These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 1939184)

  • 1. Mechanism of mutual activation of the tryptophan synthase alpha and beta subunits. Analysis of the reaction specificity and substrate-induced inactivation of active site and tunnel mutants of the beta subunit.
    Ahmed SA; Ruvinov SB; Kayastha AM; Miles EW
    J Biol Chem; 1991 Nov; 266(32):21548-57. PubMed ID: 1939184
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ligand-mediated changes in the tryptophan synthase indole tunnel probed by nile red fluorescence with wild type, mutant, and chemically modified enzymes.
    Ruvinov SB; Yang XJ; Parris KD; Banik U; Ahmed SA; Miles EW; Sackett DL
    J Biol Chem; 1995 Mar; 270(11):6357-69. PubMed ID: 7890774
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A novel intersubunit repair mechanism in the tryptophan synthase alpha 2 beta 2 complex. Critical role of the beta subunit lysine 167 in intersubunit communication.
    Yang XJ; Miles EW
    J Biol Chem; 1993 Oct; 268(30):22269-72. PubMed ID: 8226734
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evidence for two conformers of the beta subunit of tryptophan synthase in solution.
    Ahmed SA; Miles EW
    J Biol Chem; 1992 Nov; 267(32):23309-17. PubMed ID: 1429678
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the beta-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium.
    Brzović PS; Kayastha AM; Miles EW; Dunn MF
    Biochemistry; 1992 Feb; 31(4):1180-90. PubMed ID: 1346502
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of the functional role of a flexible loop in the alpha-subunit of tryptophan synthase from Salmonella typhimurium by rapid-scanning, stopped-flow spectroscopy and site-directed mutagenesis.
    Brzović PS; Hyde CC; Miles EW; Dunn MF
    Biochemistry; 1993 Oct; 32(39):10404-13. PubMed ID: 8399184
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Circular dichroism studies of the coenzyme environment in the active sites of mutant forms of the beta-subunit in the tryptophan synthase alpha 2 beta 2 complex.
    Kayastha AM; Sawa Y; Nagata S; Kanzaki H; Miles EW
    Indian J Biochem Biophys; 1991; 28(5-6):352-7. PubMed ID: 1812066
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Site-directed mutagenesis of the beta subunit of tryptophan synthase from Salmonella typhimurium. Role of active site glutamic acid 350.
    Kayastha AM; Sawa Y; Nagata S; Miles EW
    J Biol Chem; 1991 Apr; 266(12):7618-25. PubMed ID: 1673461
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evidence that mutations in a loop region of the alpha-subunit inhibit the transition from an open to a closed conformation in the tryptophan synthase bienzyme complex.
    Brzović PS; Sawa Y; Hyde CC; Miles EW; Dunn MF
    J Biol Chem; 1992 Jun; 267(18):13028-38. PubMed ID: 1618800
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The tryptophan synthase alpha 2 beta 2 complex. Cleavage of a flexible loop in the alpha subunit alters allosteric properties.
    Miles EW
    J Biol Chem; 1991 Jun; 266(17):10715-8. PubMed ID: 1904055
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Origin of the mutual activation of the alpha and beta 2 subunits in the alpha 2 beta 2 complex of tryptophan synthase. Effect of alanine or glycine substitutions at proline residues in the alpha subunit.
    Ogasahara K; Hiraga K; Ito W; Miles EW; Yutani K
    J Biol Chem; 1992 Mar; 267(8):5222-8. PubMed ID: 1544905
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lysine 87 in the beta subunit of tryptophan synthase that forms an internal aldimine with pyridoxal phosphate serves critical roles in transimination, catalysis, and product release.
    Lu Z; Nagata S; McPhie P; Miles EW
    J Biol Chem; 1993 Apr; 268(12):8727-34. PubMed ID: 8473317
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Site-specific mutagenesis of the alpha subunit of tryptophan synthase from Salmonella typhimurium. Changing arginine 179 to leucine alters the reciprocal transmission of substrate-induced conformational changes between the alpha and beta 2 subunits.
    Kawasaki H; Bauerle R; Zon G; Ahmed SA; Miles EW
    J Biol Chem; 1987 Aug; 262(22):10678-83. PubMed ID: 3112150
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity.
    Ferrari D; Yang LH; Miles EW; Dunn MF
    Biochemistry; 2001 Jun; 40(25):7421-32. PubMed ID: 11412095
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conformational changes and subunit communication in tryptophan synthase: effect of substrates and substrate analogs.
    Strambini GB; Cioni P; Peracchi A; Mozzarelli A
    Biochemistry; 1992 Aug; 31(33):7535-42. PubMed ID: 1510940
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The alpha subunit of tryptophan synthase. Evidence that aspartic acid 60 is a catalytic residue and that the double alteration of residues 175 and 211 in a second-site revertant restores the proper geometry of the substrate binding site.
    Nagata S; Hyde CC; Miles EW
    J Biol Chem; 1989 Apr; 264(11):6288-96. PubMed ID: 2649498
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Site-directed mutagenesis of the alpha subunit of tryptophan synthase from Salmonella typhimurium.
    Ahmed SA; Kawasaki H; Bauerle R; Morita H; Miles EW
    Biochem Biophys Res Commun; 1988 Mar; 151(2):672-8. PubMed ID: 3126743
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tryptophan synthase mutations that alter cofactor chemistry lead to mechanism-based inactivation.
    Jhee KH; McPhie P; Ro HS; Miles EW
    Biochemistry; 1998 Oct; 37(41):14591-604. PubMed ID: 9772188
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Thermal inactivation of tryptophan synthase. Stabilization by protein-protein interaction and protein-ligand interaction.
    Ruvinov SB; Miles EW
    J Biol Chem; 1994 Apr; 269(16):11703-6. PubMed ID: 8163467
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tryptophan synthase alpha subunit glutamic acid 49 is essential for activity. Studies with 19 mutants at position 49.
    Yutani K; Ogasahara K; Tsujita T; Kanemoto K; Matsumoto M; Tanaka S; Miyashita T; Matsushiro A; Sugino Y; Miles EW
    J Biol Chem; 1987 Oct; 262(28):13429-33. PubMed ID: 2888759
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.