BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

233 related articles for article (PubMed ID: 19328188)

  • 1. Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain.
    Liao G; Cheung S; Galeano J; Ji AX; Qin Q; Bi X
    Brain Res; 2009 May; 1270():140-51. PubMed ID: 19328188
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain.
    Liao G; Yao Y; Liu J; Yu Z; Cheung S; Xie A; Liang X; Bi X
    Am J Pathol; 2007 Sep; 171(3):962-75. PubMed ID: 17631520
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice.
    Ashikawa H; Mogi H; Honda T; Nakamura H; Murayama T
    Eur J Pharmacol; 2021 Apr; 896():173907. PubMed ID: 33503462
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice.
    Ahmad I; Lope-Piedrafita S; Bi X; Hicks C; Yao Y; Yu C; Chaitkin E; Howison CM; Weberg L; Trouard TP; Erickson RP
    J Neurosci Res; 2005 Dec; 82(6):811-21. PubMed ID: 16273542
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Normalization of cholesterol homeostasis by 2-hydroxypropyl-β-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice.
    Peake KB; Vance JE
    J Biol Chem; 2012 Mar; 287(12):9290-8. PubMed ID: 22277650
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression.
    Davidson CD; Ali NF; Micsenyi MC; Stephney G; Renault S; Dobrenis K; Ory DS; Vanier MT; Walkley SU
    PLoS One; 2009 Sep; 4(9):e6951. PubMed ID: 19750228
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease.
    Mellon SH; Gong W; Schonemann MD
    Brain Res Rev; 2008 Mar; 57(2):410-20. PubMed ID: 17629950
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1: a mouse model of Niemann-Pick type C1 disease.
    Maass F; Petersen J; Hovakimyan M; Schmitt O; Witt M; Hawlitschka A; Lukas J; Rolfs A; Wree A
    J Neurosci Res; 2015 Mar; 93(3):433-42. PubMed ID: 25400034
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.
    Ilnytska O; Lai K; Gorshkov K; Schultz ML; Tran BN; Jeziorek M; Kunkel TJ; Azaria RD; McLoughlin HS; Waghalter M; Xu Y; Schlame M; Altan-Bonnet N; Zheng W; Lieberman AP; Dobrowolski R; Storch J
    J Biol Chem; 2021 Jul; 297(1):100813. PubMed ID: 34023384
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function.
    Lopez AM; Terpack SJ; Posey KS; Liu B; Ramirez CM; Turley SD
    Clin Exp Pharmacol Physiol; 2014 Oct; 41(10):780-7. PubMed ID: 25115571
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability.
    Meske V; Erz J; Priesnitz T; Ohm TG
    Neurobiol Dis; 2014 Apr; 64():88-97. PubMed ID: 24412309
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.
    Zampieri S; Mellon SH; Butters TD; Nevyjel M; Covey DF; Bembi B; Dardis A
    J Cell Mol Med; 2009 Sep; 13(9B):3786-96. PubMed ID: 18774957
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacologic Treatment Assigned for Niemann Pick Type C1 Disease Partly Changes Behavioral Traits in Wild-Type Mice.
    Schlegel V; Thieme M; Holzmann C; Witt M; Grittner U; Rolfs A; Wree A
    Int J Mol Sci; 2016 Nov; 17(11):. PubMed ID: 27834854
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Corneal alterations during combined therapy with cyclodextrin/allopregnanolone and miglustat in a knock-out mouse model of NPC1 disease.
    Hovakimyan M; Petersen J; Maass F; Reichard M; Witt M; Lukas J; Stachs O; Guthoff R; Rolfs A; Wree A
    PLoS One; 2011; 6(12):e28418. PubMed ID: 22163015
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.
    Ramirez CM; Liu B; Taylor AM; Repa JJ; Burns DK; Weinberg AG; Turley SD; Dietschy JM
    Pediatr Res; 2010 Oct; 68(4):309-15. PubMed ID: 20581737
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.
    Colombo A; Dinkel L; Müller SA; Sebastian Monasor L; Schifferer M; Cantuti-Castelvetri L; König J; Vidatic L; Bremova-Ertl T; Lieberman AP; Hecimovic S; Simons M; Lichtenthaler SF; Strupp M; Schneider SA; Tahirovic S
    Nat Commun; 2021 Feb; 12(1):1158. PubMed ID: 33627648
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Astrocyte-only Npc1 reduces neuronal cholesterol and triples life span of Npc1-/- mice.
    Zhang M; Strnatka D; Donohue C; Hallows JL; Vincent I; Erickson RP
    J Neurosci Res; 2008 Oct; 86(13):2848-56. PubMed ID: 18500759
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice.
    Amritraj A; Peake K; Kodam A; Salio C; Merighi A; Vance JE; Kar S
    Am J Pathol; 2009 Dec; 175(6):2540-56. PubMed ID: 19893049
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evaluation of Two Liver Treatment Strategies in a Mouse Model of Niemann-Pick-Disease Type C1.
    Ebner L; Gläser A; Bräuer A; Witt M; Wree A; Rolfs A; Frank M; Vollmar B; Kuhla A
    Int J Mol Sci; 2018 Mar; 19(4):. PubMed ID: 29587349
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C.
    Chen G; Li HM; Chen YR; Gu XS; Duan S
    Glia; 2007 Nov; 55(15):1509-18. PubMed ID: 17705200
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.