BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

463 related articles for article (PubMed ID: 19286667)

  • 1. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.
    Sugiyama T; Levy BD; Michel T
    J Biol Chem; 2009 May; 284(19):12691-700. PubMed ID: 19286667
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
    Crabtree MJ; Tatham AL; Hale AB; Alp NJ; Channon KM
    J Biol Chem; 2009 Oct; 284(41):28128-28136. PubMed ID: 19666465
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.
    Schmidt K; Kolesnik B; Gorren AC; Werner ER; Mayer B
    Biochem Pharmacol; 2014 Aug; 90(3):246-53. PubMed ID: 24863258
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
    Wang S; Xu J; Song P; Wu Y; Zhang J; Chul Choi H; Zou MH
    Hypertension; 2008 Sep; 52(3):484-90. PubMed ID: 18645049
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
    Crabtree MJ; Hale AB; Channon KM
    Free Radic Biol Med; 2011 Jun; 50(11):1639-46. PubMed ID: 21402147
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
    Crabtree MJ; Tatham AL; Al-Wakeel Y; Warrick N; Hale AB; Cai S; Channon KM; Alp NJ
    J Biol Chem; 2009 Jan; 284(2):1136-44. PubMed ID: 19011239
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926.
    Zhou ZW; Xie XL; Zhou SF; Li CG
    Eur J Pharmacol; 2012 Dec; 697(1-3):97-105. PubMed ID: 23063542
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.
    Cai Z; Lu Q; Ding Y; Wang Q; Xiao L; Song P; Zou MH
    Arterioscler Thromb Vasc Biol; 2015 Nov; 35(11):2366-73. PubMed ID: 26381869
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
    Crabtree MJ; Channon KM
    Nitric Oxide; 2011 Aug; 25(2):81-8. PubMed ID: 21550412
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
    Chuaiphichai S; Crabtree MJ; Mcneill E; Hale AB; Trelfa L; Channon KM; Douglas G
    Br J Pharmacol; 2017 Apr; 174(8):657-671. PubMed ID: 28128438
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase.
    Chalupsky K; Kračun D; Kanchev I; Bertram K; Görlach A
    Antioxid Redox Signal; 2015 Nov; 23(14):1076-91. PubMed ID: 26414244
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.
    Shimizu S; Shiota K; Yamamoto S; Miyasaka Y; Ishii M; Watabe T; Nishida M; Mori Y; Yamamoto T; Kiuchi Y
    Free Radic Biol Med; 2003 May; 34(10):1343-52. PubMed ID: 12726922
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
    Chuaiphichai S; McNeill E; Douglas G; Crabtree MJ; Bendall JK; Hale AB; Alp NJ; Channon KM
    Hypertension; 2014 Sep; 64(3):530-40. PubMed ID: 24777984
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways.
    Sugiyama T; Michel T
    Am J Physiol Heart Circ Physiol; 2010 Jan; 298(1):H194-201. PubMed ID: 19897710
    [TBL] [Abstract][Full Text] [Related]  

  • 15. GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
    Cai S; Alp NJ; McDonald D; Smith I; Kay J; Canevari L; Heales S; Channon KM
    Cardiovasc Res; 2002 Sep; 55(4):838-49. PubMed ID: 12176133
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
    Cai S; Khoo J; Channon KM
    Cardiovasc Res; 2005 Mar; 65(4):823-31. PubMed ID: 15721862
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I.
    Santhanam AV; d'Uscio LV; Katusic ZS
    Brain Res; 2015 Nov; 1625():198-205. PubMed ID: 26343845
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase.
    Abdelghany TM; Ismail RS; Mansoor FA; Zweier JR; Lowe F; Zweier JL
    Nitric Oxide; 2018 Jun; 76():113-121. PubMed ID: 29524646
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.
    Bailey J; Shaw A; Fischer R; Ryan BJ; Kessler BM; McCullagh J; Wade-Martins R; Channon KM; Crabtree MJ
    Free Radic Biol Med; 2017 Mar; 104():214-225. PubMed ID: 28104455
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CR6-interacting factor 1 deficiency reduces endothelial nitric oxide synthase activity by inhibiting biosynthesis of tetrahydrobiopterin.
    Lee I; Kim S; Nagar H; Choi SJ; Jeon BH; Piao S; Kim CS
    Sci Rep; 2020 Jan; 10(1):842. PubMed ID: 31964986
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.