BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 19384949)

  • 1. Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells.
    Fazzone W; Wilson PM; Labonte MJ; Lenz HJ; Ladner RD
    Int J Cancer; 2009 Jul; 125(2):463-73. PubMed ID: 19384949
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil.
    Matsuoka K; Tsukuda K; Suda M; Kobayashi K; Ota T; Okita A; Watanabe K; Suzuki E; Murakami M; Doihara H; Shimizu N
    Int J Oncol; 2004 Jan; 24(1):217-22. PubMed ID: 14654960
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents.
    Yawata A; Kim SR; Miyajima A; Kubo T; Ishida S; Saito Y; Nakajima Y; Katori N; Matsumoto Y; Fukuoka M; Ohno Y; Ozawa S; Sawada J
    Cancer Chemother Pharmacol; 2005 Nov; 56(5):465-72. PubMed ID: 15918040
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression.
    Noro R; Miyanaga A; Minegishi Y; Okano T; Seike M; Soeno C; Kataoka K; Matsuda K; Yoshimura A; Gemma A
    Cancer Sci; 2010 Jun; 101(6):1424-30. PubMed ID: 20384633
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cell cycle regulation of the G0/G1 transition in 5-fluorouracil-sensitive and -resistant human colon cancer cell lines.
    McGinn CJ; Pestalozzi BC; Drake JC; Glennon MC; Kunugi K; Otterson G; Allegra CJ; Johnston PG; Kinsella TJ
    Cancer J; 2000; 6(4):234-42. PubMed ID: 11038143
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
    Longley DB; Boyer J; Allen WL; Latif T; Ferguson PR; Maxwell PJ; McDermott U; Lynch M; Harkin DP; Johnston PG
    Cancer Res; 2002 May; 62(9):2644-9. PubMed ID: 11980662
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Combined modulation by leucovorin and alpha-2a interferon of fluoropyrimidine mediated growth inhibition.
    Sinnige HA; Timmer-Bosscha H; Peters GF; De Vries EG; Mulder NH
    Anticancer Res; 1993; 13(5A):1335-40. PubMed ID: 8239504
    [TBL] [Abstract][Full Text] [Related]  

  • 8. DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines.
    LaBonte MJ; Wilson PM; Fazzone W; Groshen S; Lenz HJ; Ladner RD
    BMC Med Genomics; 2009 Nov; 2():67. PubMed ID: 19948057
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chronic exposure of colorectal cancer cells in culture to fluoropyrimidine analogs induces thymidylate synthase and suppresses p53. A molecular explanation for the mechanism of 5-FU resistance.
    Subbarayan PR; Sarkar M; Nelson G; Benitez E; Singhal S; Ardalan B
    Anticancer Res; 2010 Apr; 30(4):1149-56. PubMed ID: 20530421
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
    Peters GJ; van Triest B; Backus HH; Kuiper CM; van der Wilt CL; Pinedo HM
    Eur J Cancer; 2000 May; 36(7):916-24. PubMed ID: 10785598
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells.
    Lee JH; Park JH; Jung Y; Kim JH; Jong HS; Kim TY; Bang YJ
    Mol Cancer Ther; 2006 Dec; 5(12):3085-95. PubMed ID: 17172411
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.
    Longley DB; Ferguson PR; Boyer J; Latif T; Lynch M; Maxwell P; Harkin DP; Johnston PG
    Clin Cancer Res; 2001 Nov; 7(11):3533-9. PubMed ID: 11705873
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antisense thymidylate synthase electrogene transfer to increase uptake of radiolabeled iododeoxyuridine in a murine model.
    Chi KH; Wang HE; Wang YS; Chou SL; Yu HM; Tseng YH; Hwang IM; Lui WY
    J Nucl Med; 2004 Mar; 45(3):478-84. PubMed ID: 15001691
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger.
    Berg RW; Ferguso PJ; DeMoor JM; Vincen MD; Koropatnick J
    Curr Drug Targets; 2002 Aug; 3(4):297-309. PubMed ID: 12102601
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Sequential treatment with SN-38 followed by 5-fluorouracil shows synergistic cytotoxic activity in small cell lung cancer cells.
    Takeda K; Suyama H; Igishi T; Shigeoka Y; Matsumoto S; Yamasaki A; Hashimoto K; Sumikawa T; Morita M; Ueda Y; Shimizu E
    Oncol Rep; 2008 Apr; 19(4):945-51. PubMed ID: 18357380
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.
    Chu E; Koeller DM; Johnston PG; Zinn S; Allegra CJ
    Mol Pharmacol; 1993 Apr; 43(4):527-33. PubMed ID: 8474431
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
    Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer.
    Xi Y; Nakajima G; Schmitz JC; Chu E; Ju J
    BMC Genomics; 2006 Apr; 7():68. PubMed ID: 16584549
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells.
    Yang D; Qu J; Qu X; Cao Y; Xu L; Hou K; Feng W; Liu Y
    Cancer Chemother Pharmacol; 2015 Sep; 76(3):575-86. PubMed ID: 26208739
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer.
    Nita ME; Tominaga O; Nagawa H; Tsuruo T; Muto T
    Hepatogastroenterology; 1998; 45(24):2117-22. PubMed ID: 9951876
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.