105 related articles for article (PubMed ID: 19329309)
1. Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
Hopper DW; Vera MD; How D; Sabatini J; Xiang JS; Ipek M; Thomason J; Hu Y; Feyfant E; Wang Q; Georgiadis KE; Reifenberg E; Sheldon RT; Keohan CC; Majumdar MK; Morris EA; Skotnicki J; Sum PE
Bioorg Med Chem Lett; 2009 May; 19(9):2487-91. PubMed ID: 19329309
[TBL] [Abstract][Full Text] [Related]
2. Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.
Hu Y; Xing L; Thomason JR; Xiang J; Ipek M; Guler S; Li H; Sabatini J; Chockalingam P; Reifenberg E; Sheldon R; Morris EA; Georgiadis KE; Tam S
Bioorg Med Chem Lett; 2011 Nov; 21(22):6800-3. PubMed ID: 21982494
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.
Xiang JS; Hu Y; Rush TS; Thomason JR; Ipek M; Sum PE; Abrous L; Sabatini JJ; Georgiadis K; Reifenberg E; Majumdar M; Morris EA; Tam S
Bioorg Med Chem Lett; 2006 Jan; 16(2):311-6. PubMed ID: 16275085
[TBL] [Abstract][Full Text] [Related]
4. Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
Nuti E; Santamaria S; Casalini F; Yamamoto K; Marinelli L; La Pietra V; Novellino E; Orlandini E; Nencetti S; Marini AM; Salerno S; Taliani S; Da Settimo F; Nagase H; Rossello A
Eur J Med Chem; 2013 Apr; 62():379-94. PubMed ID: 23376997
[TBL] [Abstract][Full Text] [Related]
5. Aggrecanase and aggrecan degradation in osteoarthritis: a review.
Huang K; Wu LD
J Int Med Res; 2008; 36(6):1149-60. PubMed ID: 19094423
[TBL] [Abstract][Full Text] [Related]
6. N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).
Gilbert AM; Bursavich MG; Lombardi S; Georgiadis KE; Reifenberg E; Flannery CR; Morris EA
Bioorg Med Chem Lett; 2008 Dec; 18(24):6454-7. PubMed ID: 18974001
[TBL] [Abstract][Full Text] [Related]
7. Suppression of aggrecanase: a novel protective mechanism of dehydroepiandrosterone in osteoarthritis?
Huang K; Wu LD
Mol Biol Rep; 2010 Mar; 37(3):1241-5. PubMed ID: 19277895
[TBL] [Abstract][Full Text] [Related]
8. Computational approaches to improve aggrecanase-1 inhibitory activity of (4-keto) phenoxy) methyl biphenyl-4-sulfonamide: group based QSAR and docking studies.
Sivakumar PM; Selvaraj NV; Ramesh G; Mohanapriya J; Prabhawathi V; Doble M
Med Chem; 2012 Jul; 8(4):673-82. PubMed ID: 22548335
[TBL] [Abstract][Full Text] [Related]
9. Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
Durham TB; Klimkowski VJ; Rito CJ; Marimuthu J; Toth JL; Liu C; Durbin JD; Stout SL; Adams L; Swearingen C; Lin C; Chambers MG; Thirunavukkarasu K; Wiley MR
J Med Chem; 2014 Dec; 57(24):10476-85. PubMed ID: 25415648
[TBL] [Abstract][Full Text] [Related]
10. The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.
De Savi C; Pape A; Cumming JG; Ting A; Smith PD; Burrows JN; Mills M; Davies C; Lamont S; Milne D; Cook C; Moore P; Sawyer Y; Gerhardt S
Bioorg Med Chem Lett; 2011 Mar; 21(5):1376-81. PubMed ID: 21300546
[TBL] [Abstract][Full Text] [Related]
11. Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Dancevic CM; McCulloch DR
Arthritis Res Ther; 2014; 16(5):429. PubMed ID: 25606593
[TBL] [Abstract][Full Text] [Related]
12. Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo.
Madsen SH; Sumer EU; Bay-Jensen AC; Sondergaard BC; Qvist P; Karsdal MA
Biomarkers; 2010 May; 15(3):266-76. PubMed ID: 20039789
[TBL] [Abstract][Full Text] [Related]
13. Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
De Savi C; Pape A; Sawyer Y; Milne D; Davies C; Cumming JG; Ting A; Lamont S; Smith PD; Tart J; Page K; Moore P
Bioorg Med Chem Lett; 2011 Jun; 21(11):3301-6. PubMed ID: 21536437
[TBL] [Abstract][Full Text] [Related]
14. The cleavage of biglycan by aggrecanases.
Melching LI; Fisher WD; Lee ER; Mort JS; Roughley PJ
Osteoarthritis Cartilage; 2006 Nov; 14(11):1147-54. PubMed ID: 16806997
[TBL] [Abstract][Full Text] [Related]
15. [Aggrecanases and osteoarthritis].
Li C; Cao YP; Guan ZP; Huang de Y; Ge ZG
Beijing Da Xue Xue Bao Yi Xue Ban; 2009 Oct; 41(5):611-2. PubMed ID: 19829688
[TBL] [Abstract][Full Text] [Related]
16. Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.
Troeberg L; Fushimi K; Khokha R; Emonard H; Ghosh P; Nagase H
FASEB J; 2008 Oct; 22(10):3515-24. PubMed ID: 18632849
[TBL] [Abstract][Full Text] [Related]
17. Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.
Takizawa M; Yatabe T; Okada A; Chijiiwa M; Mochizuki S; Ghosh P; Okada Y
FEBS Lett; 2008 Aug; 582(19):2945-9. PubMed ID: 18671975
[TBL] [Abstract][Full Text] [Related]
18. In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage.
Steinmeyer J; Kordelle J; Stürz H
J Orthop Res; 2010 Jun; 28(6):828-33. PubMed ID: 20069635
[TBL] [Abstract][Full Text] [Related]
19. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
Tortorella MD; Malfait AM; Deccico C; Arner E
Osteoarthritis Cartilage; 2001 Aug; 9(6):539-52. PubMed ID: 11520168
[TBL] [Abstract][Full Text] [Related]
20. A microplate assay for the screening of ADAMTS-4 inhibitors.
Thomas M; Sabatini M; Bensaude F; Mignard B; Ortuno JC; Caron I; Boutin JA; Ferry G
Matrix Biol; 2006 May; 25(4):261-7. PubMed ID: 16442274
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
