These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 19389861)

  • 1. Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats.
    Liu X; Vilenski O; Kwan J; Apparsundaram S; Weikert R
    Drug Metab Dispos; 2009 Jul; 37(7):1548-56. PubMed ID: 19389861
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
    Huang Y; Bae SA; Zhu Z; Guo N; Roth BL; Laruelle M
    J Med Chem; 2005 Apr; 48(7):2559-70. PubMed ID: 15801845
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.
    Kulkarni SS; Grundt P; Kopajtic T; Katz JL; Newman AH
    J Med Chem; 2004 Jun; 47(13):3388-98. PubMed ID: 15189035
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain.
    Murthy V; Martin TJ; Kim S; Davies HM; Childers SR
    J Pharmacol Exp Ther; 2008 Aug; 326(2):587-95. PubMed ID: 18492949
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.
    Zou MF; Kopajtic T; Katz JL; Newman AH
    J Med Chem; 2003 Jul; 46(14):2908-16. PubMed ID: 12825932
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ex vivo assessment of binding site occupancy of monoamine reuptake inhibitors: methodology and biological significance.
    Lengyel K; Pieschl R; Strong T; Molski T; Mattson G; Lodge NJ; Li YW
    Neuropharmacology; 2008 Jul; 55(1):63-70. PubMed ID: 18538356
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
    Aluisio L; Lord B; Barbier AJ; Fraser IC; Wilson SJ; Boggs J; Dvorak LK; Letavic MA; Maryanoff BE; Carruthers NI; Bonaventure P; Lovenberg TW
    Eur J Pharmacol; 2008 Jun; 587(1-3):141-6. PubMed ID: 18499098
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters.
    Carroll FI; Blough BE; Nie Z; Kuhar MJ; Howell LL; Navarro HA
    J Med Chem; 2005 Apr; 48(8):2767-71. PubMed ID: 15828814
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
    Lomenzo SA; Rhoden JB; Izenwasser S; Wade D; Kopajtic T; Katz JL; Trudell ML
    J Med Chem; 2005 Mar; 48(5):1336-43. PubMed ID: 15743177
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives.
    Xu L; Kulkarni SS; Izenwasser S; Katz JL; Kopajtic T; Lomenzo SA; Newman AH; Trudell ML
    J Med Chem; 2004 Mar; 47(7):1676-82. PubMed ID: 15027858
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.
    Zhang S; Zhen J; Reith ME; Dutta AK
    J Med Chem; 2005 Jul; 48(15):4962-71. PubMed ID: 16033275
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.
    Zhang S; Fernandez F; Hazeldine S; Deschamps J; Zhen J; Reith ME; Dutta AK
    J Med Chem; 2006 Jul; 49(14):4239-47. PubMed ID: 16821783
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands.
    Jarkas N; Voll RJ; Williams L; Votaw JR; Owens M; Goodman MM
    J Med Chem; 2008 Jan; 51(2):271-81. PubMed ID: 18085744
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and characterization of a novel allosteric modulator (SoRI-6238) of the serotonin transporter.
    Nandi A; Dersch CM; Kulshrestha M; Ananthan S; Rothman RB
    Synapse; 2004 Sep; 53(3):176-83. PubMed ID: 15236350
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.
    Plisson C; Stehouwer JS; Voll RJ; Howell L; Votaw JR; Owens MJ; Goodman MM
    J Med Chem; 2007 Sep; 50(19):4553-60. PubMed ID: 17705359
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
    Carroll FI; Runyon SP; Abraham P; Navarro H; Kuhar MJ; Pollard GT; Howard JL
    J Med Chem; 2004 Dec; 47(25):6401-9. PubMed ID: 15566309
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters.
    Zhang S; Zhen J; Reith ME; Dutta AK
    Bioorg Med Chem; 2004 Dec; 12(23):6301-15. PubMed ID: 15519172
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat.
    Bourdet DL; Tsuruda PR; Obedencio GP; Smith JA
    J Pharmacol Exp Ther; 2012 Apr; 341(1):137-45. PubMed ID: 22235148
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethamphetamine (MDMA) under acidic conditions.
    Yamauchi Y; Izumi T; Unemura K; Uenishi Y; Nakagawa T; Kaneko S
    Neurosci Lett; 2007 Nov; 428(2-3):72-6. PubMed ID: 17949903
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.
    Chen N; Zhen J; Reith ME
    J Neurochem; 2004 May; 89(4):853-64. PubMed ID: 15140185
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.