BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

241 related articles for article (PubMed ID: 19251824)

  • 21. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
    Faucette SR; Sueyoshi T; Smith CM; Negishi M; Lecluyse EL; Wang H
    J Pharmacol Exp Ther; 2006 Jun; 317(3):1200-9. PubMed ID: 16513849
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.
    Lim YP; Cheng CH; Chen WC; Chang SY; Hung DZ; Chen JJ; Wan L; Ma WC; Lin YH; Chen CY; Yokoi T; Nakajima M; Chen CJ
    Arch Toxicol; 2015 Jan; 89(1):57-72. PubMed ID: 25069801
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.
    Banerjee M; Chen T
    Biochem Pharmacol; 2013 Sep; 86(6):824-35. PubMed ID: 23928187
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
    Gupta A; Mugundu GM; Desai PB; Thummel KE; Unadkat JD
    Drug Metab Dispos; 2008 Jun; 36(6):1172-80. PubMed ID: 18332086
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
    Zhang J; Kuehl P; Green ED; Touchman JW; Watkins PB; Daly A; Hall SD; Maurel P; Relling M; Brimer C; Yasuda K; Wrighton SA; Hancock M; Kim RB; Strom S; Thummel K; Russell CG; Hudson JR; Schuetz EG; Boguski MS
    Pharmacogenetics; 2001 Oct; 11(7):555-72. PubMed ID: 11668216
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
    El-Sankary W; Bombail V; Gibson GG; Plant N
    Drug Metab Dispos; 2002 Sep; 30(9):1029-34. PubMed ID: 12167569
    [TBL] [Abstract][Full Text] [Related]  

  • 27. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.
    Tan H; Xu C; Zeng H; Wang Y; Li Y; Fan X; Chen P; Jiang Y; Chen X; Huang M; Bi H
    J Pharmacol Sci; 2016 Feb; 130(2):66-71. PubMed ID: 26782648
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).
    Burk O; Koch I; Raucy J; Hustert E; Eichelbaum M; Brockmöller J; Zanger UM; Wojnowski L
    J Biol Chem; 2004 Sep; 279(37):38379-85. PubMed ID: 15252010
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury.
    Wang YG; Zhou JM; Ma ZC; Li H; Liang QD; Tan HL; Xiao CR; Zhang BL; Gao Y
    Chem Biol Interact; 2012 Oct; 200(1):11-20. PubMed ID: 22982774
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation.
    Sivertsson L; Edebert I; Palmertz MP; Ingelman-Sundberg M; Neve EP
    Mol Pharmacol; 2013 Mar; 83(3):659-70. PubMed ID: 23264496
    [TBL] [Abstract][Full Text] [Related]  

  • 31. NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction.
    Mitamura R; Nakano M; Isono M; Kurosawa K; Fukami T; Nakajima M
    Drug Metab Dispos; 2023 Oct; 51(10):1230-1237. PubMed ID: 37349114
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC; Das PC; Dekrey GK; Gardiner CS; Cao Y; Rose RL; Wallace AD
    Toxicol Appl Pharmacol; 2010 Jun; 245(3):335-43. PubMed ID: 20361990
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
    Kim S; Dinchuk JE; Anthony MN; Orcutt T; Zoeckler ME; Sauer MB; Mosure KW; Vuppugalla R; Grace JE; Simmermacher J; Dulac HA; Pizzano J; Sinz M
    Drug Metab Dispos; 2010 Jan; 38(1):16-24. PubMed ID: 19833845
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.
    Carazo A; Hyrsova L; Dusek J; Chodounska H; Horvatova A; Berka K; Bazgier V; Gan-Schreier H; Chamulitrat W; Kudova E; Pavek P
    Toxicol Lett; 2017 Jan; 265():86-96. PubMed ID: 27871908
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
    Ma X; Cheung C; Krausz KW; Shah YM; Wang T; Idle JR; Gonzalez FJ
    Drug Metab Dispos; 2008 Dec; 36(12):2506-12. PubMed ID: 18799805
    [TBL] [Abstract][Full Text] [Related]  

  • 36. PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
    Yu C; Ye S; Sun H; Liu Y; Gao L; Shen C; Chen S; Zeng S
    Chem Biol Interact; 2009 Jan; 177(1):58-64. PubMed ID: 18805405
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
    Thummel KE; Brimer C; Yasuda K; Thottassery J; Senn T; Lin Y; Ishizuka H; Kharasch E; Schuetz J; Schuetz E
    Mol Pharmacol; 2001 Dec; 60(6):1399-406. PubMed ID: 11723248
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.
    Sugatani J; Yamakawa K; Tonda E; Nishitani S; Yoshinari K; Degawa M; Abe I; Noguchi H; Miwa M
    Biochem Pharmacol; 2004 Mar; 67(5):989-1000. PubMed ID: 15104253
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
    Istrate MA; Nussler AK; Eichelbaum M; Burk O
    Biochem Biophys Res Commun; 2010 Mar; 393(4):688-93. PubMed ID: 20171174
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics.
    Takeshita A; Taguchi M; Koibuchi N; Ozawa Y
    J Biol Chem; 2002 Sep; 277(36):32453-8. PubMed ID: 12072427
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.