421 related articles for article (PubMed ID: 19389384)
1. Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).
Bronckaers A; Aguado L; Negri A; Camarasa MJ; Balzarini J; Pérez-Pérez MJ; Gago F; Liekens S
Biochem Pharmacol; 2009 Aug; 78(3):231-40. PubMed ID: 19389384
[TBL] [Abstract][Full Text] [Related]
2. Thymidine phosphorylase is noncompetitively inhibited by 5'-O-trityl-inosine (KIN59) and related compounds.
Liekens S; Balzarini J; Hernández AI; De Clercq E; Priego EM; Camarasa MJ; Pérez-Pérez MJ
Nucleosides Nucleotides Nucleic Acids; 2006; 25(9-11):975-80. PubMed ID: 17065049
[TBL] [Abstract][Full Text] [Related]
3. 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase.
Casanova E; Hernandez AI; Priego EM; Liekens S; Camarasa MJ; Balzarini J; Pérez-Pérez MJ
J Med Chem; 2006 Sep; 49(18):5562-70. PubMed ID: 16942029
[TBL] [Abstract][Full Text] [Related]
4. The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist.
Liekens S; Bronckaers A; Belleri M; Bugatti A; Sienaert R; Ribatti D; Nico B; Gigante A; Casanova E; Opdenakker G; Pérez-Pérez MJ; Balzarini J; Presta M
Mol Cancer Ther; 2012 Apr; 11(4):817-29. PubMed ID: 22302099
[TBL] [Abstract][Full Text] [Related]
5. [Influence of the thymidine phosphorylase (platelet-derived endothelial cell growth factor) on tumor angiogenesis. Catalytic activity of enzyme inhibitors].
Miszczak-Zaborska E; Smolarek M; Bartkowiak J
Postepy Biochem; 2010; 56(1):61-6. PubMed ID: 20499682
[TBL] [Abstract][Full Text] [Related]
6. 5'-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis.
Liekens S; Bronckaers A; Hernández AI; Priego EM; Casanova E; Camarasa MJ; Pérez-Pérez MJ; Balzarini J
Mol Pharmacol; 2006 Aug; 70(2):501-9. PubMed ID: 16675660
[TBL] [Abstract][Full Text] [Related]
7. The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action.
Liekens S; Hernández AI; Ribatti D; De Clercq E; Camarasa MJ; Pérez-Pérez MJ; Balzarini J
J Biol Chem; 2004 Jul; 279(28):29598-605. PubMed ID: 15123637
[TBL] [Abstract][Full Text] [Related]
8. The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism.
Jain HV; Rasheed R; Kalman TI
Bioorg Med Chem Lett; 2010 Mar; 20(5):1648-51. PubMed ID: 20138520
[TBL] [Abstract][Full Text] [Related]
9. Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.
Mendieta J; Martín-Santamaría S; Priego EM; Balzarini J; Camarasa MJ; Pérez-Pérez MJ; Gago F
Biochemistry; 2004 Jan; 43(2):405-14. PubMed ID: 14717594
[TBL] [Abstract][Full Text] [Related]
10. 3'-Azidothymidine in the active site of Escherichia coli thymidine phosphorylase: the peculiarity of the binding on the basis of X-ray study.
Timofeev V; Abramchik Y; Zhukhlistova N; Muravieva T; Fateev I; Esipov R; Kuranova I
Acta Crystallogr D Biol Crystallogr; 2014 Apr; 70(Pt 4):1155-65. PubMed ID: 24699659
[TBL] [Abstract][Full Text] [Related]
11. Regulation of cancer progression by inhibition of angiogenesis and induction of apoptosis.
Liekens S
Verh K Acad Geneeskd Belg; 2008; 70(3):175-91. PubMed ID: 18669159
[TBL] [Abstract][Full Text] [Related]
12. Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.
Cetinbaş N; Macauley MS; Stubbs KA; Drapala R; Vocadlo DJ
Biochemistry; 2006 Mar; 45(11):3835-44. PubMed ID: 16533067
[TBL] [Abstract][Full Text] [Related]
13. X-ray structure of the R69D phosphatidylinositol-specific phospholipase C enzyme: insight into the role of calcium and surrounding amino acids in active site geometry and catalysis.
Apiyo D; Zhao L; Tsai MD; Selby TL
Biochemistry; 2005 Aug; 44(30):9980-9. PubMed ID: 16042375
[TBL] [Abstract][Full Text] [Related]
14. Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy.
Liekens S; Bronckaers A; Pérez-Pérez MJ; Balzarini J
Biochem Pharmacol; 2007 Dec; 74(11):1555-67. PubMed ID: 17572389
[TBL] [Abstract][Full Text] [Related]
15. Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme.
Hung HC; Chien YC; Hsieh JY; Chang GG; Liu GY
Biochemistry; 2005 Sep; 44(38):12737-45. PubMed ID: 16171388
[TBL] [Abstract][Full Text] [Related]
16. Catalytic mechanism of inulinase from Arthrobacter sp. S37.
Kim KY; Nascimento AS; Golubev AM; Polikarpov I; Kim CS; Kang SI; Kim SI
Biochem Biophys Res Commun; 2008 Jul; 371(4):600-5. PubMed ID: 18395004
[TBL] [Abstract][Full Text] [Related]
17. Insights into the structural basis of substrate recognition by histidinol-phosphate aminotransferase from Corynebacterium glutamicum.
Marienhagen J; Sandalova T; Sahm H; Eggeling L; Schneider G
Acta Crystallogr D Biol Crystallogr; 2008 Jun; 64(Pt 6):675-85. PubMed ID: 18560156
[TBL] [Abstract][Full Text] [Related]
18. Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.
Hatano A; Harano A; Takigawa Y; Naramoto Y; Toda K; Nakagomi Y; Yamada H
Bioorg Med Chem; 2008 Apr; 16(7):3866-70. PubMed ID: 18272369
[TBL] [Abstract][Full Text] [Related]
19. Identification of an inhibitor binding site of poly(ADP-ribose) glycohydrolase.
Koh DW; Patel CN; Ramsinghani S; Slama JT; Oliveira MA; Jacobson MK
Biochemistry; 2003 May; 42(17):4855-63. PubMed ID: 12718526
[TBL] [Abstract][Full Text] [Related]
20. Crystallographic and functional characterization of the fluorodifen-inducible glutathione transferase from Glycine max reveals an active site topography suited for diphenylether herbicides and a novel L-site.
Axarli I; Dhavala P; Papageorgiou AC; Labrou NE
J Mol Biol; 2009 Jan; 385(3):984-1002. PubMed ID: 19014949
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
