135 related articles for article (PubMed ID: 19376115)
1. An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
Suzuki Y; Ohta K; Itoh M; Sakoh-Sumitomo Y; Mitsuda T; Ueda M; Hayakawa-Yano Y; Li S; Hida Y; Inuzuka T; Jung YK; Nakagawa T
FEBS Lett; 2009 May; 583(9):1403-8. PubMed ID: 19376115
[TBL] [Abstract][Full Text] [Related]
2. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
3. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
[TBL] [Abstract][Full Text] [Related]
4. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
[TBL] [Abstract][Full Text] [Related]
5. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Wang J; Beher D; Nyborg AC; Shearman MS; Golde TE; Goate A
J Neurochem; 2006 Jan; 96(1):218-27. PubMed ID: 16305624
[TBL] [Abstract][Full Text] [Related]
6. Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis.
Confaloni A; Crestini A; Albani D; Piscopo P; Campeggi LM; Terreni L; Tartaglia M; Forloni G
Brain Res Mol Brain Res; 2005 May; 136(1-2):12-22. PubMed ID: 15893582
[TBL] [Abstract][Full Text] [Related]
7. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
Shiraishi H; Marutani T; Wang HQ; Maeda Y; Kurono Y; Takashima A; Araki W; Nishimura M; Yanagisawa K; Komano H
Genes Cells; 2006 Jan; 11(1):83-93. PubMed ID: 16371134
[TBL] [Abstract][Full Text] [Related]
8. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
Kaether C; Capell A; Edbauer D; Winkler E; Novak B; Steiner H; Haass C
EMBO J; 2004 Dec; 23(24):4738-48. PubMed ID: 15549135
[TBL] [Abstract][Full Text] [Related]
9. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
[TBL] [Abstract][Full Text] [Related]
10. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
Walker ES; Martinez M; Wang J; Goate A
J Neurochem; 2006 Jul; 98(1):300-9. PubMed ID: 16805816
[TBL] [Abstract][Full Text] [Related]
11. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
[TBL] [Abstract][Full Text] [Related]
12. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Prokop S; Haass C; Steiner H
J Neurochem; 2005 Jul; 94(1):57-62. PubMed ID: 15953349
[TBL] [Abstract][Full Text] [Related]
13. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
[TBL] [Abstract][Full Text] [Related]
14. Secretase inhibitors and modulators for Alzheimer's disease treatment.
Tomita T
Expert Rev Neurother; 2009 May; 9(5):661-79. PubMed ID: 19402777
[TBL] [Abstract][Full Text] [Related]
15. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
Winkler E; Hobson S; Fukumori A; Dümpelfeld B; Luebbers T; Baumann K; Haass C; Hopf C; Steiner H
Biochemistry; 2009 Feb; 48(6):1183-97. PubMed ID: 19159235
[TBL] [Abstract][Full Text] [Related]
16. p53 is regulated by and regulates members of the gamma-secretase complex.
Checler F; Dunys J; Pardossi-Piquard R; Alves da Costa C
Neurodegener Dis; 2010; 7(1-3):50-5. PubMed ID: 20160459
[TBL] [Abstract][Full Text] [Related]
17. Analysis of alteration of p75NTR processing and signalling by PS2 mutation and gamma-secretase inhibition.
Ito Y; Ishii A; Passmore AP; McIlroy SP
Neurobiol Dis; 2007 Sep; 27(3):258-64. PubMed ID: 17582777
[TBL] [Abstract][Full Text] [Related]
18. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.
Nadler Y; Alexandrovich A; Grigoriadis N; Hartmann T; Rao KS; Shohami E; Stein R
Glia; 2008 Apr; 56(5):552-67. PubMed ID: 18240300
[TBL] [Abstract][Full Text] [Related]
19. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
[TBL] [Abstract][Full Text] [Related]
20. From presenilinase to gamma-secretase, cleave to capacitate.
Xia W
Curr Alzheimer Res; 2008 Apr; 5(2):172-8. PubMed ID: 18393802
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]