892 related articles for article (PubMed ID: 19285987)
1. Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.
Finlay WJ; Cunningham O; Lambert MA; Darmanin-Sheehan A; Liu X; Fennell BJ; Mahon CM; Cummins E; Wade JM; O'Sullivan CM; Tan XY; Piche N; Pittman DD; Paulsen J; Tchistiakova L; Kodangattil S; Gill D; Hufton SE
J Mol Biol; 2009 May; 388(3):541-58. PubMed ID: 19285987
[TBL] [Abstract][Full Text] [Related]
2. Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues.
Wu H; Nie Y; Huse WD; Watkins JD
J Mol Biol; 1999 Nov; 294(1):151-62. PubMed ID: 10556035
[TBL] [Abstract][Full Text] [Related]
3. Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site.
Schier R; McCall A; Adams GP; Marshall KW; Merritt H; Yim M; Crawford RS; Weiner LM; Marks C; Marks JD
J Mol Biol; 1996 Nov; 263(4):551-67. PubMed ID: 8918938
[TBL] [Abstract][Full Text] [Related]
4. Affinity maturation of a V(H)H by mutational hotspot randomization.
Yau KY; Dubuc G; Li S; Hirama T; Mackenzie CR; Jermutus L; Hall JC; Tanha J
J Immunol Methods; 2005 Feb; 297(1-2):213-24. PubMed ID: 15777944
[TBL] [Abstract][Full Text] [Related]
5. Improvement of anti-Burkholderia mouse monoclonal antibody from various phage-displayed single-chain antibody libraries.
Kim HS; Lo SC; Wear DJ; Stojadinovic A; Weina PJ; Izadjoo MJ
J Immunol Methods; 2011 Sep; 372(1-2):146-61. PubMed ID: 21787781
[TBL] [Abstract][Full Text] [Related]
6. Affinity maturation of a high-affinity human monoclonal antibody against the third hypervariable loop of human immunodeficiency virus: use of phage display to improve affinity and broaden strain reactivity.
Thompson J; Pope T; Tung JS; Chan C; Hollis G; Mark G; Johnson KS
J Mol Biol; 1996 Feb; 256(1):77-88. PubMed ID: 8609615
[TBL] [Abstract][Full Text] [Related]
7. Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.
Beiboer SH; Reurs A; Roovers RC; Arends JW; Whitelegg NR; Rees AR; Hoogenboom HR
J Mol Biol; 2000 Feb; 296(3):833-49. PubMed ID: 10677285
[TBL] [Abstract][Full Text] [Related]
8. In vitro antibody maturation. Improvement of a high affinity, neutralizing antibody against IL-1 beta.
Jackson JR; Sathe G; Rosenberg M; Sweet R
J Immunol; 1995 Apr; 154(7):3310-9. PubMed ID: 7897213
[TBL] [Abstract][Full Text] [Related]
9. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
Chen Y; Wiesmann C; Fuh G; Li B; Christinger HW; McKay P; de Vos AM; Lowman HB
J Mol Biol; 1999 Nov; 293(4):865-81. PubMed ID: 10543973
[TBL] [Abstract][Full Text] [Related]
10. Anti-estradiol-17beta single-chain Fv fragments: Generation, characterization, gene randomization, and optimized phage display.
Kobayashi N; Kato Y; Oyama H; Taga S; Niwa T; Sun P; Ohtoyo M; Goto J
Steroids; 2008 Dec; 73(14):1485-99. PubMed ID: 18824188
[TBL] [Abstract][Full Text] [Related]
11. Enhanced antibody affinity to Japanese encephalitis virus E protein by phage display.
Hong WW; Yen YH; Wu SC
Biochem Biophys Res Commun; 2007 Apr; 356(1):124-8. PubMed ID: 17350601
[TBL] [Abstract][Full Text] [Related]
12. The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin.
Giles I; Lambrianides N; Latchman D; Chen P; Chukwuocha R; Isenberg D; Rahman A
Arthritis Res Ther; 2005; 7(1):R47-56. PubMed ID: 15642142
[TBL] [Abstract][Full Text] [Related]
13. Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.
Sidhu SS; Li B; Chen Y; Fellouse FA; Eigenbrot C; Fuh G
J Mol Biol; 2004 Apr; 338(2):299-310. PubMed ID: 15066433
[TBL] [Abstract][Full Text] [Related]
14. In vitro affinity maturation of a specificity-determining region-grafted humanized anticarcinoma antibody: isolation and characterization of minimally immunogenic high-affinity variants.
De Pascalis R; Gonzales NR; Padlan EA; Schuck P; Batra SK; Schlom J; Kashmiri SV
Clin Cancer Res; 2003 Nov; 9(15):5521-31. PubMed ID: 14654532
[TBL] [Abstract][Full Text] [Related]
15. SDR grafting--a new approach to antibody humanization.
Kashmiri SV; De Pascalis R; Gonzales NR; Schlom J
Methods; 2005 May; 36(1):25-34. PubMed ID: 15848072
[TBL] [Abstract][Full Text] [Related]
16. Humanization of a highly stable single-chain antibody by structure-based antigen-binding site grafting.
Villani ME; Morea V; Consalvi V; Chiaraluce R; Desiderio A; Benvenuto E; Donini M
Mol Immunol; 2008 May; 45(9):2474-85. PubMed ID: 18313757
[TBL] [Abstract][Full Text] [Related]
17. Dissection of the IgNAR V domain: molecular scanning and orthologue database mining define novel IgNAR hallmarks and affinity maturation mechanisms.
Fennell BJ; Darmanin-Sheehan A; Hufton SE; Calabro V; Wu L; Müller MR; Cao W; Gill D; Cunningham O; Finlay WJ
J Mol Biol; 2010 Jul; 400(2):155-70. PubMed ID: 20450918
[TBL] [Abstract][Full Text] [Related]
18. Affinity maturation of phage display antibody populations using ribosome display.
Groves M; Lane S; Douthwaite J; Lowne D; Rees DG; Edwards B; Jackson RH
J Immunol Methods; 2006 Jun; 313(1-2):129-39. PubMed ID: 16730741
[TBL] [Abstract][Full Text] [Related]
19. Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.
Lowe DC; Gerhardt S; Ward A; Hargreaves D; Anderson M; Ferraro F; Pauptit RA; Pattison DV; Buchanan C; Popovic B; Finch DK; Wilkinson T; Sleeman M; Vaughan TJ; Mallinder PR
J Mol Biol; 2011 Feb; 406(1):160-75. PubMed ID: 21167836
[TBL] [Abstract][Full Text] [Related]
20. Affinity maturation of the BR96 anti-carcinoma antibody by codon-based mutagenesis.
Yelton DE; Rosok MJ; Cruz G; Cosand WL; Bajorath J; Hellström I; Hellström KE; Huse WD; Glaser SM
J Immunol; 1995 Aug; 155(4):1994-2004. PubMed ID: 7636250
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]