BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

389 related articles for article (PubMed ID: 19372225)

  • 1. Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs.
    Yuan H; Li N; Lai Y
    Drug Metab Dispos; 2009 Jul; 37(7):1443-7. PubMed ID: 19372225
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: illustration of intraluminal supersaturation.
    Brouwers J; Tack J; Augustijns P
    Int J Pharm; 2007 May; 336(2):302-9. PubMed ID: 17207947
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics.
    Yan Z; Sun J; Chang Y; Liu Y; Fu Q; Xu Y; Sun Y; Pu X; Zhang Y; Jing Y; Yin S; Zhu M; Wang Y; He Z
    Mol Pharm; 2011 Apr; 8(2):319-29. PubMed ID: 21280612
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.
    Sohma Y; Hayashi Y; Ito T; Matsumoto H; Kimura T; Kiso Y
    J Med Chem; 2003 Sep; 46(19):4124-35. PubMed ID: 12954064
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations.
    Subramanian M; Paruchury S; Singh Gautam S; Pratap Singh S; Arla R; Pahwa S; Jana S; Katnapally P; Yoganand V; Lakshmaiah B; Mazumder Tagore D; Ghosh K; Marathe P; Mandlekar S
    Drug Metab Dispos; 2013 Jul; 41(7):1425-32. PubMed ID: 23633529
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Absorption of ester prodrugs in Caco-2 and rat intestine models.
    He X; Sugawara M; Takekuma Y; Miyazaki K
    Antimicrob Agents Chemother; 2004 Jul; 48(7):2604-9. PubMed ID: 15215116
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In-vitro corneal permeation of cannabinoids and their water-soluble phosphate ester prodrugs.
    Juntunen J; Järvinen T; Niemi R
    J Pharm Pharmacol; 2005 Sep; 57(9):1153-7. PubMed ID: 16105235
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro evaluation of dendrimer prodrugs for oral drug delivery.
    Najlah M; Freeman S; Attwood D; D'Emanuele A
    Int J Pharm; 2007 May; 336(1):183-90. PubMed ID: 17188439
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity.
    Ohura K; Sakamoto H; Ninomiya S; Imai T
    Drug Metab Dispos; 2010 Feb; 38(2):323-31. PubMed ID: 19923255
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Enzyme-mediated precipitation of parent drugs from their phosphate prodrugs.
    Heimbach T; Oh DM; Li LY; Rodríguez-Hornedo N; Garcia G; Fleisher D
    Int J Pharm; 2003 Aug; 261(1-2):81-92. PubMed ID: 12878397
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone.
    Mäntylä A; Garnier T; Rautio J; Nevalainen T; Vepsälainen J; Koskinen A; Croft SL; Järvinen T
    J Med Chem; 2004 Jan; 47(1):188-95. PubMed ID: 14695832
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mathematical models to calculate fosphenytoin concentrations in the presence of phenytoin using phenytoin immunoassays and alkaline phosphatase.
    Dasgupta A; Handy BC; Datta P
    Am J Clin Pathol; 2000 Jan; 113(1):87-92. PubMed ID: 10631861
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.
    Lorenzi PL; Landowski CP; Song X; Borysko KZ; Breitenbach JM; Kim JS; Hilfinger JM; Townsend LB; Drach JC; Amidon GL
    J Pharmacol Exp Ther; 2005 Aug; 314(2):883-90. PubMed ID: 15901797
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients.
    Aoyama T; Hirata K; Hirata R; Yamazaki H; Yamamoto Y; Hayashi H; Matsumoto Y
    J Clin Pharm Ther; 2012 Jun; 37(3):356-63. PubMed ID: 21883330
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method.
    Antunes Viegas D; Rodrigues M; Francisco J; Falcão A; Alves G; Santos AO
    Eur J Pharm Sci; 2016 Jun; 89():61-72. PubMed ID: 27106504
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Stereoselective and concentration-dependent polarized epithelial permeability of a series of phosphoramidate triester prodrugs of d4T: an in vitro study in Caco-2 and Madin-Darby canine kidney cell monolayers.
    Siccardi D; Kandalaft LE; Gumbleton M; McGuigan C
    J Pharmacol Exp Ther; 2003 Dec; 307(3):1112-9. PubMed ID: 14557377
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Absorption rate limit considerations for oral phosphate prodrugs.
    Heimbach T; Oh DM; Li LY; Forsberg M; Savolainen J; Leppänen J; Matsunaga Y; Flynn G; Fleisher D
    Pharm Res; 2003 Jun; 20(6):848-56. PubMed ID: 12817887
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs.
    Pettit GR; Lippert JW
    Anticancer Drug Des; 2000 Jun; 15(3):203-16. PubMed ID: 11049088
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.
    Okudaira N; Tatebayashi T; Speirs GC; Komiya I; Sugiyama Y
    J Pharmacol Exp Ther; 2000 Aug; 294(2):580-7. PubMed ID: 10900235
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol.
    Kumpulainen H; Järvinen T; Mannila A; Leppänen J; Nevalainen T; Mäntylä A; Vepsäläinen J; Rautio J
    Eur J Pharm Sci; 2008 Jul; 34(2-3):110-7. PubMed ID: 18403185
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.