed ID: 24778181
[TBL] [Abstract][Full Text] [Related]
11. The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.
Elmlund H; Baraznenok V; Lindahl M; Samuelsen CO; Koeck PJ; Holmberg S; Hebert H; Gustafsson CM
Proc Natl Acad Sci U S A; 2006 Oct; 103(43):15788-93. PubMed ID: 17043218
[TBL] [Abstract][Full Text] [Related]
12. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.
Meyer KD; Donner AJ; Knuesel MT; York AG; Espinosa JM; Taatjes DJ
EMBO J; 2008 May; 27(10):1447-57. PubMed ID: 18418385
[TBL] [Abstract][Full Text] [Related]
13. The Mediator kinase module: an interface between cell signaling and transcription.
Luyties O; Taatjes DJ
Trends Biochem Sci; 2022 Apr; 47(4):314-327. PubMed ID: 35193797
[TBL] [Abstract][Full Text] [Related]
14. A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
Gobert V; Osman D; Bras S; Augé B; Boube M; Bourbon HM; Horn T; Boutros M; Haenlin M; Waltzer L
Mol Cell Biol; 2010 Jun; 30(11):2837-48. PubMed ID: 20368357
[TBL] [Abstract][Full Text] [Related]
15. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
Klatt F; Leitner A; Kim IV; Ho-Xuan H; Schneider EV; Langhammer F; Weinmann R; Müller MR; Huber R; Meister G; Kuhn CD
Proc Natl Acad Sci U S A; 2020 Feb; 117(6):2894-2905. PubMed ID: 31988137
[TBL] [Abstract][Full Text] [Related]
16. Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.
Law MJ; Ciccaglione K
Genetics; 2015 Feb; 199(2):435-53. PubMed ID: 25467068
[TBL] [Abstract][Full Text] [Related]
17. Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme.
Rovnak J; Quackenbush SL
J Virol; 2002 Aug; 76(16):8031-9. PubMed ID: 12134008
[TBL] [Abstract][Full Text] [Related]
18. MED12 interacts with the heat-shock transcription factor HSF1 and recruits CDK8 to promote the heat-shock response in mammalian cells.
Srivastava P; Takii R; Okada M; Fujimoto M; Nakai A
FEBS Lett; 2021 Jul; 595(14):1933-1948. PubMed ID: 34056708
[TBL] [Abstract][Full Text] [Related]
19. De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.
Calpena E; Hervieu A; Kaserer T; Swagemakers SMA; Goos JAC; Popoola O; Ortiz-Ruiz MJ; Barbaro-Dieber T; Bownass L; Brilstra EH; Brimble E; Foulds N; Grebe TA; Harder AVE; Lees MM; Monaghan KG; Newbury-Ecob RA; Ong KR; Osio D; Reynoso Santos FJ; Ruzhnikov MRZ; Telegrafi A; van Binsbergen E; van Dooren MF; ; van der Spek PJ; Blagg J; Twigg SRF; Mathijssen IMJ; Clarke PA; Wilkie AOM
Am J Hum Genet; 2019 Apr; 104(4):709-720. PubMed ID: 30905399
[TBL] [Abstract][Full Text] [Related]
20. Mediator kinase module and human tumorigenesis.
Clark AD; Oldenbroek M; Boyer TG
Crit Rev Biochem Mol Biol; 2015; 50(5):393-426. PubMed ID: 26182352
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]