BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

211 related articles for article (PubMed ID: 19332084)

  • 1. An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells.
    Noor F; Niklas J; Müller-Vieira U; Heinzle E
    Toxicol Appl Pharmacol; 2009 Jun; 237(2):221-31. PubMed ID: 19332084
    [TBL] [Abstract][Full Text] [Related]  

  • 2. High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements.
    Beckers S; Noor F; Müller-Vieira U; Mayer M; Strigun A; Heinzle E
    Toxicol In Vitro; 2010 Mar; 24(2):686-94. PubMed ID: 19427895
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.
    O'Brien PJ; Irwin W; Diaz D; Howard-Cofield E; Krejsa CM; Slaughter MR; Gao B; Kaludercic N; Angeline A; Bernardi P; Brain P; Hougham C
    Arch Toxicol; 2006 Sep; 80(9):580-604. PubMed ID: 16598496
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vitro metabolism and toxicity assessment of toxin T-514 (Peroxisomicine A1) of Karwinskia humboldtiana in microsomes and primary cultured hepatocytes.
    Gómez-Silva M; Garza-Ocañas L; Waksman N; Rivas V; Piñeyro-López A
    Toxicol In Vitro; 2005 Feb; 19(1):47-53. PubMed ID: 15582355
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes.
    Nadanaciva S; Aleo MD; Strock CJ; Stedman DB; Wang H; Will Y
    Toxicol Appl Pharmacol; 2013 Oct; 272(2):272-80. PubMed ID: 23811329
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytotoxic effects of 109 reference compounds on rat H4IIE and human HepG2 hepatocytes. III: Mechanistic assays on oxygen consumption with MitoXpress and NAD(P)H production with Alamar Blue™.
    Schoonen WG; Stevenson JC; Westerink WM; Horbach GJ
    Toxicol In Vitro; 2012 Apr; 26(3):511-25. PubMed ID: 22261204
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes.
    Lauer B; Tuschl G; Kling M; Mueller SO
    Chem Biol Interact; 2009 Apr; 179(1):17-24. PubMed ID: 19022234
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1.
    Li AP
    Chem Biol Interact; 2009 Apr; 179(1):4-8. PubMed ID: 18950609
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.
    Niklas J; Noor F; Heinzle E
    Toxicol Appl Pharmacol; 2009 Nov; 240(3):327-36. PubMed ID: 19607853
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of the Vitotox and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development.
    Westerink WM; Stevenson JC; Lauwers A; Griffioen G; Horbach GJ; Schoonen WG
    Mutat Res; 2009 May; 676(1-2):113-30. PubMed ID: 19393335
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I mechanistic assays on ROS, glutathione depletion and calcein uptake.
    Schoonen WG; Westerink WM; de Roos JA; Débiton E
    Toxicol In Vitro; 2005 Jun; 19(4):505-16. PubMed ID: 15826808
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity.
    Otto M; Hansen SH; Dalgaard L; Dubois J; Badolo L
    Cell Biol Toxicol; 2008 Jan; 24(1):87-99. PubMed ID: 17549590
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach.
    Ebbels TM; Keun HC; Beckonert OP; Bollard ME; Lindon JC; Holmes E; Nicholson JK
    J Proteome Res; 2007 Nov; 6(11):4407-22. PubMed ID: 17915905
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Relationship between in vitro phospholipidosis assay using HepG2 cells and 2-week toxicity studies in rats.
    Miyamoto S; Matsumoto A; Mori I; Horinouchi A
    Toxicol Mech Methods; 2009 Oct; 19(8):477-85. PubMed ID: 19793005
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Species-specific toxicity of troglitazone on rats and human by gel entrapped hepatocytes.
    Shen C; Meng Q; Zhang G
    Toxicol Appl Pharmacol; 2012 Jan; 258(1):19-25. PubMed ID: 22085495
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro cytotoxicity assay to evaluate the toxicity of an electrophilic reactive metabolite using glutathione-depleted rat primary cultured hepatocytes.
    Fujimoto K; Kishino H; Yamoto T; Manabe S; Sanbuissho A
    Chem Biol Interact; 2010 Dec; 188(3):404-11. PubMed ID: 20846519
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of in vitro protein biomarkers of idiosyncratic liver toxicity.
    Gao J; Ann Garulacan L; Storm SM; Hefta SA; Opiteck GJ; Lin JH; Moulin F; Dambach DM
    Toxicol In Vitro; 2004 Aug; 18(4):533-41. PubMed ID: 15130611
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Validation of a high-throughput in vitro alkaline elution/rat hepatocyte assay for DNA damage.
    Gealy R; Wright-Bourque JL; Kraynak AR; McKelvey TW; Barnum JE; Storer RD
    Mutat Res; 2007 Apr; 629(1):49-63. PubMed ID: 17306613
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A robust high-throughput sandwich cell-based drug screening platform.
    Zhang S; Tong W; Zheng B; Susanto TA; Xia L; Zhang C; Ananthanarayanan A; Tuo X; Sakban RB; Jia R; Iliescu C; Chai KH; McMillian M; Shen S; Leo H; Yu H
    Biomaterials; 2011 Feb; 32(4):1229-41. PubMed ID: 20971505
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evaluation of a carp primary hepatocyte culture system for screening chemicals for oestrogenic activity.
    Bickley LK; Lange A; Winter MJ; Tyler CR
    Aquat Toxicol; 2009 Sep; 94(3):195-203. PubMed ID: 19695720
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.