BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

550 related articles for article (PubMed ID: 19334076)

  • 1. Sustained effects of nonallele-specific Huntingtin silencing.
    Drouet V; Perrin V; Hassig R; Dufour N; Auregan G; Alves S; Bonvento G; Brouillet E; Luthi-Carter R; Hantraye P; Déglon N
    Ann Neurol; 2009 Mar; 65(3):276-85. PubMed ID: 19334076
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.
    Boudreau RL; McBride JL; Martins I; Shen S; Xing Y; Carter BJ; Davidson BL
    Mol Ther; 2009 Jun; 17(6):1053-63. PubMed ID: 19240687
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.
    Stiles DK; Zhang Z; Ge P; Nelson B; Grondin R; Ai Y; Hardy P; Nelson PT; Guzaev AP; Butt MT; Charisse K; Kosovrasti V; Tchangov L; Meys M; Maier M; Nechev L; Manoharan M; Kaemmerer WF; Gwost D; Stewart GR; Gash DM; Sah DW
    Exp Neurol; 2012 Jan; 233(1):463-71. PubMed ID: 22119622
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum.
    Grondin R; Kaytor MD; Ai Y; Nelson PT; Thakker DR; Heisel J; Weatherspoon MR; Blum JL; Burright EN; Zhang Z; Kaemmerer WF
    Brain; 2012 Apr; 135(Pt 4):1197-209. PubMed ID: 22252996
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cellular Analysis of Silencing the Huntington's Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice.
    Keeler AM; Sapp E; Chase K; Sottosanti E; Danielson E; Pfister E; Stoica L; DiFiglia M; Aronin N; Sena-Esteves M
    J Huntingtons Dis; 2016 Oct; 5(3):239-248. PubMed ID: 27689620
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells.
    Drouet V; Ruiz M; Zala D; Feyeux M; Auregan G; Cambon K; Troquier L; Carpentier J; Aubert S; Merienne N; Bourgois-Rocha F; Hassig R; Rey M; Dufour N; Saudou F; Perrier AL; Hantraye P; Déglon N
    PLoS One; 2014; 9(6):e99341. PubMed ID: 24926995
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.
    van Bilsen PH; Jaspers L; Lombardi MS; Odekerken JC; Burright EN; Kaemmerer WF
    Hum Gene Ther; 2008 Jul; 19(7):710-9. PubMed ID: 18549309
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.
    de Almeida LP; Ross CA; Zala D; Aebischer P; Déglon N
    J Neurosci; 2002 May; 22(9):3473-83. PubMed ID: 11978824
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum.
    Régulier E; Trottier Y; Perrin V; Aebischer P; Déglon N
    Hum Mol Genet; 2003 Nov; 12(21):2827-36. PubMed ID: 12952868
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.
    Francelle L; Galvan L; Gaillard MC; Petit F; Bernay B; Guillermier M; Bonvento G; Dufour N; Elalouf JM; Hantraye P; Déglon N; de Chaldée M; Brouillet E
    Neurobiol Aging; 2015 Mar; 36(3):1601.e7-16. PubMed ID: 25619660
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
    Hermel E; Gafni J; Propp SS; Leavitt BR; Wellington CL; Young JE; Hackam AS; Logvinova AV; Peel AL; Chen SF; Hook V; Singaraja R; Krajewski S; Goldsmith PC; Ellerby HM; Hayden MR; Bredesen DE; Ellerby LM
    Cell Death Differ; 2004 Apr; 11(4):424-38. PubMed ID: 14713958
    [TBL] [Abstract][Full Text] [Related]  

  • 12. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.
    Harper SQ; Staber PD; He X; Eliason SL; Martins IH; Mao Q; Yang L; Kotin RM; Paulson HL; Davidson BL
    Proc Natl Acad Sci U S A; 2005 Apr; 102(16):5820-5. PubMed ID: 15811941
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.
    Van Raamsdonk JM; Pearson J; Murphy Z; Hayden MR; Leavitt BR
    BMC Neurosci; 2006 Dec; 7():80. PubMed ID: 17147801
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.
    Wang YL; Liu W; Wada E; Murata M; Wada K; Kanazawa I
    Neurosci Res; 2005 Nov; 53(3):241-9. PubMed ID: 16095740
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
    Huang B; Schiefer J; Sass C; Kosinski CM; Kochanek S
    J Gene Med; 2008 Mar; 10(3):269-79. PubMed ID: 18067195
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High-capacity adenoviral vector-mediated reduction of huntingtin aggregate load in vitro and in vivo.
    Huang B; Schiefer J; Sass C; Landwehrmeyer GB; Kosinski CM; Kochanek S
    Hum Gene Ther; 2007 Apr; 18(4):303-11. PubMed ID: 17472569
    [TBL] [Abstract][Full Text] [Related]  

  • 17. AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease.
    Franich NR; Fitzsimons HL; Fong DM; Klugmann M; During MJ; Young D
    Mol Ther; 2008 May; 16(5):947-56. PubMed ID: 18388917
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse.
    Brown TB; Bogush AI; Ehrlich ME
    Hum Mol Genet; 2008 Oct; 17(20):3095-104. PubMed ID: 18632688
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.
    Martin E; Betuing S; Pagès C; Cambon K; Auregan G; Deglon N; Roze E; Caboche J
    Hum Mol Genet; 2011 Jun; 20(12):2422-34. PubMed ID: 21493629
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
    Inagaki R; Tagawa K; Qi ML; Enokido Y; Ito H; Tamura T; Shimizu S; Oyanagi K; Arai N; Kanazawa I; Wanker EE; Okazawa H
    Eur J Neurosci; 2008 Jul; 28(1):30-40. PubMed ID: 18662332
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 28.