BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

169 related articles for article (PubMed ID: 19364812)

  • 1. Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target.
    Yan C; Shieh B; Reigan P; Zhang Z; Colucci MA; Chilloux A; Newsome JJ; Siegel D; Chan D; Moody CJ; Ross D
    Mol Pharmacol; 2009 Jul; 76(1):163-72. PubMed ID: 19364812
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.
    Dehn DL; Siegel D; Zafar KS; Reigan P; Swann E; Moody CJ; Ross D
    Mol Cancer Ther; 2006 Jul; 5(7):1702-9. PubMed ID: 16891456
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling.
    Yan C; Siegel D; Newsome J; Chilloux A; Moody CJ; Ross D
    Mol Pharmacol; 2012 Mar; 81(3):401-10. PubMed ID: 22147753
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
    Reigan P; Colucci MA; Siegel D; Chilloux A; Moody CJ; Ross D
    Biochemistry; 2007 May; 46(20):5941-50. PubMed ID: 17455910
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.
    Abdullah NA; Inman M; Moody CJ; Storr SJ; Martin SG
    Invest New Drugs; 2021 Oct; 39(5):1232-1241. PubMed ID: 33768386
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells.
    Inman M; Visconti A; Yan C; Siegel D; Ross D; Moody CJ
    Org Biomol Chem; 2014 Jul; 12(27):4848-61. PubMed ID: 24848343
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase.
    Powis G; Wipf P; Lynch SM; Birmingham A; Kirkpatrick DL
    Mol Cancer Ther; 2006 Mar; 5(3):630-6. PubMed ID: 16546977
    [TBL] [Abstract][Full Text] [Related]  

  • 8. KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer.
    Casique-Aguirre D; Briseño-Díaz P; García-Gutiérrez P; la Rosa CHG; Quintero-Barceinas RS; Rojo-Domínguez A; Vergara I; Medina LA; Correa-Basurto J; Bello M; Hernández-Rivas R; Del RocioThompson-Bonilla M; Vargas M
    BMC Cancer; 2018 Dec; 18(1):1299. PubMed ID: 30594165
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy.
    Qian J; Xu Z; Meng C; Liu J; Hsu PL; Li Y; Zhu W; Yang Y; Morris-Natschke SL; Lee KH; Zhang Y; Ling Y
    Eur J Med Chem; 2020 Oct; 204():112610. PubMed ID: 32736231
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Apoptotic activity and antitumor efficacy of PEGylated TNF-related apoptosis-inducing ligand (TRAIL) in a Mia Paca-2 cell-xenografted mouse model.
    Byeon HJ; Choi SH; Choi JS; Kim TH; Lee ES; Lee KC; Youn YS
    Biomed Pharmacother; 2014 Feb; 68(1):65-9. PubMed ID: 24268811
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.
    Wang X; Gao M; Zhang J; Ma Y; Qu W; Liang J; Wu H; Wen H
    Redox Biol; 2019 Jun; 24():101153. PubMed ID: 30909158
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells.
    Kumar A; Singh B; Mahajan G; Sharma PR; Bharate SB; Mintoo MJ; Mondhe DM
    Tumour Biol; 2016 Oct; 37(10):13121-13136. PubMed ID: 27449046
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Diaryl chalcogenides as selective inhibitors of thioredoxin reductase and potential antitumor agents.
    Engman L; Cotgreave I; Angulo M; Taylor CW; Paine-Murrieta GD; Powis G
    Anticancer Res; 1997; 17(6D):4599-605. PubMed ID: 9494575
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.
    Liu J; Mu C; Yue W; Li J; Ma B; Zhao L; Liu L; Chen Q; Yan C; Liu H; Hao X; Zhu Y
    Free Radic Biol Med; 2013 Oct; 63():485-94. PubMed ID: 23732520
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity.
    Krasavin M; Sharonova T; Sharoyko V; Zhukovsky D; Kalinin S; Žalubovskis R; Tennikova T; Supuran CT
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):665-671. PubMed ID: 32131646
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.
    Yan C; Dufour M; Siegel D; Reigan P; Gomez J; Shieh B; Moody CJ; Ross D
    Biochemistry; 2011 Aug; 50(31):6678-88. PubMed ID: 21718050
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cationic and Neutral N-Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI-60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation.
    Zhang C; Hemmert C; Gornitzka H; Cuvillier O; Zhang M; Sun RW
    ChemMedChem; 2018 Jun; 13(12):1218-1229. PubMed ID: 29603648
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ruthenium(II) salicylate complexes inducing ROS-mediated apoptosis by targeting thioredoxin reductase.
    Chen JC; Zhang Y; Jie XM; She J; Dongye GZ; Zhong Y; Deng YY; Wang J; Guo BY; Chen LM
    J Inorg Biochem; 2019 Apr; 193():112-123. PubMed ID: 30711557
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302.
    Li S; Zhang J; Li J; Chen D; Matteucci M; Curd J; Duan JX
    Biol Trace Elem Res; 2010 Sep; 136(3):294-301. PubMed ID: 19838642
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity.
    Guzmán EA; Xu Q; Pitts TP; Mitsuhashi KO; Baker C; Linley PA; Oestreicher J; Tendyke K; Winder PL; Suh EM; Wright AE
    Int J Cancer; 2016 Nov; 139(9):2116-26. PubMed ID: 27376928
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.